ChemicalBook >> CAS DataBase List >>4-(4-fluorophenyl)-N-(1H-indazol-5-yl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide

4-(4-fluorophenyl)-N-(1H-indazol-5-yl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide

4-(4-fluorophenyl)-N-(1H-indazol-5-yl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide structure

CAS No.: 817194-38-0

Chemical Name:: 4-(4-fluorophenyl)-N-(1H-indazol-5-yl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide

Synonyms: GSK180736A;CS-2541;GSK180736;GSK180736A (GSK180736);GSK180736A >=98% (HPLC);GRK2 inhibitor GS180736A;GSK-180736A (GSK 180736A;GSK180736A, 10 mM in DMSO;5-Pyrimidinecarboxamide, 4-(4-fluorophenyl)-1,2,3,4-tetrahydro-N-1H-indazol-5-yl-6-methyl-2-oxo-;4-(4-fluorophenyl)-N-(1H-indazol-5-yl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide

CBNumber:: CB23163890

Molecular Formula:: C19H16FN5O2

Molecular Weight:: 365.36

MDL Number:: MFCD30533616

MOL File:: 817194-38-0.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-07-14 16:49:18

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4-(4-fluorophenyl)-N-(1H-indazol-5-yl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide Properties

storage temp.	Store at -20°C
solubility	DMSO:57.67(Max Conc. mg/mL);157.83(Max Conc. mM) Ethanol:3.0(Max Conc. mg/mL);8.21(Max Conc. mM)
form	A crystalline solid
color	Light yellow to khaki
InChI	1S/C19H16FN5O2/c1-10-16(17(24-19(27)22-10)11-2-4-13(20)5-3-11)18(26)23-14-6-7-15-12(8-14)9-21-25-15/h2-9,17H,1H3,(H,21,25)(H,23,26)(H2,22,24,27)
InChIKey	HEAIGWIZTYAQTC-UHFFFAOYSA-N
SMILES	O=C(NC1=CC=C(NN=C2)C2=C1)C3=C(C)NC(NC3C4=CC=C(F)C=C4)=O
UNSPSC Code	12352200
NACRES	NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H315-H319-H335

Precautionary statements

P261-P305+P351+P338

WGK Germany

WGK 3

Storage Class

11 - Combustible Solids

NFPA 704

	0
2		0

4-(4-fluorophenyl)-N-(1H-indazol-5-yl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide price More Price(42)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	26182	GSK180736A ≥98%	817194-38-0	5mg	$103	2026-04-30	Buy
Cayman Chemical	26182	GSK180736A ≥98%	817194-38-0	10mg	$161	2026-04-30	Buy
Cayman Chemical	26182	GSK180736A ≥98%	817194-38-0	25mg	$378	2026-04-30	Buy
Cayman Chemical	26182	GSK180736A ≥98%	817194-38-0	50mg	$553	2026-04-30	Buy
Biosynth	SHB19438	GSK180736A	817194-38-0	50mg	$1117.5	2026-06-05	Buy

Product number	Packaging	Price	Buy
26182	5mg	$103	Buy
26182	10mg	$161	Buy
26182	25mg	$378	Buy
26182	50mg	$553	Buy
SHB19438	50mg	$1117.5	Buy

4-(4-fluorophenyl)-N-(1H-indazol-5-yl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide Chemical Properties, Uses, Production

Uses

GSK180736A is potent Rho-associated coiled-coil kinase 1 (ROCK1) inhibitor with an IC50 of 100 nM. GSK180736A is also a selective and ATP-competitive G protein-coupled receptor kinase 2 (GRK2) inhibitor with an IC50 of 0.77 μM.

