Danirixin
- CAS No.
- 954126-98-8
- Chemical Name:
- Danirixin
- Synonyms
- CS-1940;CS-2750;Danirixin;GSK1325756;Danirixin HCl;Danirixin (GSK1325756);Solabegron Hydrochloride;Danirixin, 10 mM in DMSO;Danirixin (GSK1325756) ，S6620;CXCR,GSK 1325756,Inhibitor,inhibit,Danirixin,CXC chemokine receptors,GSK-1325756
- CBNumber:
- CB73121091
- Molecular Formula:
- C19H21ClFN3O4S
- Molecular Weight:
- 441.9
- MDL Number:
- MFCD27987922
- MOL File:
- 954126-98-8.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| Danirixin ≥98% (HPLC) | SML3839 | 5 mg | $164 |
| Danirixin ≥98% (HPLC) | SML3839 | 25 mg | $660 |
| Danirixin ≥98% | 20980 | 1mg | $40 |
| Danirixin ≥98% | 20980 | 5mg | $177 |
| Danirixin ≥98% | 20980 | 10mg | $274 |
| More product size | |||
| Melting point | >153°C (dec.) |
|---|---|
| Boiling point | 533.1±50.0 °C(Predicted) |
| Density | 1.467±0.06 g/cm3(Predicted) |
| storage temp. | Refrigerator |
| solubility | Methanol (Slightly) |
| pka | 4.95±0.10(Predicted) |
| form | Solid |
| color | White to Light Brown |
| InChIKey | NGYNBSHYFOFVLS-LBPRGKRZSA-N |
| SMILES | O=C(NC1=CC=C(C(S([C@H]2CCCNC2)(=O)=O)=C1O)Cl)NC3=C(C(F)=CC=C3)C |
| FDA UNII | R318PGH5VP |
| UNSPSC Code | 12352200 |
| NACRES | NA.21 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302+H312+H332-H315-H319 | |||||||||
| Precautionary statements | P501-P261-P270-P271-P264-P280-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330-P302+P352+P312-P304+P340+P312 | |||||||||
| WGK Germany | WGK 3 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
Danirixin price More Price(20)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML3839 | Danirixin ≥98% (HPLC) | 954126-98-8 | 5 mg | $164 | 2026-03-19 | Buy |
| Sigma-Aldrich | SML3839 | Danirixin ≥98% (HPLC) | 954126-98-8 | 25 mg | $660 | 2026-03-19 | Buy |
| Cayman Chemical | 20980 | Danirixin ≥98% | 954126-98-8 | 1mg | $40 | 2024-03-01 | Buy |
| Cayman Chemical | 20980 | Danirixin ≥98% | 954126-98-8 | 5mg | $177 | 2024-03-01 | Buy |
| Cayman Chemical | 20980 | Danirixin ≥98% | 954126-98-8 | 10mg | $274 | 2024-03-01 | Buy |
Danirixin Chemical Properties,Uses,Production
Uses
Antidiabetic (β3 adrenoreceptor agonist).
Biological Activity
Danirixin (GSK1325756) is an orally active, selective CXC chemokine receptor 2 (CXCR2) antagonist with 78-fold lower affinity toward CXCR1 (CXCR2/CXCR1 IC50 = 12.5/977 nM by competitive binding against 0.225 nM [125I] CXCL8). Danirixin blocks agonist-induced neutrophil CD11b expression in vitro (IC50 = 420/890 nM against induction by 10 nM human CXCL1/r at CXCL2 using rat/human whole blood) and prevents lung neutrophils influx in rats in vivo following aerosol lipopolysaccharide or ozone challenge (ED50 = 1.4 and 16 mg/kg, respectively).
IC 50
CXCL8-CXCR2: 12.5 nM (IC50)
Danirixin Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 965 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29795 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32467 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471; | sales@sarms4muscle.com | China | 10473 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39040 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8615965530500 | nickzhang@hangyubiotech.com | China | 8614 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 |
