ST034307
- CAS No.
- 133406-29-8
- Chemical Name:
- ST034307
- Synonyms
- ST034307;ST034307 ，S0451;ST034307 >=98% (HPLC);ST034307, 10 mM in DMSO;ST034307;ST-034307;ST 034307;6-chloro-2-(trichloromethyl)-4H-chromen-4-one;6-Chloro-2-(trichloromethyl)-4H-1-benzopyran-4-one;4H-1-Benzopyran-4-one, 6-chloro-2-(trichloromethyl)-;Adenylate Cyclase,Inhibitor,ST 034307,inhibit,ST034307,ST-034307,Adenylyl cyclase
- CBNumber:
- CB23356179
- Molecular Formula:
- C10H4Cl4O2
- Molecular Weight:
- 297.95
- MDL Number:
- MFCD00760793
- MOL File:
- 133406-29-8.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| ST034307 ≥95% | 21777 | 1mg | $34 |
| ST034307 ≥95% | 21777 | 5mg | $150 |
| ST034307 ≥95% | 21777 | 10mg | $264 |
| ST034307 ≥95% | 21777 | 25mg | $576 |
| ST034307 ≥98%(HPLC) | 6271 | 50 | $590 |
| Boiling point | 329.1±42.0 °C(Predicted) |
|---|---|
| Density | 1.674±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Store in freezer, under -20°C |
| solubility | Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 6 mg/ml) |
| form | solid |
| color | Yellow |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. |
| InChI | 1S/C10H4Cl4O2/c11-5-1-2-8-6(3-5)7(15)4-9(16-8)10(12,13)14/h1-4H |
| InChIKey | NTDHYMSVCBGQJF-UHFFFAOYSA-N |
| SMILES | ClC(Cl)(Cl)C1=CC(C2=CC(Cl)=CC=C2O1)=O |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P280-P305+P351+P338 |
| WGK Germany | WGK 3 |
| Storage Class | 11 - Combustible Solids |
ST034307 price More Price(27)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 21777 | ST034307 ≥95% | 133406-29-8 | 1mg | $34 | 2024-03-01 | Buy |
| Cayman Chemical | 21777 | ST034307 ≥95% | 133406-29-8 | 5mg | $150 | 2024-03-01 | Buy |
| Cayman Chemical | 21777 | ST034307 ≥95% | 133406-29-8 | 10mg | $264 | 2024-03-01 | Buy |
| Cayman Chemical | 21777 | ST034307 ≥95% | 133406-29-8 | 25mg | $576 | 2024-03-01 | Buy |
| Tocris | 6271 | ST034307 ≥98%(HPLC) | 133406-29-8 | 50 | $590 | 2021-12-16 | Buy |
ST034307 Chemical Properties,Uses,Production
Description
ST-034307 (133406-29-8) is anovel selective adenylyl cyclase 1 (AC1) inhibitor, IC50=2.3 μM . Inhibits calcium2+-stimulated cAMP accumulation in HEK cells stably transfected with AC11. It was also shown to inhibit AC1 stimulated by forskolin- and Gαs-coupled receptors in HEK-AC1 cells. It enhanced μ-opioid receptor-mediated inhibition of AC1 but it blocked heterologous sensitization of AC1 caused by chronic μ-opioid receptor activation.1,3Displays analgesic properties in a mouse model of inflammatory pain.1A useful tool for exploring the involvement of AC1 in cellular signalling.2
Uses
ST 034307 is a useful intermediate.
in vivo
ST034307 (0.25 μg) causes a significant relief of CFA-induced inflammatory pain in mice. ST034307 exhibits an estimated median effective dose (E50) value for analgesia of 0.28 μg in the mouse pain model[1].
storage
Store at -20°C
References
[1] TARSIS F. BRUST. Identification of a selective small-molecule inhibitor of type 1 adenylyl cyclase activity with analgesic properties[J]. Science Signaling, 2017, 10 467. DOI:10.1126/scisignal.aah5381
[2] ZHENG JIANG. Cyclic-Nucleotide- and HCN-Channel-Mediated Phototransduction in Intrinsically Photosensitive Retinal Ganglion Cells.[J]. Journal of Chemical Theory and Computation, 2018: 652-664.e12. DOI:10.1016/j.cell.2018.08.055
[3] WATTS V J. Selective Adenylyl Cyclase Type 1 Inhibitors as Potential Opioid Alternatives For Chronic Pain[J]. Neuropsychopharmacology, 2017, 43 1: 215-216. DOI:10.1038/npp.2017.190
ST034307 Preparation Products And Raw materials
Raw materials
Preparation Products
ST034307 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32467 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6312 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4861 | 58 |
| Nanjing Dulai Biotechnology Co., Ltd. | 025-84699383-8003;025-846993838003-8003 18013301593;18013301590 | njduly@126.com | China | 3293 | 55 |
| Shanghai SunSyn Pharmaceutical Co., Ltd. | 021-18621020637 18621020637 | sales@sunsynpharma.com | China | 287 | 55 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9803 | 58 |
