R-(+)-Etomoxir
- CAS No.
- 124083-20-1
- Chemical Name:
- R-(+)-Etomoxir
- Synonyms
- B80754;CS-1432;B 80754;B-80754;B807-54;B 807-54;B-807-54;S-(+)-ETOMOXIR;R-(+)-ETOMOXIR;R(+)-Etomoxir free acid
- CBNumber:
- CB2407236
- Molecular Formula:
- C17H23ClO4
- Molecular Weight:
- 326.82
- MDL Number:
- MFCD11227266
- MOL File:
- 124083-20-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 32-34°C |
|---|---|
| Boiling point | 405.0±25.0 °C(Predicted) |
| Density | 1.163 |
| storage temp. | Inert atmosphere,2-8°C |
| solubility | ≥32.7 mg/mL in DMSO; ≥109.6 mg/mL in EtOH; ≥48.3 mg/mL in H2O with gentle warming |
| form | Powder |
| color | Colorless to light yellow |
| InChI | InChI=1S/C17H23ClO4/c1-2-20-16(19)17(13-22-17)11-5-3-4-6-12-21-15-9-7-14(18)8-10-15/h7-10H,2-6,11-13H2,1H3/t17-/m1/s1 |
| InChIKey | DZLOHEOHWICNIL-QGZVFWFLSA-N |
| SMILES | O1C[C@]1(CCCCCCOC1=CC=C(Cl)C=C1)C(OCC)=O |
| FDA UNII | MSB3DD2XP6 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
R-(+)-Etomoxir price More Price(43)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 9004470 | (+)-Etomoxir ≥98% | 124083-20-1 | 5mg | $94 | 2026-04-30 | Buy |
| Cayman Chemical | 9004470 | (+)-Etomoxir ≥98% | 124083-20-1 | 10mg | $160 | 2026-04-30 | Buy |
| Cayman Chemical | 9004470 | (+)-Etomoxir ≥98% | 124083-20-1 | 25mg | $374 | 2026-04-30 | Buy |
| Cayman Chemical | 9004470 | (+)-Etomoxir ≥98% | 124083-20-1 | 50mg | $561 | 2026-04-30 | Buy |
| TRC | TRC-E933505-5MG | R-(+)-Etomoxir | 124083-20-1 | 5mg | $273 | 2026-06-03 | Buy |
R-(+)-Etomoxir Chemical Properties, Uses, Production
Description
Etomoxir, or 2[6(4-chlorophenoxy)hexyl]oxirane-2-carboxylate, is an irreversible inhibitor of carnitine palmitoyltransferase-1 (CPT-1) on the outer face of the inner mitochondrial membrane.This prevents the formation of acyl carnitines, a step that is necessary for the transport of fatty acyl chains from the cytosol into the intermembrane space of the mitochondria. This step is essential to the production of ATP from fatty acid oxidation. Etomoxir has also been identified as a direct agonist of PPARα. An off-target effect has been demonstrated at high concentrations of etomoxir on Coenzyme-A (CoA) metabolism.
Application
Etomoxir (R-(+)-Etomoxir) is an irreversible inhibitor of carnitine palmitoyltransferase 1a (CPT-1a), inhibits fatty acid oxidation (FAO) through CPT-1a and inhibits palmitate β-oxidation in human, rat and guinea pig.
Chemical Properties
Colourless Oil
Uses
R-(+)-Etomoxir is an inhibitor of carnitine palmitoyltransferase A (CPT1), which is required for the oexidation of long-chain acyl CoA esters. A strong inhibitor of mitochondrial CPT1 and is a candidate as an anti-diabetic drug
Definition
ChEBI: (2R)-2-[6-(4-chlorophenoxy)hexyl]-2-oxiranecarboxylic acid ethyl ester is an aromatic ether.
Biological Activity
etomoxir is a cell-permeable, irreversible, and stereospecific compound. etomoxir is shown to inhibit carnitine palmitoyltransferase (cpt)-1 and dgat activity in the mitochondria of rat heart h9c2 myoblastic cells at a concentration of 1-80 μm and 40 μm, respectively.
Mechanism of action
R-(+)-Etomoxir (ETO) is a carnitine palmitoyltransferase 1 (CPT1) inhibitor. ETO inhibits oxidative phosphorylation (OxPhos), a mitochondrial electron transport chain (ETC) that generates large amounts of ATP in cells. ETO prevents acylcarnitine formation. It is a step necessary for the translocation of fatty acyl chains from the cytoplasmic lysate to the mitochondrial intermembrane space. This step is essential for the production of ATP from fatty acid oxidation.
R-(+)-Etomoxir Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Changsha Fuzhen Biotechnology Co.，LTD | 15111215862 18229892877 | 3062105966@qq.com | China | 5569 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| Dalian Meilun Biotech Co., Ltd. | 0411-62910999 13889544652 | sales@meilune.com | China | 4765 | 58 |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7545 | 61 |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-6206333 13167063860 | anhua.mao@aladdin-e.com | China | 29977 | 65 |
| MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4853 | 58 |
| AdooQ BioScience, LLC | +1 (866) 930-6790 | info@adooq.com | United States | 2774 | 58 |
| ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 18149758185 | sales-cpd@caerulumpharma.com | China | 3493 | 58 |
Related articles
- Biological activity of Etomoxir
- Etomoxir ((R)-(+)-Etomoxir) is an irreversible inhibitor of carnitine palmitoyltransferase 1a (CPT-1a), inhibits fatty acid ox....
- Oct 29,2019
View Latest Price from R-(+)-Etomoxir manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-20 | Etomoxir
124083-20-1
|
$30.00-117.00 | 99.47% | 10g | TargetMol Chemicals Inc. | ||
 |
2021-07-13 | Etomoxir
124083-20-1
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd | ||
 |
2021-07-10 | Etomoxir
124083-20-1
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd |
