Danirixin
- CAS No.
- 954126-98-8
- Chemical Name:
- Danirixin
- Synonyms
- GSK1325756;CS-1940;CS-2750;Danirixin;Danirixin HCl;Danirixin (GSK1325756);Solabegron Hydrochloride;Danirixin, 10 mM in DMSO;Danirixin (GSK1325756) ，S6620;CXCR,GSK 1325756,Inhibitor,inhibit,Danirixin,CXC chemokine receptors,GSK-1325756
- CBNumber:
- CB73121091
- Molecular Formula:
- C19H21ClFN3O4S
- Molecular Weight:
- 441.91
- MDL Number:
- MFCD27987922
- MOL File:
- 954126-98-8.mol
- MSDS File:
- SDS
| Melting point | >153°C (dec.) |
|---|---|
| Boiling point | 533.1±50.0 °C(Predicted) |
| Density | 1.467±0.06 g/cm3(Predicted) |
| storage temp. | Refrigerator |
| solubility | Methanol (Slightly) |
| pka | 4.95±0.10(Predicted) |
| form | Solid |
| color | White to Light Brown |
| InChIKey | NGYNBSHYFOFVLS-LBPRGKRZSA-N |
| SMILES | O=C(NC1=CC=C(C(S([C@H]2CCCNC2)(=O)=O)=C1O)Cl)NC3=C(C(F)=CC=C3)C |
| FDA UNII | R318PGH5VP |
| UNSPSC Code | 12352200 |
| NACRES | NA.21 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302+H312+H332-H315-H319 | |||||||||
| Precautionary statements | P501-P261-P270-P271-P264-P280-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330-P302+P352+P312-P304+P340+P312 | |||||||||
| WGK Germany | WGK 3 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
Danirixin price More Price(43)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML3839 | Danirixin ≥98% (HPLC) | 954126-98-8 | 5 mg | $164 | 2026-04-30 | Buy |
| Sigma-Aldrich | SML3839 | Danirixin ≥98% (HPLC) | 954126-98-8 | 25 mg | $660 | 2026-04-30 | Buy |
| Cayman Chemical | 20980 | Danirixin ≥98% | 954126-98-8 | 1mg | $44 | 2026-04-30 | Buy |
| Cayman Chemical | 20980 | Danirixin ≥98% | 954126-98-8 | 5mg | $195 | 2026-04-30 | Buy |
| Cayman Chemical | 20980 | Danirixin ≥98% | 954126-98-8 | 10mg | $302 | 2026-04-30 | Buy |
Danirixin Chemical Properties, Uses, Production
Uses
Antidiabetic (β3 adrenoreceptor agonist).
Biological Activity
Danirixin (GSK1325756) is an orally active, selective CXC chemokine receptor 2 (CXCR2) antagonist with 78-fold lower affinity toward CXCR1 (CXCR2/CXCR1 IC50 = 12.5/977 nM by competitive binding against 0.225 nM [125I] CXCL8). Danirixin blocks agonist-induced neutrophil CD11b expression in vitro (IC50 = 420/890 nM against induction by 10 nM human CXCL1/r at CXCL2 using rat/human whole blood) and prevents lung neutrophils influx in rats in vivo following aerosol lipopolysaccharide or ozone challenge (ED50 = 1.4 and 16 mg/kg, respectively).
IC 50
CXCL8-CXCR2: 12.5 nM (IC50)
Danirixin Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2915 | 55 | |
| Shanghai Hope Chem Co., Ltd.， | +21-18501659228 18501659228 | info@hope-chem.com | China | 538 | 55 |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7545 | 61 |
| MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4853 | 58 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4859 | 55 | |
| Twochem Co.Ltd | 021-021-58111628 15800915896 | sales@twochem.com | China | 303 | 55 |
| ShangHai Angti Biotechnology Co., Ltd. | 13764913901 | info@angtibio.com | China | 4975 | 55 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Shanghai Changyan Chem & Tech Co., Ltd. | 021-20242659 18930833303 | sales@changyanchem.cn | China | 4998 | 55 |
| Qingdao IniKem BioPharmaTech Co.,Ltd | 0532-58268781 18561687109 | sales@inikem.com | China | 299 | 55 |
