3-AMINO-1H-PYRAZOLO[3,4-B]QUINOXALINE
![3-AMINO-1H-PYRAZOLO[3,4-B]QUINOXALINE Structure](CAS/GIF/40254-90-8.gif)
- CAS No.
- 40254-90-8
- Chemical Name:
- 3-AMINO-1H-PYRAZOLO[3,4-B]QUINOXALINE
- Synonyms
- Brimonidine Impurity 8;NSC 693868;Cdk1/5 Inhibitor inhibitor;3-Aminopyrazolo[3,4-b]quinoxaline;1H-PYRAZOLO[3,4-B]QUINOXALIN-3-AMINE;3-AMINO-1H-PYRAZOLO[3,4-B]QUINOXALINE;1H-Pyrazolo[3,4-b]quinoxalin-3-ylamine;1H-Pyrazolo[3,4-b]quinoxalin-3-amine(9CI);Cdk1/5 Inhibitor - CAS 40254-90-8 - Calbiochem
- CBNumber:
- CB2381002
- Molecular Formula:
- C9H7N5
- Molecular Weight:
- 185.19
- MDL Number:
- MFCD04038461
- MOL File:
- 40254-90-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Cdk1/5 Inhibitor | 217720 | 5mg | $238 |
| Cdk1/5 Inhibitor ≥95% | 18740 | 1mg | $54 |
| Cdk1/5 Inhibitor ≥95% | 18740 | 5mg | $132 |
| Cdk1/5 Inhibitor ≥95% | 18740 | 10mg | $238 |
| NSC 693868 Asreported | 256063 | 10mg | $466 |
| Melting point | 292-293℃ (ethanol ) |
|---|---|
| Boiling point | 522.8±45.0 °C(Predicted) |
| Density | 1.570±0.06 g/cm3(Predicted) |
| storage temp. | Store at +4°C |
| solubility | Soluble to 100 mM in DMSO |
| form | Red solid |
| pka | 7.40±0.50(Predicted) |
| color | Orange to red |
| InChI | 1S/C9H7N5/c10-8-7-9(14-13-8)12-6-4-2-1-3-5(6)11-7/h1-4H,(H3,10,12,13,14) |
| InChIKey | DWHVZCLBMTZRQM-UHFFFAOYSA-N |
| UNSPSC Code | 12352200 |
3-AMINO-1H-PYRAZOLO[3,4-B]QUINOXALINE price More Price(22)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 217720 | Cdk1/5 Inhibitor | 40254-90-8 | 5mg | $238 | 2023-01-07 | Buy |
| Cayman Chemical | 18740 | Cdk1/5 Inhibitor ≥95% | 40254-90-8 | 1mg | $54 | 2026-04-30 | Buy |
| Cayman Chemical | 18740 | Cdk1/5 Inhibitor ≥95% | 40254-90-8 | 5mg | $132 | 2026-04-30 | Buy |
| Cayman Chemical | 18740 | Cdk1/5 Inhibitor ≥95% | 40254-90-8 | 10mg | $238 | 2026-04-30 | Buy |
| Usbiological | 256063 | NSC 693868 Asreported | 40254-90-8 | 10mg | $466 | 2026-06-03 | Buy |
3-AMINO-1H-PYRAZOLO[3,4-B]QUINOXALINE Chemical Properties,Uses,Production
Description
Cyclin-dependent kinases (Cdks) are key regulators of cell cycle progression and are therefore promising targets for cancer therapy. Cdk1/5 Inhibitor is a pyrazolo [3,4-b] quioxaline that inhibits Cdk1/cyclin B and Cdk5/p25 (IC50s = 600 and 400 nM, respectively). It less potently inhibits GSK3β (IC50 = 1 μM) and does not block Cdc25 activity. This compound is used to help define the roles of Cdk1 and Cdk5 in various signaling pathways.
Uses
Cyclin-dependent kinases (CDKs) are protein kinases and involved with the regulation of the cell cycle. NSC 693868 is an inhibitor of Cdk1/cyclin B and Cdk5/p25.Small molecules that target these protein kinases are valuable tools for investigating cellular signaling pathways and are potential therapeutic agents.
Definition
ChEBI: 2H-pyrazolo[4,3-b]quinoxalin-3-amine is a quinoxaline derivative.
Biological Activity
Inhibitor of cyclin-dependent kinases (cdks) and glycogen synthase kinase-3 (GSK-3). IC 50 values are 0.6, 0.4 and 1 μ M for cdk1/cyclin B, cdk5/p25 and GSK-3 respectively.
IC 50
Cdk1/cyclin B: 600 nM (IC50); Cdk5/p25: 400 nM (IC50); GSK-3β: 1 μM (IC50)
References
[1] MIGUEL A. ORTEGA . Pyrazolo[3,4-b]quinoxalines. A new class of cyclin-Dependent kinases inhibitors[J]. Bioorganic & Medicinal Chemistry, 2002, 10 7: Pages 2177-2184. DOI: 10.1016/s0968-0896(02)00069-x
[2] SHAOYONG CHEN. Androgen receptor phosphorylation and stabilization in prostate cancer by cyclin-dependent kinase 1.[J]. Proceedings of the National Academy of Sciences of the United States of America, 2006, 103 43: 15969-15974. DOI: 10.1073/pnas.0604193103
[3] TRI K NGUYEN Steven G. Dinaciclib (SCH727965) inhibits the unfolded protein response through a CDK1- and 5-dependent mechanism.[J]. Molecular Cancer Therapeutics, 2014: 662-674. DOI: 10.1158/1535-7163.mct-13-0714
[4] SUPACHAI TOPANURAK. High NaCl- and urea-induced posttranslational modifications that increase glycerophosphocholine by inhibiting GDPD5 phosphodiesterase.[J]. Proceedings of the National Academy of Sciences of the United States of America, 2013: 7482-7487. DOI: 10.1073/pnas.1305220110
3-AMINO-1H-PYRAZOLO[3,4-B]QUINOXALINE Preparation Products And Raw materials
3-AMINO-1H-PYRAZOLO[3,4-B]QUINOXALINE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49709 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52906 | 58 | |
| TargetMol Chemicals Inc. | 13564774135 | marketing@targetmol.com | United States | 19950 | 58 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15815 | 69 |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 9920 | 65 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8435 | 60 |
| Shanghai Chaolan Chemical Technology Center | QQ：65489617 13301690235 | Sales@ATKchemical.com | China | 9647 | 58 |
| Jinan blalong chemical co. LTD | 2710913286@qq.com | 1513643261@qq.com | China | 14227 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11123 | 58 |
View Lastest Price from 3-AMINO-1H-PYRAZOLO[3,4-B]QUINOXALINE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-27 | NSC 693868
40254-90-8
|
$1520.00-2500.00 | 10g | TargetMol Chemicals Inc. |
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- NSC 693868
40254-90-8
- $1520.00-2500.00
- TargetMol Chemicals Inc.