Biological Activity

GSK180736A (GSK180736) is a Rho-related, coiled-coil protein kinase inhibitor that binds to GRK2 (G protein-coupled receptor kinase 2) with logIC50 of -6.6. The selectivity for GRK2 is more than 400-fold higher than that for GRK1 and GRK5.

in vitro

GSK180736A inhibits GRK2 with IC50 of 770 nM, 300-fold more potent than GRK5. It is a weak PKA inhibitor with IC50=30 μM; it is a potent ROCK1 inhibitor (IC50=100 nM).

target

IC 50

ROCK1: 100 nM (IC₅₀); GRK2: 770 nM (IC₅₀)

References

[1] Waldschmidt HV, et al. Structure-Based Design, Synthesis, and Biological Evaluation of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2 Inhibitors. J Med Chem. 2016 Apr 28;59(8):3793-807. DOI:10.1021/acs.jmedchem.5b02000

4-(4-fluorophenyl)-N-(1H-indazol-5-yl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide Preparation Products And Raw materials

Raw materials

Preparation Products

4-(4-fluorophenyl)-N-(1H-indazol-5-yl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide Suppliers

Global Suppliers ( 72)

Target	Value
ROCK (Cell-free assay)	100 nM
GRK2 (Cell-free assay)	6.6(pIC50)

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai Boyle Chemical Co., Ltd.		sales@boylechem.com	China	2915	55
Chembest Research Laboratories Limited	021-20908456	sales@BioChemBest.com	China	5996	61
BOC Sciences	1-631-485-4226; 16314854226	info@bocsci.com	United States	9920	65
MedChemexpress LLC	021-58955995	sales@medchemexpress.cn	United States	4853	58
Bide Pharmatech Ltd.	400-164-7117 18317119277	product02@bidepharm.com	China	40000	60
Mashilabs (Shanghai) Co.,Ltd.	19916721580	mafarm@126.com	China	4534	58
Shanghai JiYi Biotechnology Co. Ltd.	13621943973	sales@shjiyipharmatech.com	China	1166	55
Shanghai Lollane Biological Technology Co.,Ltd.	021-52996696，15000506266 15000506266		China	4859	55
Shanghaizehan biopharma technology co., Ltd.	021-61350663 13052117465	sales@zehanbiopharma.com	China	989	55
Shanghai YuanYe Biotechnology Co., Ltd.	15026964105	2881489226@qq.com	China	89667	60

Supplier	Advantage
Shanghai Boyle Chemical Co., Ltd.	55
Chembest Research Laboratories Limited	61
BOC Sciences	65
MedChemexpress LLC	58
Bide Pharmatech Ltd.	60
Mashilabs (Shanghai) Co.,Ltd.	58
Shanghai JiYi Biotechnology Co. Ltd.	55
Shanghai Lollane Biological Technology Co.,Ltd.	55
Shanghaizehan biopharma technology co., Ltd.	55
Shanghai YuanYe Biotechnology Co., Ltd.	60

View Latest Price from 4-(4-fluorophenyl)-N-(1H-indazol-5-yl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2026-07-14	GSK180736A 817194-38-0	$35.00-67.00		98.98%	10g	TargetMol Chemicals Inc.

GSK180736A
817194-38-0
$35.00-67.00
98.98%
TargetMol Chemicals Inc.

4-(4-fluorophenyl)-N-(1H-indazol-5-yl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide Spectrum

4-(4-fluorophenyl)-N-(1H-indazol-5-yl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide(817194-38-0)¹HNMR

817194-38-0 (4-(4-fluorophenyl)-N-(1H-indazol-5-yl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide) Related Search:

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GSK1940029 GSK 189254A GSK2110183 gsk2200150a 4-Methoxy-N-(2,4,6-triMethylphenyl)benzenesulfonaMide, 97%

1of2

4-(4-fluorophenyl)-N-(1H-indazol-5-yl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide GSK180736A CS-2541 GRK2 inhibitor GS180736A GSK180736 GSK180736A (GSK180736) 5-Pyrimidinecarboxamide, 4-(4-fluorophenyl)-1,2,3,4-tetrahydro-N-1H-indazol-5-yl-6-methyl-2-oxo- GSK180736A >=98% (HPLC) inhibit,ROCK,Inhibitor,ROK,Rho-kinase,Rho-associated kinase,Rho-associated protein kinase,GSK180736A,GSK-180736A GSK180736A, 10 mM in DMSO GSK-180736A (GSK 180736A 817194-38-0 API