TPA-023B
- CAS No.
- 425377-76-0
- Chemical Name:
- TPA-023B
- Synonyms
- TPA-023B;BAY-2873384;TPA 023B,TPA023B;2',6-difluoro-5'-(3-(2-hydroxypropan-2-yl)imidazo[1,2-b][1,2,4]triazin-7-yl)-[1,1'-biphenyl]-2-carbonitrile;[1,1'-Biphenyl]-2-carbonitrile, 2',6-difluoro-5'-[3-(1-hydroxy-1-methylethyl)imidazo[1,2-b][1,2,4]triazin-7-yl]-
- CBNumber:
- CB23400267
- Molecular Formula:
- C21H15F2N5O
- Molecular Weight:
- 391.37
- MDL Number:
- MFCD30532602
- MOL File:
- 425377-76-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| storage temp. | Store at -20°C |
|---|---|
| form | Solid |
| color | Light yellow to green yellow |
| FDA UNII | GMY695BP6Q |
TPA-023B price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | BT175710 | TPA023B | 425377-76-0 | 5mg | $1038.4 | 2026-06-04 | Buy |
| Biosynth | BT175710 | TPA023B | 425377-76-0 | 10mg | $1427.8 | 2026-06-04 | Buy |
| Biosynth | BT175710 | TPA023B | 425377-76-0 | 25mg | $2596 | 2026-06-04 | Buy |
| Biosynth | BT175710 | TPA023B | 425377-76-0 | 50mg | $3894 | 2026-06-04 | Buy |
| ChemScene | CS-0015602 | TPA-023B 98.45% | 425377-76-0 | 5mg | $433 | 2026-06-04 | Buy |
TPA-023B Chemical Properties, Uses, Production
Uses
TPA-023B is a high-affinity and orally active GABAA receptor α2/α3 subtype (Kis of 0.73 nM/2 nM) partial agonist and a α1 subtype (Ki of 1.8 nM) antagonist. TPA-023B has non-sedating anxiolytic-like properties[1].
in vivo
TPA-023B gives dose- and time-dependent occupancy of rat brain GABAA receptors as measured using an in vivo [3H]flumazenil binding assay, with 50% occupancy corresponding to a respective dose and plasma drug concentration of 0.09 mg/kg and 19 ng/mL[1].
TPA-023B is anxiolytic in rodent and primate (squirrel monkey) models of anxiety (elevated plus maze, fear-potentiated startle, conditioned suppression of drinking, conditioned emotional response) yet has no significant effects in rodent or primate assays of ataxia and/or myorelaxation (rotarod, chain-pulling, lever pressing), up to doses (10 mg/kg) corresponding to occupancy of greater than 99%[1].
References
[1] Atack JR, et al. Preclinical and clinical pharmacology of TPA023B, a GABAA receptor α2/α3 subtype-selective partial agonist. J Psychopharmacol. 2011 Mar;25(3):329-44. DOI:10.1177/0269881109354928
TPA-023B Preparation Products And Raw materials
Raw materials
Preparation Products
TPA-023B Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ChengDu TongChuangYuan Pharmaceutical Co.Ltd | 028-83379370 13880556291 | tcy@tcypharm.com | China | 8696 | 58 |
| Kaixin Chemical (Hong Kong) Limited | 010-88886666-01 13112345678 | loyson@qq.com | China | 589 | 55 |
| Jinan Kabotang Biological Technology Co.,Ltd. | 0531-61320525 15866703830 | figo.gao@foxmail.com | China | 7601 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Jiangsu Nanchuang Chemical and Life Health Research Institute Co., Ltd. | 15720605021 | zhang_lei@jsnchem.com | China | 1881 | 58 |
| Wuhan Yingnuo Pharmaceutical Technology Co., Ltd. | +86-027-59232304 15387063101 | 1276242629@qq.com | China | 9977 | 58 |
| Suzhou Sino Rare Chemical Co., Ltd. | 512-62857507 | sales@sinorarechem.com | China | 1864 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
| Xianning Shen Lan Biomedical Research and Development Co., Ltd. | 18171815831 | 1341138380@qq.com | China | 4573 | 58 |
| Nantong QuanYi Biotechnology Co., Ltd | 0513-66337626 18051384581 | sales@chemhifuture.com | China | 5985 | 58 |
