ALAMETHICIN
- CAS No.
- 59588-86-2
- Chemical Name:
- ALAMETHICIN
- Synonyms
- f-50;U-22324;ALMETHICIN;ALAMETHICIN;ALAMETHACIN;alamethicini;alamethicinf30;alamethicingamma;ANTIBIOTIC U-22324
- CBNumber:
- CB2423618
- Molecular Formula:
- C92H150N22O25
- Molecular Weight:
- 1964.31
- MDL Number:
- MFCD00151517
- MOL File:
- 59588-86-2.mol
- MSDS File:
- SDS
| Melting point | 267-270℃ |
|---|---|
| RTECS | AY1900000 |
| storage temp. | 2-8°C |
| solubility | Soluble in DMSO and ethanol. |
| form | Powder |
| FDA UNII | 0LT1I1B7S8 |
ALAMETHICIN price More Price(7)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | JCA58886 | Alamethicin | 59588-86-2 | 5mg | $1309.85 | 2026-06-04 | Buy |
| Biosynth | JCA58886 | Alamethicin | 59588-86-2 | 10mg | $1822.4 | 2026-06-04 | Buy |
| Biosynth | JCA58886 | Alamethicin | 59588-86-2 | 25mg | $3417 | 2026-06-04 | Buy |
| Biosynth | JCA58886 | Alamethicin | 59588-86-2 | 50mg | $5467 | 2026-06-04 | Buy |
| Usbiological | 001726 | Alamethicin | 59588-86-2 | 1mg | $262 | 2021-12-16 | Buy |
ALAMETHICIN Chemical Properties, Uses, Production
Uses
Alamethicin is used as a channel-forming ionophore that activates membrane enzymes, membrane channel-forming peptide. It is a 20-amino acid channel-forming peptide antibiotic that can function as a monovalent cation ionophore. Alamethicin has been used to develop methods for the routine assessment of potential new drug candidates to elicit their pharmacokinetic drug interactions.
Enzyme inhibitor
These voltage-dependent, channel-forming, peptaibol antibiotics (MWAlamethicin F-30 = 1964.40; CAS 27061-78-5) from the soil fungus Trichoderma viride NRRL 3199 are membrane-active oligopeptides isolated from that exhibit anti-bacterial and anti-fungal properties. Peptaibols are amphipathic, usually highly helical in structure, and typically form voltage dependent ion channels that uncouple oxidative phosphorylation, often attended by in bacterial and fungal cell death. Alamethicin F-30 has the sequence Ac-Aib-Pro-Aib-Ala-Aib-Ala-Gln-Aib- Val-Aib-Gly-Leu-Aib-Pro-Val-Aib-Aib-Glu-Gln-Phe-OH; Alamethicin F- 50 has the sequence Ac-Aib-Pro-Aib-Ala-Aib-Ala-Gln-Aib-Val-Aib-Gly- Leu-Aib-Pro-Val-Aib Aib-Gln-Gln-Phe-OH; and Alamethicin II has the sequence Ac-Aib-Pro-Aib-Ala-Aib-Aib-Gln-Aib-Val-Aib-Gly-Leu-Aib- Pro-Val-Aib-Aib-Glu-Gln-Phe-OH. Note: The name “peptaibol” is derived from the prefix “pep-“, the central syllable “aib”, and the suffix “-ol” to designate its peptide structure, the presence of an a-aminoisobutyryl unit, and the C-terminal alcohol.
ALAMETHICIN Preparation Products And Raw materials
Raw materials
Preparation Products
ALAMETHICIN Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Creative Peptides | info@creative-peptides.com | United States | 6083 | 56 | |
| Hunan chemfish Scientific co.,ltd | 85567275 18932438858 | sales06@chemfish.com | China | 5003 | 58 |
| BOC Sciences | 16314854226; +8616314854226 | inquiry@bocsci.com | United States | 19852 | 58 |
| Xibao Biotechnology (Shanghai) Co., Ltd. | 13761246140 | 58642714@qq.com | China | 415 | 58 |
| BOC Sciences | 16314854226 | inquiry@bocsci.com | United States | 9713 | 58 |
| SHANG HAI WEI LING BIOTECHNOLOGY CO.,LTD | 021-13917490980 13917490980 | 81939905@qq.com | China | 483 | 58 |
| Shaanxi Didu Pharmaceutical Co., Ltd. | 029-81124775 17791530730 | 1079@dideu.com | China | 10000 | 58 |
