JD-5037
- CAS No.
- 1392116-14-1
- Chemical Name:
- JD-5037
- Synonyms
- CS-2558;JD-5037;JD-5037 ，S6735;JD 5037;JD-5037;JD-5037, 10 mM in DMSO;Cannabinoid Receptor,inhibit,JD5037,JD-5037,Inhibitor;(S)-2-((((S)-3-(4-Chlorophenyl)-4-phenyl-4,5-dihydro-1H-pyrazol-1-yl)(4-chlorophenylsulfonamido)methylene)amino)-3-methylbutanamide;(S)-2-((Z)-(((S)-3-(4-chlorophenyl)-4-phenyl-4,5-dihydro-1H-pyrazol-1-yl)(4-chlorophenylsulfonamido)methylene)amino)-3-methylbutanamide;(S)-2-(((E)-((S)-3-(4-chlorophenyl)-4-phenyl-4,5-dihydro-1H-pyrazol-1-yl)((4-chlorophenyl)sulfonamido)methylene)amino)-3-methylbutanamide;Butanamide, 2-[[[(4S)-3-(4-chlorophenyl)-4,5-dihydro-4-phenyl-1H-pyrazol-1-yl][[(4-chlorophenyl)sulfonyl]amino]methylene]amino]-3-methyl-, (2S)-
- CBNumber:
- CB23167616
- Molecular Formula:
- C27H27Cl2N5O3S
- Molecular Weight:
- 572.51
- MDL Number:
- MFCD30533451
- MOL File:
- 1392116-14-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 721.6±70.0 °C(Predicted) |
|---|---|
| Density | 1.40±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | ≥143.2 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O |
| form | Solid |
| pka | 10.63±0.60(Predicted) |
| color | White to off-white |
| FDA UNII | ENZ75DG2Z6 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
JD-5037 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 12053 | JD5037 ≥95% | 1392116-14-1 | 1mg | $28 | 2026-04-30 | Buy |
| Cayman Chemical | 12053 | JD5037 ≥95% | 1392116-14-1 | 5mg | $104 | 2026-04-30 | Buy |
| Cayman Chemical | 12053 | JD5037 ≥95% | 1392116-14-1 | 10mg | $165 | 2026-04-30 | Buy |
| Cayman Chemical | 12053 | JD5037 ≥95% | 1392116-14-1 | 25mg | $275 | 2026-04-30 | Buy |
| Biosynth | FJ166461 | JD 5037 | 1392116-14-1 | 5mg | $250 | 2026-06-04 | Buy |
JD-5037 Chemical Properties,Uses,Production
Uses
JD 5037 is an anti-obesity drug candidate which acts as a peripherally-cannabinoid inverse agonist. Acts on the CB1 receptors.
Biological Activity
ki: 0.35 nmjd5037 is an inverse agonist at cb1 receptors.endocannabinoids, lipid mediators, can elicit a broad range of effects through g protein-coupled cb1 and cb2 receptors. activation of cb1r can promote food intake, increase lipogenesis in adipose tissue and liver, and cause insulin resistance and dyslipidemia, suggesting that the endocannabinoid/cb1r system is involved in obesity and metabolic complications.
in vitro
previous study showed that jd5037 had high cb1r binding affinity and >700-fold cb1/cb2 selectivity when compared with slv319. in addition, it was found that both slv319 and jd5037 were cb1r inverse agonists, verified by gtpgs binding. moreover, cb1r specificity of jd5037 was further confirmed as a potency ratio of >1,000 relative to a panel of 70 transporters, receptors, and ion channels [1].
in vivo
in mice with diet-induced obesity, the peripherally restricted jd5037 was found to be equieffective with its brain-penetrant parent compound in reducing appetite, body weight, hepatic steatosis, as well as insulin resistance, even though it did not occupy central cb1r or induce related behaviors. moreover, appetite and weight reduction caused by jd5037 were mediated by resensitizing diet-induced obesity mice to endogenous leptin via reversing the hyperleptinemia by decreasing leptin expression and secretion by adipocytes and increasing leptin clearance through the kidney [1].
IC 50
CB1: 1.5 nM (IC50)
References
[1] j. tam, r. cinar, j. liu, et al. peripheral cannabinoid-1 receptor inverse agonism reduces obesity by reversing leptin resistance. cell metabolism 16, 167-179 (2012).
JD-5037 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4861 | 55 | |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| parabiochem | 025-83453382-8005 | sale@parabiochem.com | China | 9577 | 55 |
| ShangHai Biochempartner Co.,Ltd | 177-54423994 17754423994 | 2853530910@QQ.com | China | 8000 | 62 |
| Shanghai Chaolan Chemical Technology Center | QQ：65489617 13301690235 | Sales@ATKchemical.com | China | 9699 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Medi-tech Bioscientific Co., Ltd. | 0519-83246372 13585352506 | China | 1838 | 58 | |
| Shanghai Biopharmaleader Co., Ltd. | +86 18721201413 | sales@biopharmaleader.com | China | 1711 | 58 |
| Twochem Co.Ltd. | 021-58111628 15800915896 | sales@twochem.com | China | 1782 | 58 |
