4,4-dimethyl-2-pyrrolidinone
- CAS No.
- 66899-02-3
- Chemical Name:
- 4,4-dimethyl-2-pyrrolidinone
- Synonyms
- 4,4-diMethylpyrrolidin-2-one;4,4-dimethylpyrrolidin;2-PYRROLIDONE,4,4-DIMETHYL;4,4-Dimethyl-2-pyrrolidone;4,4-dimethyl-2-pyrrolidinone;2-pyrrolidinone, 4,4-dimethyl-;4,4-Dimethyl-2-pyrrolidinone,95%
- CBNumber:
- CB51521886
- Molecular Formula:
- C6H11NO
- Molecular Weight:
- 113.16
- MDL Number:
- MFCD09864496
- MOL File:
- 66899-02-3.mol
- MSDS File:
- SDS
| Melting point | 38-40° |
|---|---|
| Boiling point | 150-155℃ (18 Torr) |
| Density | 0.945±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| pka | 16.70±0.40(Predicted) |
| form | Solid |
| color | White to cream |
| Water Solubility | Sparingly soluble in water.(0.26 g/L) (25°C), |
| Sensitive | Air Sensitive |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H301-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P301+P310a-P305+P351+P338-P405-P501a | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 2933998090 | |||||||||
| NFPA 704 |
|
4,4-dimethyl-2-pyrrolidinone price More Price(49)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | FD74951 | 4,4-Dimethyl-2-pyrrolidone | 66899-02-3 | 1g | $900 | 2026-06-04 | Buy |
| Biosynth | FD74951 | 4,4-Dimethyl-2-pyrrolidone | 66899-02-3 | 10g | $900 | 2026-06-04 | Buy |
| Biosynth | FD74951 | 4,4-Dimethyl-2-pyrrolidone | 66899-02-3 | 5g | $900 | 2026-06-04 | Buy |
| Biosynth | FD74951 | 4,4-Dimethyl-2-pyrrolidone | 66899-02-3 | 2g | $900 | 2026-06-04 | Buy |
| Biosynth | FD74951 | 4,4-Dimethyl-2-pyrrolidone | 66899-02-3 | 25g | $908.5 | 2026-06-04 | Buy |
4,4-dimethyl-2-pyrrolidinone Chemical Properties, Uses, Production
Uses
It is used as pharmaceutical intermediate. Benzoylthiophenes are allosteric enhancers (AE) of agonist activity at the A1 adenosine receptor.
Synthesis
130912-54-8
66899-02-3
The general procedure for the synthesis of 4,4-dimethyl-2-pyrrolidinone from ethyl 3,3-dimethyl-4-nitrobutanoate was as follows: ethyl 3,3-dimethyl-4-nitrobutanoate (22.65 g, 119.8 mmol) was dissolved in methanol (120 ml), followed by the addition of 10% palladium/activated carbon catalyst (250 mg). The reaction mixture was transferred to a hydrogenation unit (Parr Instrument Company), operated under evacuation and the reaction mixture was stirred at 110 °C. The reaction mixture was subjected to five hydrogenation operations with hydrogen (4.4 atmospheres) over a period of 16 hours. Upon completion of the reaction, the reaction mixture was filtered, the catalyst was washed with methanol, and the solvent was subsequently removed by evaporation to afford the oily product 4,4-dimethyl-2-pyrrolidinone (13.14 g, 97% yield).
References
[1] Patent: US2008/39456, 2008, A1. Location in patent: Page/Page column 44
4,4-dimethyl-2-pyrrolidinone Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Yangzhou Siyu Chemical Co.,Ltd. | 0514-87325867 | sales@siyuchem.com | China | 370 | 55 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Shanghai Jian Chao Chemical Technology Co., Ltd. | 150-2103-5486 18017383231 | 983544897@qq.com | China | 9335 | 55 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Shanghai Balmxy Pharmaceutical Co., Ltd | 021-24206007 13764915196 | sales@balmxy.com | China | 6959 | 55 |
| Shanghai Yongye Biotechnology Co., Ltd. | 86-021-61559134 15921386130 | 3423497944@qq.com | China | 8135 | 55 |
| Cool Pharm, Ltd | 021-60455363 18019463053 | sales@coolpharm.com | China | 8455 | 58 |
View Latest Price from 4,4-dimethyl-2-pyrrolidinone manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-12-26 | 4,4-dimethyl-2-pyrrolidinone
66899-02-3
|
$1.00 | 1KG | 99% | 1000KGS | Career Henan Chemical Co |
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- 4,4-dimethyl-2-pyrrolidinone
66899-02-3
- $1.00
- 99%
- Career Henan Chemical Co
