TCS-3035
- CAS No.
- 871085-49-3
- Chemical Name:
- TCS-3035
- Synonyms
- TCS-3035;2-[4-[(Z)-(2,4-Dioxo-5-thiazolidinylidene)methyl]phenoxyacetic acid;(Z)-2-(4-((2,4-dioxothiazolidin-5-ylidene)methyl)phenoxy)acetic acid;Acetic acid, 2-[4-[(Z)-(2,4-dioxo-5-thiazolidinylidene)methyl]phenoxy]-
- CBNumber:
- CB23152991
- Molecular Formula:
- C12H9NO5S
- Molecular Weight:
- 279.27
- MDL Number:
- MFCD01835940
- MOL File:
- 871085-49-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
TCS-3035 price More Price(18)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 256879 | TCS 3035 Asreported | 871085-49-3 | 10mg | $460 | 2026-06-03 | Buy |
| Usbiological | 256879 | TCS 3035 Asreported | 871085-49-3 | 50mg | $1253 | 2026-06-03 | Buy |
| Biosynth | WJB08549 | TCS 3035 | 871085-49-3 | 25mg | $801.75 | 2026-06-05 | Buy |
| Biosynth | WJB08549 | TCS 3035 | 871085-49-3 | 50mg | $1283.5 | 2026-06-05 | Buy |
| Biosynth | WJB08549 | TCS 3035 | 871085-49-3 | 100mg | $1785 | 2026-06-05 | Buy |
TCS-3035 Chemical Properties, Uses, Production
Uses
TCS 3035 is a potent and selective GPR35 agonist.
Biological Activity
tcs3035, a gpr35 agonist, shows significantly high potency at rat and human gpr35 orthologs with pec50 values of 5.13 and 5.86, respectively [1]. g protein-coupled receptors (gpcrs) are the largest and most studied group of transmembrane polypeptides. gpr35 is a poorly characterized g protein-coupled receptor that plays an important role in immune-modulation, gastric function and the regulation of insulin secretion. gpr35 is predominantly expressed in the gastro-intestinal tract and immune tissues. the tryptophan metabolite kynurenic acid has been suggested to be the endogenous ligand for gpr35 [1].
in vitro
mutation to alanine of the conserved arginine at position 3.36 in either flag-hgpr35-eyfp or flag-rgpr35-eyfp resulted in a complete loss of agonist function of tcs3035 [1]. in addition, tcs3035-induced internalization of gpr35 is correlated with tcs3035 potency in receptor-β-arrestin-2 interaction bret assays. mutation to alanine of tyrosine 3.32 in transmembrane domain iii abolished β-arrestin-2 recruitment in response to tcs3035 [1].
target
gpr35
storage
Store at +4°C
References
1. jenkins l, alvarez-curto e, campbell k, de munnik s, canals m, schlyer s, et al. agonist activation of the g protein-coupled receptor gpr35 involves transmembrane domain iii and is transduced via galpha(1)(3) and beta-arrestin-2. br j pharmacol. 2011;162(3):733-48.
TCS-3035 Preparation Products And Raw materials
Raw materials
Preparation Products
TCS-3035 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 50068 | 58 |
| Supplier | Advantage |
|---|---|
| TargetMol Chemicals Inc. | 58 |
| TargetMol Chemicals Inc. | 58 |
| Aladdin Scientific | 58 |
