Ethyl 2-fluoropropionate
- CAS No.
- 349-43-9
- Chemical Name:
- Ethyl 2-fluoropropionate
- Synonyms
- ethyl 2-fluoropropanoate;2-fluoro-ethyl propionate;Ethyl 2-fluoropropionate;2-Fluoro-ethyl propanoate;Ethyl2-Fluoropropionate>Ethyl 2-fluoropropionate 98%;2-FLUOROPROPIONIC ACID ETHYL ESTER;2-fluoropropanoic acid ethyl ester;Propanoic acid, 2-fluoro-, ethyl ester;Ethyl 2-fluoropropionate ISO 9001：2015 REACH
- CBNumber:
- CB2372864
- Molecular Formula:
- C5H9FO2
- Molecular Weight:
- 120.12
- MDL Number:
- MFCD01320801
- MOL File:
- 349-43-9.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 125°C |
|---|---|
| Density | 0.997 |
| refractive index | 1.3750-1.3790 |
| Flash point | 29°C |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| form | clear liquid |
| color | Colorless to Light yellow to Light orange |
| InChI | InChI=1S/C5H9FO2/c1-3-8-5(7)4(2)6/h4H,3H2,1-2H3 |
| InChIKey | ODMITNOQNBVSQG-UHFFFAOYSA-N |
| SMILES | C(OCC)(=O)C(F)C |
| CAS DataBase Reference | 349-43-9(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS02,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H226-H315-H319 | |||||||||
| Precautionary statements | P210-P233-P240-P241+P242+P243-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P370+P378-P403+P235-P501 | |||||||||
| Hazard Codes | F | |||||||||
| Risk Statements | 10-36/38 | |||||||||
| Safety Statements | 16-36/37/39-3/9/49-26 | |||||||||
| RIDADR | 3272 | |||||||||
| HazardClass | FLAMMABLE | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29155090 | |||||||||
| Limited Quantities | 5.0 L (1.3 gallons) (liquid) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L) | |||||||||
| NFPA 704 |
|
Ethyl 2-fluoropropionate price More Price(37)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | E0663 | Ethyl 2-Fluoropropionate >97.0%(GC) | 349-43-9 | 5g | $39 | 2026-04-30 | Buy |
| TCI Chemical | E0663 | Ethyl 2-Fluoropropionate >97.0%(GC) | 349-43-9 | 25g | $108 | 2026-04-30 | Buy |
| TRC | TRC-E917965-5G | Ethyl 2-Fluoropropionate | 349-43-9 | 5g | $167 | 2026-06-03 | Buy |
| TRC | TRC-E917965-25G | Ethyl 2-Fluoropropionate | 349-43-9 | 25g | $223 | 2026-06-03 | Buy |
| TRC | TRC-E917965-100G | Ethyl 2-Fluoropropionate | 349-43-9 | 100g | $661 | 2026-06-03 | Buy |
Ethyl 2-fluoropropionate Chemical Properties, Uses, Production
Chemical Properties
Clear colorless to light yellow liquid
Uses
Ethyl 2-fluoropropionate is used as a solvent for lithium secondary batteries. Ethyl-2-fluoropropionate is also used as a reagent to synthesize a series of potent Nicotinic Acid (N429250) receptor agonists for the treatment of dyslipidemia, a health condition characterized by high triglyceride levels.
Synthesis Reference(s)
The Journal of Organic Chemistry, 55, p. 2311, 1990 DOI: 10.1021/jo00295a016
Synthesis
535-13-7
349-43-9
In a 2L four-neck flask equipped with a condenser, 1100 g of DMF, 273 g (2.0 mol) of ethyl 2-chloropropionate, 54 g of tetrabutylammonium bromide, 5.5 g of triethyl orthoformate and 255.2 g of potassium fluoride were added. The mixture was stirred and warmed to 100°C and reacted for 12 hours. After completion of the reaction, the mixture was purified by distillation to give 176.3 g of ethyl 2-fluoropropionate with 99.5% purity and 66.5% yield.
References
[1] Patent: CN105037150, 2017, B. Location in patent: Paragraph 0028; 0029
Ethyl 2-fluoropropionate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| SHANG FLUORO | 021-65170832 15601903708 | qinba_1@163.com | China | 401 | 60 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Ark Pharm, Inc. | 847-367-3680 | sales@arkpharminc.com | United States | 1669 | 56 |
| Beijing HwrkChemical Technology Co., Ltd | 89508211 18501085097 | sales.bj@hwrkchemical.com | China | 9407 | 55 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
| Jia Xing Isenchem Co.,Ltd | 0573-85285100 18627885956 | isenchem@163.com | China | 9389 | 66 |
View Latest Price from Ethyl 2-fluoropropionate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-04-04 | Ethyl 2-fluoropropionate
349-43-9
|
1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd.
|
||
 |
2019-07-06 | Ethyl 2-fluoropropionate
349-43-9
|
$1.00 | 1kg | 95%-99% | Career Henan Chemical Co |
-
- Ethyl 2-fluoropropionate
349-43-9
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- Ethyl 2-fluoropropionate
349-43-9
- $1.00
- 95%-99%
- Career Henan Chemical Co
