HEMATIN
- CAS No.
- 15489-90-4
- Chemical Name:
- HEMATIN
- Synonyms
- heme;haem;HAEMATIN;HEMATIN;HEMATEIN;Hematins;phenodin;ferriheme;ferrihemate;Hematin BR
- CBNumber:
- CB2390068
- Molecular Formula:
- C34H31FeN4O5-
- Molecular Weight:
- 631.49
- MDL Number:
- MFCD00011615
- MOL File:
- 15489-90-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 180 °C |
|---|---|
| storage temp. | 2-8°C |
| solubility | DMF (Slightly), DMSO (Slightly, Heated, Sonicated), Pyridine (Slightly, Heated, |
| form | solid |
| color | Black |
| biological source | Porcine |
| Merck | 14,4635 |
| Stability | Light Sensitive |
| Cosmetics Ingredients Functions | HAIR CONDITIONING |
| InChIKey | BMUDPLZKKRQECS-HXFTUNQESA-K |
| SMILES | Cc1c(CCC(O)=O)c2cc3c(CCC(O)=O)c(C)c4cc5nc(cc6c(C=C)c(C)c(cc1n2)n6[Fe](O)n34)c(C)c5C=C |
| LogP | 7.193 (est) |
| CAS DataBase Reference | 15489-90-4 |
| NCI Dictionary of Cancer Terms | heme |
| FDA UNII | 0WP180G15G |
| UNSPSC Code | 12352202 |
| NACRES | NA.61 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P280-P261-P271 |
| PPE | Eyeshields, Gloves, type N95 (US) |
| WGK Germany | 3 |
| RTECS | NO6725000 |
| HS Code | 2934999090 |
| Storage Class | 11 - Combustible Solids |
| Toxicity | LD50 i.v. in rats: 4.32 mg/100 g (Lips) |
HEMATIN price More Price(29)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | H3281 | Hematin porcine | 15489-90-4 | 1g | $72.9 | 2026-04-30 | Buy |
| Sigma-Aldrich | H3281 | Hematin porcine | 15489-90-4 | 5g | $218 | 2026-04-30 | Buy |
| Usbiological | 238898 | Hematin 94+% ≥94%(HPLC) | 15489-90-4 | 1g | $340 | 2026-06-03 | Buy |
| TRC | TRC-H235303-500MG | Hematin | 15489-90-4 | 500mg | $327 | 2026-06-03 | Buy |
| TRC | TRC-H235303-250MG | Hematin | 15489-90-4 | 250mg | $206 | 2026-06-03 | Buy |
HEMATIN Chemical Properties,Uses,Production
Description
Produced from red blood cells, Hematin is a bluish-black or brownish pigment compound derived from hemoglobin by removal of the protein part and oxidation of the iron atom from ferrous Fe2+ to the ferric Fe3+ state, which does not combine with oxygen. It is effective to inhibit the synthesis of porphyrin and, at the same time, stimulate the synthesis of globin. It involves in the formation of cytochromes and peroxidases in the cell. Hematin is also a pharmaceutical used in the treatment of porphyria, which can be administered intravenously to halt the attack of acute porphyria. It functions in the liver to accelerate the production of heme and thus preventing the further accumulation of heme precursors, porphyrins, which is effective to alleviate the symptoms of porphyria.
References
https://en.wikipedia.org/wiki/Haematin
http://house.wikia.com/wiki/Hematin
https://en.oxforddictionaries.com/definition/us/hematin
http://medical-dictionary.thefreedictionary.com/hematin
Chemical Properties
Dark crystals with metalic luster
Uses
Indicator, biological stain.
Uses
Hematin was used in a study to test in vitro activities of the Rx-01 oxazolidinones against hospital and community pathogens. It was also used in a study to test in-vitro bacterial identification using fluorescence spectroscopy with an optical fiber system.
Definition
The hydroxide of heme. Not to be confused with hematein.
