ChemicalBook >> CAS DataBase List >>AEM1
AEM1
- CAS No.
- 1030123-90-0
- Chemical Name:
- AEM1
- Synonyms
- AEM1 >=98% (HPLC);AEM1, 10 mM in DMSO;AEM1 (NRF2 inhibitor AEM1);AEM-1,AEM1,inhibit,AEM 1,Inhibitor,Keap1-Nrf2;N-(1,3-Benzodioxol-5-ylmethyl)-5-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4-amine;Thieno[2,3-d]pyrimidin-4-amine, N-(1,3-benzodioxol-5-ylmethyl)-5-(4-fluorophenyl)-;N-(benzo[d][1,3]dioxol-5-ylmethyl)-5-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4-amine;N-[(2H-1,3-benzodioxol-5-yl)methyl]-5-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4-amine;1-(2H-1,3-benzodioxol-5-yl)-N-[5-(4-fluorophenyl)-1H,4H-thieno[2,3-d]pyrimidin-4-ylidene]methanamine
- CBNumber:
- CB23152537
- Molecular Formula:
- C20H14FN3O2S
- Molecular Weight:
- 379.41
- MDL Number:
- MFCD15017488
- MOL File:
- 1030123-90-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
Last updated:2026-07-27 17:00:41
| Product description | Number | Pack Size | Price |
| AEM1 ≥98% (HPLC) | SML1556 | 5mg | $101 |
| AEM1 ≥98% (HPLC) | SML1556 | 25mg | $408 |
| AEM1 ≥98% | 18321 | 1mg | $36 |
| AEM1 ≥98% | 18321 | 5mg | $110 |
| AEM1 ≥98% | 18321 | 10mg | $203 |
| Boiling point | 582.1±50.0 °C(Predicted) |
|---|---|
| Density | 1.457±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMF: 30 mg/mL; DMF:PBS (pH 7.2) (1:4): 0.2 mg/mL; DMSO: 20 mg/mL; Ethanol: 0.25 mg/mL |
| form | A crystalline solid |
| pka | 5.04±0.40(Predicted) |
| color | White to off-white |
| InChI | 1S/C20H14FN3O2S/c21-14-4-2-13(3-5-14)15-9-27-20-18(15)19(23-10-24-20)22-8-12-1-6-16-17(7-12)26-11-25-16/h1-7,9-10H,8,11H2,(H,22,23,24) |
| InChIKey | QGYLTGSHWIGJJD-UHFFFAOYSA-N |
| SMILES | Fc1ccc(cc1)c2c3c([s]c2)[nH]cn[c]3=NCc4cc5c(cc4)OCO5 |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
AEM1 price More Price(28)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML1556 | AEM1 ≥98% (HPLC) | 1030123-90-0 | 5mg | $101 | 2026-04-30 | Buy |
| Sigma-Aldrich | SML1556 | AEM1 ≥98% (HPLC) | 1030123-90-0 | 25mg | $408 | 2026-04-30 | Buy |
| Cayman Chemical | 18321 | AEM1 ≥98% | 1030123-90-0 | 1mg | $36 | 2026-04-30 | Buy |
| Cayman Chemical | 18321 | AEM1 ≥98% | 1030123-90-0 | 5mg | $110 | 2026-04-30 | Buy |
| Cayman Chemical | 18321 | AEM1 ≥98% | 1030123-90-0 | 10mg | $203 | 2026-04-30 | Buy |
AEM1 Chemical Properties,Uses,Production
Uses
N-(1,3-Benzodioxol-5-ylmethyl)-5-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4-amine Inhibits deregulated NRF2 transcriptional activity in cancer.
Biological Activity
AEM1 (ARE expression modulator 1) is also a selective inhibitor of sirtuin 2, which is a protein deacetylase mediated by NAD+. Sirtuin 2 supports tumor cell proliferation, thus its inhibition stimulates cell death in tumors.', 'AEM1 is a potent inhibitor of deregulated Nrf2 transcriptional activity. AEM1 broadly decreases the expression of NRF2 controlled genes and sensitizes A549 cells to various chemotherapeutic agents.
AEM1 Preparation Products And Raw materials
Raw materials
Preparation Products
AEM1 Suppliers
Global( 51)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +86-13203830695 | laboratory@coreychem.com | China | 30203 | 58 |
| BOC Sciences | 16314854226; +8616314854226 | inquiry@bocsci.com | United States | 19852 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 38999 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 54746 | 58 | |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4853 | 55 | |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| ShangHai Biochempartner Co.,Ltd | 177-54423994 17754423994 | 2853530910@QQ.com | China | 8000 | 62 |
| Henan Alfachem Co.,Ltd. | 0371-55051623 18137891487 | 3983243027@qq.com | China | 9957 | 58 |
1030123-90-0(AEM1)Related Search:
N-(benzo[d][1,3]dioxol-5-ylmethyl)-5-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4-amine
N-(1,3-Benzodioxol-5-ylmethyl)-5-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4-amine
AEM1
(NRF2 inhibitor AEM1)
Thieno[2,3-d]pyrimidin-4-amine, N-(1,3-benzodioxol-5-ylmethyl)-5-(4-fluorophenyl)-
AEM1 >=98% (HPLC)
AEM-1,AEM1,inhibit,AEM 1,Inhibitor,Keap1-Nrf2
1-(2H-1,3-benzodioxol-5-yl)-N-[5-(4-fluorophenyl)-1H,4H-thieno[2,3-d]pyrimidin-4-ylidene]methanamine
N-[(2H-1,3-benzodioxol-5-yl)methyl]-5-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4-amine
AEM1, 10 mM in DMSO
1030123-90-0
