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ChemicalBook >> CAS DataBase List >>4-(4-fluorophenyl)-N-(1H-indazol-5-yl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide

4-(4-fluorophenyl)-N-(1H-indazol-5-yl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide

4-(4-fluorophenyl)-N-(1H-indazol-5-yl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide Structure
4-(4-fluorophenyl)-N-(1H-indazol-5-yl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide structure
CAS No.
817194-38-0
Chemical Name:
4-(4-fluorophenyl)-N-(1H-indazol-5-yl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide
Synonyms
GSK180736A;CS-2541;GSK180736;GSK180736A (GSK180736);GSK180736A >=98% (HPLC);GRK2 inhibitor GS180736A;GSK180736A, 10 mM in DMSO;5-Pyrimidinecarboxamide, 4-(4-fluorophenyl)-1,2,3,4-tetrahydro-N-1H-indazol-5-yl-6-methyl-2-oxo-;4-(4-fluorophenyl)-N-(1H-indazol-5-yl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide;inhibit,ROCK,Inhibitor,ROK,Rho-kinase,Rho-associated kinase,Rho-associated protein kinase,GSK180736A,GSK-180736A
CBNumber:
CB23163890
Molecular Formula:
C19H16FN5O2
Molecular Weight:
365.36
MDL Number:
MFCD30533616
MOL File:
817194-38-0.mol
Last updated:2025-04-28 21:36:36
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4-(4-fluorophenyl)-N-(1H-indazol-5-yl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide Properties

storage temp. Store at -20°C
solubility DMSO:57.67(Max Conc. mg/mL);157.83(Max Conc. mM)
Ethanol:3.0(Max Conc. mg/mL);8.21(Max Conc. mM)
form A crystalline solid
color Light yellow to khaki
UNSPSC Code 12352200
NACRES NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
NFPA 704
0
2 0

4-(4-fluorophenyl)-N-(1H-indazol-5-yl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide price More Price(11)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 26182 GSK180736A 817194-38-0 5mg $93 2024-03-01 Buy
Cayman Chemical 26182 GSK180736A 817194-38-0 50mg $502 2024-03-01 Buy
Cayman Chemical 26182 GSK180736A 817194-38-0 10mg $146 2024-03-01 Buy
Cayman Chemical 26182 GSK180736A 817194-38-0 25mg $343 2024-03-01 Buy
ChemScene CS-6388 GSK180736A 97.03% 817194-38-0 50mg $400 2021-12-16 Buy
Product number Packaging Price Buy
26182 5mg $93 Buy
26182 50mg $502 Buy
26182 10mg $146 Buy
26182 25mg $343 Buy
CS-6388 50mg $400 Buy

4-(4-fluorophenyl)-N-(1H-indazol-5-yl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide Chemical Properties,Uses,Production

Uses

GSK180736A is potent Rho-associated coiled-coil kinase 1 (ROCK1) inhibitor with an IC50 of 100 nM. GSK180736A is also a selective and ATP-competitive G protein-coupled receptor kinase 2 (GRK2) inhibitor with an IC50 of 0.77 μM.

Biological Activity

GSK180736A (GSK180736) is a Rho-related, coiled-coil protein kinase inhibitor that binds to GRK2 (G protein-coupled receptor kinase 2) with logIC50 of -6.6. The selectivity for GRK2 is more than 400-fold higher than that for GRK1 and GRK5.

in vitro

GSK180736A inhibits GRK2 with IC50 of 770 nM, 300-fold more potent than GRK5. It is a weak PKA inhibitor with IC50=30 μM; it is a potent ROCK1 inhibitor (IC50=100 nM).

target

IC 50

ROCK1: 100 nM (IC50); GRK2: 770 nM (IC50)

References

[1] Waldschmidt HV, et al. Structure-Based Design, Synthesis, and Biological Evaluation of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2 Inhibitors. J Med Chem. 2016 Apr 28;59(8):3793-807. DOI:10.1021/acs.jmedchem.5b02000

4-(4-fluorophenyl)-N-(1H-indazol-5-yl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide Preparation Products And Raw materials

Raw materials

Preparation Products

4-(4-fluorophenyl)-N-(1H-indazol-5-yl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide Suppliers

Global( 58)Suppliers
TargetValue
ROCK
(Cell-free assay)		 100 nM
GRK2
(Cell-free assay)		 6.6(pIC50)
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32268 58
Career Henan Chemica Co 		+86-0371-86658258 +8613203830695 laboratory@coreychem.com China 30230 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
TargetMol Chemicals Inc. 		support@targetmol.com United States 38663 58
ShenZhen Trendseen Biological Technology Co.,Ltd. 		13417589054 trendseenbio@gmail.com China 11681 58
Aladdin Scientific 		tp@aladdinsci.com United States 57505 58
Shanghai Boyle Chemical Co., Ltd. sales@boylechem.com China 2922 55
Chembest Research Laboratories Limited +86-21-20908456 sales@BioChemBest.com China 6005 61
MedChemexpress LLC 021-58955995 sales@medchemexpress.cn United States 4861 58
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
TargetMol Chemicals Inc. 		58
Career Henan Chemica Co 		58
InvivoChem 		58
TargetMol Chemicals Inc. 		58
ShenZhen Trendseen Biological Technology Co.,Ltd. 		58
Aladdin Scientific 		58
Shanghai Boyle Chemical Co., Ltd. 55
Chembest Research Laboratories Limited 61
MedChemexpress LLC 58

View Lastest Price from 4-(4-fluorophenyl)-N-(1H-indazol-5-yl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
GSK180736A pictures 2025-04-27 GSK180736A
817194-38-0
 US $35.00-67.00 / mg 98.16% 10g TargetMol Chemicals Inc.
  • GSK180736A pictures
  • GSK180736A
    817194-38-0
  • US $35.00-67.00 / mg
  • 98.16%
  • TargetMol Chemicals Inc.

817194-38-0(4-(4-fluorophenyl)-N-(1H-indazol-5-yl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide)Related Search:

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GSK1940029 GSK 189254A GSK2110183 gsk2200150a 4-Methoxy-N-(2,4,6-triMethylphenyl)benzenesulfonaMide, 97%

1of2

4-(4-fluorophenyl)-N-(1H-indazol-5-yl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide GSK180736A CS-2541 GRK2 inhibitor GS180736A GSK180736 GSK180736A (GSK180736) 5-Pyrimidinecarboxamide, 4-(4-fluorophenyl)-1,2,3,4-tetrahydro-N-1H-indazol-5-yl-6-methyl-2-oxo- GSK180736A >=98% (HPLC) inhibit,ROCK,Inhibitor,ROK,Rho-kinase,Rho-associated kinase,Rho-associated protein kinase,GSK180736A,GSK-180736A GSK180736A, 10 mM in DMSO 817194-38-0 API