Gabapentin-lactam
- CAS No.
- 64744-50-9
- Chemical Name:
- Gabapentin-lactam
- Synonyms
- Gabapentin Related Compound A;3,3-PENTAMETHYLENE-4-BUTYROLACTAM;forgabapentine;Gabapentin RC A;Gabapentin-lactam;Gabapentin Lactum;Gabapentin USP RC A;Gabapentin EP Impurity A;Gabapentin impurity A CRS;3-AZASPIRO[4.5]DECAN-2-ONE
- CBNumber:
- CB2415644
- Molecular Formula:
- C9H15NO
- Molecular Weight:
- 153.22
- MDL Number:
- MFCD00177938
- MOL File:
- 64744-50-9.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| Gabapentin impurity A European Pharmacopoeia (EP) Reference Standard | Y0001281 | 20 mg | $164 |
| 4,4-Pentamethylene-2-pyrrolidinone 96% | 553743 | 25g | $133 |
| Gabapentin Related Compound A United States Pharmacopeia (USP) Reference Standard | 1287325 | 50mg | $1200 |
| 4,4-Pentamethylene-2-pyrrolidone >98.0%(GC) | P1695 | 5g | $39 |
| 4,4-Pentamethylene-2-pyrrolidone >98.0%(GC) | P1695 | 25g | $114 |
| More product size | |||
| Melting point | 84-89 °C(lit.) |
|---|---|
| Boiling point | 181 °C / 13mmHg |
| Density | 1.05±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | Soluble in DMSO (up to 40 mg/ml) |
| pka | 16.39±0.20(Predicted) |
| form | solid |
| color | White |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months. |
| InChI | 1S/C9H15NO/c11-8-6-9(7-10-8)4-2-1-3-5-9/h1-7H2,(H,10,11) |
| InChIKey | JAWPQJDOQPSNIQ-UHFFFAOYSA-N |
| SMILES | O=C1CC2(CCCCC2)CN1 |
| CAS DataBase Reference | 64744-50-9(CAS DataBase Reference) |
| FDA UNII | 0IP6953295 |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302+H312+H332-H315-H319 |
| Precautionary statements | P261-P280-P305+P351+P338 |
| PPE | Eyeshields, Gloves, type N95 (US) |
| Safety Statements | 22-24/25 |
| WGK Germany | 3 |
| RTECS | CM0120000 |
| HazardClass | IRRITANT |
| HS Code | 29337900 |
| Storage Class | 11 - Combustible Solids |
Gabapentin-lactam price More Price(28)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | Y0001281 | Gabapentin impurity A European Pharmacopoeia (EP) Reference Standard | 64744-50-9 | 20 mg | $164 | 2025-07-31 | Buy |
| Sigma-Aldrich | 553743 | 4,4-Pentamethylene-2-pyrrolidinone 96% | 64744-50-9 | 25g | $133 | 2025-07-31 | Buy |
| Sigma-Aldrich | 1287325 | Gabapentin Related Compound A United States Pharmacopeia (USP) Reference Standard | 64744-50-9 | 50mg | $1200 | 2025-07-31 | Buy |
| TCI Chemical | P1695 | 4,4-Pentamethylene-2-pyrrolidone >98.0%(GC) | 64744-50-9 | 5g | $39 | 2025-07-31 | Buy |
| TCI Chemical | P1695 | 4,4-Pentamethylene-2-pyrrolidone >98.0%(GC) | 64744-50-9 | 25g | $114 | 2025-07-31 | Buy |
Gabapentin-lactam Chemical Properties,Uses,Production
Description
Gabapentin lactam (CAS 64744-50-9) reduces protein aggregates and improves motor performance in a transgenic mouse model of Huntington’s disease.1 Displays neurotrophic effects, enhancing the formation of dendritic filopodia and inducing a network of F-actin-containing neurites in cultured hippocampal neurons.2 Promotes the survival of cultured central nervous system neurons possibly by opening mitochondrial KATP channels.3 Displays neuroprotective effects in a rat model of acute retinal ischemia.4
Chemical Properties
Gabapentin-lactam is White Solid
Uses
Gabapentin-lactam reduces protein aggregates and improves motor performance in a transgenic mouse model of Huntington’s disease. It opens mitochondrial ATP-dependent potassium channels.
Uses
Gabapentin Lactam reduces protein aggregates and improves motor performance in a transgenic mouse model of Huntington disease. It opens mitochondrial ATP-dependent potassium channels
Uses
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Definition
ChEBI: 2-Azaspiro[4.5]decan-3-one is an azaspiro compound.
General Description
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
References
[1] BIRGIT ZUCKER. Gabapentin-lactam, but not gabapentin, reduces protein aggregates and improves motor performance in a transgenic mouse model of Huntington’s disease.[J]. Naunyn-Schmiedeberg’s archives of pharmacology, 2004, 370 2: 131-139. DOI:10.1007/s00210-004-0959-9
[2] FRANK HENLE. Gabapentin-lactam induces dendritic filopodia and motility in cultured hippocampal neurons.[J]. Journal of Pharmacology and Experimental Therapeutics, 2006, 319 1: 181-191. DOI:10.1124/jpet.106.106146
[3] AMELIE PIELEN. Retinal ganglion cell survival is enhanced by gabapentin-lactam in vitro: evidence for involvement of mitochondrial KATP channels.[J]. Graefe’s Archive for Clinical and Experimental Ophthalmology, 2004, 242 3: 240-244. DOI:10.1007/s00417-004-0872-4
[4] W. LAGRÈZE T F R Müller Velten. The neuroprotective properties of gabapentin-lactam[J]. Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie. Albrecht von Graefe’s archive for clinical and experimental ophthalmology, 2001, 239 1: 845-849. DOI:10.1007/s00417-001-0383-5
Gabapentin-lactam Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29735 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21596 | 55 |
| Standardpharm Co. Ltd. | 86-714-3992388 | overseasales1@yongstandards.com | United States | 14332 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49977 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29795 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| SIMAGCHEM CORP | +86-5922680277 +86-13806087780 | sale@simagchem.com | China | 17346 | 58 |
| Hebei Zhanyao Biotechnology Co. Ltd | 15369953316 +8615369953316 | admin@zhanyaobio.com | China | 2123 | 58 |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | eric@witopchemical.com | China | 23541 | 58 |
| Chemsigma International Co., Ltd. | +86-2558742998 +86-19951791336 | info@chemsigma.com | China | 1801 | 58 |
View Lastest Price from Gabapentin-lactam manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2022-05-11 | Gabapentin-Lactam
64744-50-9
|
US $0.00 / g | 10g | 99.0% | 10tons | Wuhan Godbullraw Chemical Co.,ltd | |
 |
2022-04-29 | Gabapentin-Lactam
64744-50-9
|
US $0.00 / KG | 0.01KG | 99% | 1 tons | Wuhan Godbullraw Chemical Co.,ltd | |
 |
2021-11-18 | Gabapentin-lactam
64744-50-9
|
US $10.00 / Kg/Bag | 1Kg/Bag | 99% | 20 Tons | Hebei Zhanyao Biotechnology Co. Ltd |
-
- Gabapentin-Lactam
64744-50-9
- US $0.00 / g
- 99.0%
- Wuhan Godbullraw Chemical Co.,ltd
-
- Gabapentin-Lactam
64744-50-9
- US $0.00 / KG
- 99%
- Wuhan Godbullraw Chemical Co.,ltd
-
- Gabapentin-lactam
64744-50-9
- US $10.00 / Kg/Bag
- 99%
- Hebei Zhanyao Biotechnology Co. Ltd
