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Troxerutin

Troxerutin Structure
Troxerutin structure
CAS No.
7085-55-4
Chemical Name:
Troxerutin
Synonyms
Troxerutine;Venoruton;Troxerutin CRS;RUVEN;95%UV;Z-6000;95% UV;Qucrutin;Rufen P-4;VASTRIBIL
CBNumber:
CB2317568
Molecular Formula:
C33H42O19
Molecular Weight:
742.68
MDL Number:
MFCD00893813
MOL File:
7085-55-4.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-09-10 18:53:57
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Troxerutin Properties

Melting point 181°C
Boiling point 1058.4±65.0 °C(Predicted)
Density 1.65±0.1 g/cm3(Predicted)
storage temp. Sealed in dry,Store in freezer, under -20°C
solubility Freely soluble in water, slightly soluble in ethanol (96 per cent) and practically insoluble in methylene chloride.
form Solid
pka 5.92±0.40(Predicted)
color Light Yellow to Yellow
Merck 14,9789
BRN 4778232
Cosmetics Ingredients Functions SKIN CONDITIONING
InChIKey KMPBUGGPUQOWMJ-NXPSPVSKSA-N
SMILES O1[C@H]([C@@H]([C@@H]([C@H]([C@@H]1C)O)O)O)OC[C@H]2O[C@H]([C@@H]([C@H]([C@@H]2O)O)O)Oc3[c](c4c([o]c3c5cc(c(cc5)OCCO)OCCO)cc(cc4O)OCCO)=O
CAS DataBase Reference 7085-55-4(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII 7Y4N11PXO8
ATC code C05CA04,C05CA54
UNSPSC Code 12352200
NACRES NA.21

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P264-P270-P301+P312-P330-P501
Safety Statements  22-24/25
WGK Germany  3
RTECS  LK8331500
HS Code  2938100000
Storage Class 11 - Combustible Solids

Troxerutin price More Price(79)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich Y0000497 Troxerutin European Pharmacopoeia (EP) Reference Standard 7085-55-4 20 mg $241 2026-04-30 Buy
Sigma-Aldrich SML3724 Troxerutin ≥97% (HPLC) 7085-55-4 50 mg $87.1 2026-04-30 Buy
Sigma-Aldrich PHR2815 Troxerutin certified reference material, pharmaceutical secondary standard 7085-55-4 50MG $405 2026-04-30 Buy
Sigma-Aldrich Y0000497 Troxerutin European Pharmacopoeia (EP) Reference Standard 7085-55-4 y0000497 $220 2024-03-01 Buy
TCI Chemical T3541 Troxerutin >90.0%(HPLC) 7085-55-4 5g $59 2026-04-30 Buy
Product number Packaging Price Buy
Y0000497 20 mg $241 Buy
SML3724 50 mg $87.1 Buy
PHR2815 50MG $405 Buy
Y0000497 y0000497 $220 Buy
T3541 5g $59 Buy

Troxerutin Chemical Properties, Uses, Production

Preparation

Troxerutin can be prepared using starch as a filler and 95% ethanol as a wetting agent to form a suitable soft mass. After granulation and drying, the granules are sized using a nylon sieve. The mixture is then uniformly mixed with magnesium stearate and talc as lubricants before compression into tablets. The resulting tablets have a smooth and delicate appearance, good tablet hardness, stable tablet weight variation, and qualified content. This process improves the flowability and outflow rate of troxrutin powder, resulting in a fast and uniform granule flow rate, thus ensuring stable tablet weight variation. Granulation also reduces the amount of fine powder, minimizing contact between the powder and the punch, and preventing die pulling. This process requires no drying, consumes little energy, and is low-cost, making it suitable for industrial production.

Chemical Properties

Yellow Powder

Originator

Venoruton,Novartis Co

Uses

vasoprotectant

Uses

Troxerutin, a derivative of the naturally occurring bioflavonoid rutin, is thought to inhibit red cell and platelet aggregation, improve erythrocyte deformability, and improve plasma viscosity retinal microcirculation. A double-blind randomized clinical trial compared troxerutin with placebo in 27 patients with CRVO. The limitations of the study included a small number of patients and short follow-up time.

