Sodium tolmetin dihydrate
- CAS No.
- 64490-92-2
- Chemical Name:
- Sodium tolmetin dihydrate
- Synonyms
- Tolmene;McN 2559-21-98;TOLMELINSODIUM;tolmetinsodiumdihydrate;sodiumtolmetindihydrate;Tolmetin Sodium (500 mg);Tolmetin Sodium (1670502);Tormetine Sodium (Dihydrate);TolMetin sodiuM salt dehydrate;TOLMETIN SODIUM SALT DIHYDRATE
- CBNumber:
- CB2352833
- Molecular Formula:
- C15H14NO3.Na.2H2O
- Molecular Weight:
- 315.3
- MDL Number:
- MFCD00150761
- MOL File:
- 64490-92-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 155-157 (dec.) |
|---|---|
| storage temp. | -20°C Freezer |
| solubility | Methanol (Slightly), Water (Slightly) |
| form | Solid |
| color | White to Beige |
| Water Solubility | Soluble in water |
| InChI | InChI=1S/C15H15NO3.Na.2H2O/c1-10-3-5-11(6-4-10)15(19)13-8-7-12(16(13)2)9-14(17)18;;;/h3-8H,9H2,1-2H3,(H,17,18);;2*1H2/q;+1;;/p-1 |
| InChIKey | QQILXENAYPUNEA-UHFFFAOYSA-M |
| SMILES | C1(=CC=C(CC([O-])=O)N1C)C(=O)C1C=CC(C)=CC=1.O.O.[Na+] |
| CAS DataBase Reference | 64490-92-2(CAS DataBase Reference) |
| FDA UNII | 02N1TZF99F |
| UNSPSC Code | 41116107 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H361d | |||||||||
| Precautionary statements | P202-P264-P270-P280-P301+P312-P308+P313 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22-38 | |||||||||
| Safety Statements | 36 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | UX9280000 | |||||||||
| HS Code | 2933995500 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral Repr. 2 |
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| NFPA 704 |
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Sodium tolmetin dihydrate price More Price(40)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 1670502 | Tolmetin sodium United States Pharmacopeia (USP) Reference Standard | 64490-92-2 | 500mg | $333 | 2026-04-30 | Buy |
| Cayman Chemical | 18195 | Tolmetin (sodium salt hydrate) ≥98% | 64490-92-2 | 1g | $36 | 2026-04-30 | Buy |
| Cayman Chemical | 18195 | Tolmetin (sodium salt hydrate) ≥98% | 64490-92-2 | 5g | $128 | 2026-04-30 | Buy |
| Cayman Chemical | 18195 | Tolmetin (sodium salt hydrate) ≥98% | 64490-92-2 | 10g | $236 | 2026-04-30 | Buy |
| Cayman Chemical | 18195 | Tolmetin (sodium salt hydrate) ≥98% | 64490-92-2 | 25g | $462 | 2026-04-30 | Buy |
Sodium tolmetin dihydrate Chemical Properties, Uses, Production
Chemical Properties
Crystalline Solid
Uses
beta-adrenergic blocker
Uses
Anti-inflammatory.
Definition
ChEBI: An organic sodium salt that is the dihydrate form of tolmetin sodium. Used as a nonselective nonsteroidal anti-inflammatory drug.
Biological Activity
tolmetin is a non-steroidal anti-inflammatory drug that non-selectively inhibits human cox-1 and -2 [1].the cyclooxygenase (cox) is a therapeutic target for preventing cancer. two isoforms of cox have been identified: cox 1 and cox 2. cox 1 has been constitutively expressed in most tissues and involved in mediating production of prostaglandins that control normal physiological functions, such as maintenance of the gastric mucosa and regulation of renal blood flow. cox 2 is undetectable in most normal tissues [2].
in vitro
tolmetin inhibited the activity of human cox-1 and -2 with ic50 values of 0.35 and 0.82 μm, respectively [1]. tolmetin was a competitive and reversible inhibitor of prostaglandin synthetase [3].
in vivo
in rats, pretreatment with tolmetin reduced prostaglandin synthesis by minces of renal medulla. incubation of medullary tissue with tolmetin decreased prostagland production. in anesthetized dogs, tolmetin reduced renal blood flow and shifted the distribution of renal cortical flow from the inner cortex toward the outer cortex [4].
References
[1] warner t d, giuliano f, vojnovic i, et al. nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: a full in vitro analysis[j]. proceedings of the national academy of sciences, 1999, 96(13): 7563-7568.
[2] dannenberg a j, altorki n k, boyle j o, et al. cyclo-oxygenase 2: a pharmacological target for the prevention of cancer[j]. the lancet oncology, 2001, 2(9): 544-551.
[3] taylor r j, salata j j. inhibition of prostaglandin synthetase by tolmetin (tolectin, mcn-2559), a new non-steroidal anti-inflammatory agent[j]. biochemical pharmacology, 1976, 25(22): 2479-2484.
[4] noordewier b, stygles v g, hook j b, et al. effect of tolmetin on renal function and prostaglandin metabolism[j]. journal of pharmacology and experimental therapeutics, 1978, 204(2): 461-468.
Sodium tolmetin dihydrate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Zhangjiagang huamao Fine chemical Co.,Ltd. | 0512-58327208; 13962221965;18261880368 | sales@huamao-chem.com | China | 33 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| Tianjin heowns Biochemical Technology Co., Ltd. | 400 638 7771 | sales@heowns.com | China | 14412 | 57 |
| Sinopharm Chemical Reagent Co,Ltd. | 86-21-63210123 | sj_scrc@sinopharm.com | China | 9791 | 79 |
| Spectrum Chemical Manufacturing Corp. | 021-021-021-67601398-809-809-809 15221380277 | marketing_china@spectrumchemical.com | China | 9643 | 60 |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7545 | 61 |
| MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4853 | 58 |
View Latest Price from Sodium tolmetin dihydrate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-15 | Tolmetin sodium dihydrate
64490-92-2
|
$113.00 | 99.57% | 10g | TargetMol Chemicals Inc. | ||
 |
2026-03-20 | Sodium tolmetin dihydrate
64490-92-2
|
$10.00 | 1KG | 99% | 10 mt | Hebei Chuanghai Biotechnology Co., Ltd | |
 |
2025-04-15 | Sodium tolmetin dihydrate
64490-92-2
|
$10.00 | 1kg | 99% | 20ton | Hebei Zhuanglai Chemical Trading Co.,Ltd |
-
- Tolmetin sodium dihydrate
64490-92-2
- $113.00
- 99.57%
- TargetMol Chemicals Inc.
-
- Sodium tolmetin dihydrate
64490-92-2
- $10.00
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- Sodium tolmetin dihydrate
64490-92-2
- $10.00
- 99%
- Hebei Zhuanglai Chemical Trading Co.,Ltd