Biological Activity
Hematin is a hydroxide of heme. It may be used to tre at acute porphyric attacks. Hematin suppresses the hepatic aminolevulinic acid (ALA) function and replenishes cytochrome action by restoring the endogenous heme deficit. Early administration of hematin can prevent irreversible neuronal damage induced due to metabolic disorders.
Synthesis
Heme synthesis involves a seven-step enzymatic pathway, commencing with the condensation of glycine and succinyl-CoA to form δ-aminolevulinic acid (ALA). Subsequently, ALA is converted into porphyrinogen (PBG), which is further transformed into porphyrin IX. Ultimately, porphyrin IX binds with iron to form haem. The initial steps of this process occur within the mitochondria, whilst subsequent reactions take place in the cytoplasm. The specific steps are as follows:
(1) Condensation of Glycine and Succinyl-CoA (Enzyme: ALA synthase)
Reaction: Glycine + Succinyl-CoA → δ-aminolevulinic acid (ALA)
(2) Formation of Porphobilinogen (PBG) (Enzyme: ALA dehydratase)
Reaction: 2 ALA → PBG + 2 H2O
(3) Conversion of Porphobilinogen to Uroporphyrinogen III (Enzyme: Porphobilinogen deaminase)
Reaction: 4 PBG → Hydroxymethylbilane + 3 H2O
(4) Decarboxylation of Uroporphyrinogen III (Enzyme: Uroporphyrinogen decarboxylase)
Reaction: Hydroxymethylbilane → Uroporphyrinogen III + CO2 + H2O
(5) Oxidative Decarboxylation of Coproporphyrinogen III (Enzyme: Coproporphyrinogen oxidase)
Reaction: Coproporphyrinogen III → Protoporphyrinogen IX + CO2 + 2H2O
(6) Conversion of Protoporphyrinogen IX to Protoporphyrin IX (Enzyme: Protoporphyrinogen oxidase)
Reaction: Protoporphyrinogen IX → Protoporphyrin IX + H2O
(7) Insertion of Iron into Protoporphyrin IX (Enzyme: Ferrochelatase)
Reaction: Protoporphyrin IX + Fe2+ → Heme
Purification Methods
Crystallise it from pyridine. Dry it at 40o in vacuo.[Beilstein 26 III/IV 3047.]
HEMATIN Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Beijing HwrkChemical Technology Co., Ltd | 89508211 18501085097 | sales.bj@hwrkchemical.com | China | 9407 | 55 |
| Sichuan Kulinan Technology Co., Ltd | 400-1166-196 18981987031 | cdhxsj@163.com | China | 11674 | 57 |
| Hunan Hui Bai Shi Biotechnology Co., Ltd. | 0731-85526065 13308475853 | ivy@hnhbsj.com | China | 7236 | 62 |
| Spectrum Chemical Manufacturing Corp. | 021-021-021-67601398-809-809-809 15221380277 | marketing_china@spectrumchemical.com | China | 9643 | 60 |
| Dalian Meilun Biotech Co., Ltd. | 0411-62910999 13889544652 | sales@meilune.com | China | 4765 | 58 |
| ShangHai YuanYe Biotechnology Co., Ltd. | 15026964105 | shyysw007@163.com | China | 4998 | 60 |
| Chengdu Ai Keda Chemical Technology Co., Ltd. | 4008-755-333 18080918076 | 800078821@qq.com | China | 9706 | 55 |
| 9ding chemical ( Shanghai) Limited | 4009209199 | sales@9dingchem.com | China | 22497 | 55 |
View Lastest Price from HEMATIN manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-20 | HEMATIN
15489-90-4
|
$1.10 | 1g | 99.9% Min | 100 Tons | Dideu Industries Group Limited | |
 |
2026-06-30 | HEMATIN
15489-90-4
|
1kg | 98% | 1000 kg | BINBOBIO CO., LTD. | ||
 |
2026-05-11 | Hematin
15489-90-4
|
$42.00 | 99.25% | 10g | TargetMol Chemicals Inc. |
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