Uses

Used in the treatment of venous disorders

Manufacturing Process

In a nitrogen atmosphere 120 g of caustic soda (3 moles) in solution are added to 610 g of rutin (1 mol) suspended in 2 litres of water, the mixture being vigorously agitated by a mechanical stirrer, 241.5 g of ethylene chlorohydrin being then introduced at 55°C for 10 min. When all the chlorohydrin has been thus added the temperature is progressively raised to 75°C and maintained at this level for 2 hours. After cooling, in a nitrogen atmosphere, the pH value adjusted to 5 by the addition of dilute hydrochloric acid. The solution is kept in an ice box for 24 hours and then filtered to remove any impurities. At reduced pressure the solution is evaporated until dry, the residue taken up in 3 litres of boning methanol which dissolves the tri-(β-hydroxyethyl)rutin formed and leaves the sparingly soluble sodium chloride behind. The tri-(β-hydroxyethyl)rutin is recovered from its methanolic solution either by evaporation and refrigeration, or by evaporation precipitation with absolute ethanol. In either case tri-(β-hydroxyethyl)rutin obtained is in the form of small very hygroscopic crystals which contain alcohol of crystallization.These crystals are quickly shaken washed in a little cold absolute ethanol and then dried in vacuum at 100°C. 680 g of anhydrous tri-(β-hydroxyethyl)rutin are thus obtained in the form of a yellow powder which melts at 156°C.GB Patent No. 833,174; April 21, 1960; Assigned to Zyma S.A., a Swiss Corporation, of Route Etraz, Nyon Canton of Vaud, Switzerland

Therapeutic Function

Topical venotonic

Biological Activity

Troxerutin is a brain penetrant, vasoprotective flavonol isolated from Sophora japonica, which is present in many other plants including grains, fruits, and vegetables. Troxerutin exhibits multiple biological activities including anti-oxidative, anti-radiation, and anti-inflammatory. Recent study indicates th at troxerutin improves the synaptic failure induced by Aβ peptide. It appears th at Troxerutin could promote radioprotection by stimulating NEAT1 to upregulate PDPK1 expression by suppressing miR-147.

target

VEGFR | Wnt/β-catenin | NF-kB | SOD | PI3K | Akt

References

[1] Patent: CN104478972, 2017, B. Location in patent: Paragraph 0018; 0019; 0020; 0021; 0022; 0023; 0024-0031
[2] Patent: CN106892950, 2017, A. Location in patent: Paragraph 0018-0026
[3] Chinese Chemical Letters, 2013, vol. 24, # 3, p. 223 - 226
[4] Patent: CN103601772, 2016, B. Location in patent: Paragraph 0011-0014
[5] Patent: CN104447914, 2017, B. Location in patent: Paragraph 0013; 0014

Troxerutin Preparation Products And Raw materials

Raw materials

2-Chloroethanol Sodium hydroxide Rutin Ethylene oxide monoxerutin
Chitosan Methanol

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Preparation Products

Troxerutin Suppliers

Global Suppliers ( 523)
Supplier Tel Email Country ProdList Advantage
NANJING DORRA PHARMACEUTICAL TECHNOLOGY CO.,LTD. 025-82232968 15250951870 sales@dorrapharma.com China 21 58
Wuhan Beileye Biomedical Technology Co., Ltd. 18086118078 2696158611@qq.com China 4271 58
XI'AN RONGBAI BIOTECHNOLOGY CO., LTD. 029-81629930 18165286873 rb@xarbkj.com China 348 58
Sichuan Benepure Pharmaceutical Co., Ltd. 028-028-86798880 13308041363 online@benepure.com China 232 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
3B Pharmachem (Wuhan) International Co.,Ltd. 18930552037 3bsc@sina.com China 15813 69
Beijing Ouhe Technology Co., Ltd 13552068683 13522913783 2355560935@qq.com China 11777 60
JinYan Chemicals(ShangHai) Co.,Ltd. 13817811078 sales@jingyan-chemical.com China 9963 60
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
Chemsky（shanghai）International Co.,Ltd. 021-50135380 shchemsky@sina.com China 32273 50
Supplier Advantage
NANJING DORRA PHARMACEUTICAL TECHNOLOGY CO.,LTD. 58
Wuhan Beileye Biomedical Technology Co., Ltd. 58
XI'AN RONGBAI BIOTECHNOLOGY CO., LTD. 58
Sichuan Benepure Pharmaceutical Co., Ltd. 58
J & K SCIENTIFIC LTD. 76
3B Pharmachem (Wuhan) International Co.,Ltd. 69
Beijing Ouhe Technology Co., Ltd 60
JinYan Chemicals(ShangHai) Co.,Ltd. 60
Shanghai Hanhong Scientific Co.,Ltd. 64
Chemsky（shanghai）International Co.,Ltd. 50

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View Latest Price from Troxerutin manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Troxerutin pictures 2026-09-16 Troxerutin
7085-55-4
 1KG 99%min; EP 500KG WUHAN FORTUNA CHEMICAL CO., LTD
Troxerutin pictures 2026-09-11 Troxerutin
7085-55-4
 $10.00 1kg DAB1999,EP9 10000 Changsha Staherb Natural Ingredients Co., Ltd.
Troxerutin pictures 2026-09-10 Troxerutin
7085-55-4
 99% 2000 kg Chongqing Zhihe Biopharmaceutical Co., Ltd.
  • Troxerutin pictures
  • Troxerutin
    7085-55-4
  • 99%min; EP
  • WUHAN FORTUNA CHEMICAL CO., LTD
  • Troxerutin pictures
  • Troxerutin
    7085-55-4
  • $10.00
  • DAB1999,EP9
  • Changsha Staherb Natural Ingredients Co., Ltd.
  • Troxerutin pictures
  • Troxerutin
    7085-55-4
  • 99%
  • Chongqing Zhihe Biopharmaceutical Co., Ltd.

Troxerutin Spectrum

Troxerutin(7085-55-4)1HNMRTroxerutin(7085-55-4)IR1Troxerutin(7085-55-4)IR2

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3μ,4μ,7-Tris[O-(2-hydroxyethyl)]rutin, Troxerutin Troxerutin，Trihydroxyethylrutin 3',4',7-Tris(hydroxyethyl)rutin 3,5-Dihydroxy-3',4',7-tris(2-hydroxyethoxy)flavone 3-rutinoside Factor-P-zyma 2-[3,4-BIS(2-HYDROXYETHOXY)PHENYL]-3-[[6-O-(6-O-DEOXY-A-L-MANNOPYRANOSYL)-BETA-D-GLUCOPYRANOSYL]OXY]-5-HYDROXY-7-(2-HYDROXYETHOXY)-4H-1-BENZOPYRAN-4-ONE Trihydroxylrutin Trihydroxyethylrutoside Trioxyethylrutin 2-[3,4-Bis(2-hydroxethoxy)phenyl]-3-[[6-O-(6-O-deoxy-a-L-mannopyranosyl)-B-D-glucopyranosyl]oxy]-5-hydroxy-7-(2-hydroxyethoxy)-4H-1-benzopyran-4-one, Posorutin, Ruven, Vastribil, 4H-1-Benzopyran-4-one, 2-3,4-bis(2-hydroxyethoxy)phenyl-3-6-O-(6-deoxy-.alpha.-L-mannopyranosyl)-.beta.-D-glucopyranosyloxy-5-hydroxy-7-(2-hydroxyethoxy)- Venoruton VITAMIN P4 (TROXERUTIN) 7,3’,4’-tris[O-(2-hydroxyethyl)]rutin 2-[3,4-bis(2-hydroxyethoxy)phenyl]-5-hydroxy-7-(2-hydroxyethoxy)-3-[[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyl-2-oxanyl]oxymethyl]-2-oxanyl]oxy]-1-benzopyran-4-o Tris-O-(2-hydroxyethyl)rutin Trihydroxyethylrutin, CP Tris(hydroxyethyl)rutin Tris(hydroxyethyl)rutoside Rufen P-4 Venoruton P-4 Z-6000 TROXERUTIN(P) 2-[3,4-Bis(2-hydroxethoxy)phenyl]-3-[[6-O-(6-O-deoxy-α-L-Mannopyranosyl)-β-D-glucopyranosyl]oxy]-5-hydroxy-7-(2-hydroxyethoxy)-4H-1-benzopyran-4-one Trihydroxyethylrutin, 3',4',7-Tris[O-(2-hydroxyethyl)]rutin 4H-1-Benzopyran-4-one, 2-[3,4-bis(2-hydroxyethoxy)phenyl]-3-[[6-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-5-hydroxy-7-(2-hydroxyethoxy)- Hydroxyetbylrutin TROXERUTIN TRIHYDROXYETHYLRUTIN VASTRIBIL RUVEN POSORUTIN 3',4',7-TRIS-O-(2-HYDROXYETHYL)RUTIN Troxerutin CRS Troxerutin (85%) 2-(3,4-Bis(2-hydroxyethoxy)phenyl)-5-hydroxy-7-(2-hydroxyethoxy)-3-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-((((2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)methyl)tetrahydro-2H-pyran-2-yl)oxy)-4H-chromen-4-one Troxerutin USP/EP/BP Natural Sophora Japonica Extract 98% CAS?7085-55-4?Troxerutin Natural Herbal Extract Troxerutin (CAS 7085-55-4) Qucrutin TroxerutinQ: What is Troxerutin Q: What is the CAS Number of Troxerutin Q: What is the storage condition of Troxerutin Q: What are the applications of Troxerutin QuKe rutin Trihydroxyethylrutin Troxerutin-P OT15980 OT-15980 Troxrutin 95% UV 95%UV Qu Ke Lu Ding 4H-1-Benzopyran-4-one,2-[3,4-bis(2-hydroxyethoxy)phenyl]-3-[[6-O-(6-deoxy-a-L-mannopyranosyl)-b-D-glucopyranosyl]oxy]-5-hydroxy-7-(2-hydroxyethoxy)- Tris-O-(2-hydroxyethyl)rutin-RM Troxerutin(Oral/Injection) Troxerutin, 10 mM in DMSO Troxerutin (Standard) Troxerutine Trihydroxyethylrutin ≥90% Trihydroxyethylrutin 98.5% Trihydroxyethylrutin ≥98% Trihydroxyethylrutin ≥97% 7085-55-4