5-(Chloromethyl)-8-quinolinol hydrochloride
- CAS No.
- 4053-45-6
- Chemical Name:
- 5-(Chloromethyl)-8-quinolinol hydrochloride
- Synonyms
- SKL220;Nsc83066;Aids125750;Aids-125750;TIMTEC-BB SBB000700;IFLAB-BB F2124-0006;5-(Chloromethyl)-8-quinolinol;8-quinolinol, 5-(chloromethyl)-;5-(CHLOROMETHYL)QUINOLIN-8-OL HYDROCHLORIDE;5-(Chloromethyl)-8-quinolinol hydrochloride
- CBNumber:
- CB2440976
- Molecular Formula:
- C10H9Cl2NO
- Molecular Weight:
- 230.09
- MDL Number:
- MFCD01790514
- MOL File:
- 4053-45-6.mol
| Melting point | 280 °C (decomp) |
|---|---|
| storage temp. | 2-8°C |
| EPA Substance Registry System | 8-Quinolinol, 5-(chloromethyl)-, hydrochloride (1:1) (4053-45-6) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501 |
| Hazard Codes | Xi,Xn |
| Risk Statements | 22 |
| TSCA | TSCA listed |
| HazardClass | IRRITANT |
| HS Code | 2933499090 |
5-(Chloromethyl)-8-quinolinol hydrochloride price More Price(23)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | OR2892 | 5-(Chloromethyl)-8-hydroxyquinoline hydrochloride 96% | 4053-45-6 | 1g | $123 | 2026-06-04 | Buy |
| aablocks | AA0076JQ | 5-(Chloromethyl)-8-quinolinol Hydrochloride >95% | 4053-45-6 | 100mg | $18 | 2026-05-28 | Buy |
| aablocks | AA0076JQ | 5-(Chloromethyl)-8-quinolinol Hydrochloride >95% | 4053-45-6 | 1g | $47 | 2026-05-28 | Buy |
| aablocks | AA0076JQ | 5-(Chloromethyl)-8-quinolinol Hydrochloride >95% | 4053-45-6 | 5g | $185 | 2026-05-28 | Buy |
| aablocks | AA0076JQ | 5-(Chloromethyl)-8-quinolinol Hydrochloride 96% | 4053-45-6 | 100g | $2809 | 2026-05-28 | Buy |
5-(Chloromethyl)-8-quinolinol hydrochloride Chemical Properties, Uses, Production
Synthesis
148-24-3
50-00-0
4053-45-6
14.6 g (0.1 mol) of 8-hydroxyquinoline, 16 mL of 32% aqueous hydrochloric acid and 16 mL (0.1 mol) of 37% aqueous formaldehyde were mixed at 0°C and passed through hydrogen chloride gas to react for 6 hours. After completion of the reaction, the mixture was allowed to stand at room temperature for 2 hours without stirring. The yellow solid produced by the reaction was collected by filtration, washed with 90% ethanol and dried under vacuum to afford 5-(chloromethyl)-8-quinolinol hydrochloride (19.0 g, 98% yield). The structure of the product was confirmed by 1H NMR (250 MHz, CDCl3): δ 5.32 (s, 2H), 7.53 (m, 1H), 7.85 (m, 2H), 8.12 (m, 1H), 9.12 (m, 1H), 9.28 (m, 1H).
References
[1] Journal of Medicinal Chemistry, 2014, vol. 57, # 24, p. 10455 - 10463
[2] Bioorganic and Medicinal Chemistry, 2005, vol. 13, # 3, p. 773 - 783
[3] Patent: WO2012/20389, 2012, A1. Location in patent: Page/Page column 22
[4] Journal of Medicinal Chemistry, 2015, vol. 58, # 21, p. 8616 - 8637
[5] Journal of Molecular Liquids, 2016, vol. 219, p. 396 - 404
5-(Chloromethyl)-8-quinolinol hydrochloride Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Beijing HwrkChemical Technology Co., Ltd | 89508211 18501085097 | sales.bj@hwrkchemical.com | China | 9407 | 55 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Chengdu Forest Science and Technology Development Co., Ltd. | 18030648795 18030648795 | sales@cdforestchem.com | China | 1998 | 58 |
| Finetech Industry Limited | 027-87465837 19945049750 | sales@finetechnology-ind.com | China | 9331 | 58 |
| Cool Pharm, Ltd | 021-60455363 18019463053 | sales@coolpharm.com | China | 8455 | 58 |
| Accela ChemBio Inc. | +1(858) 699-3322 | marketing@accelachem.com | United States | 6022 | 65 |
| Nanjing Chempioneer Pharmaceutical Co., Ltd. | 18068075658 | sales@chempioneer.com | China | 1803 | 58 |
| Zhengzhou Alfachem Co., Ltd. | 0371-53765687 18937137882 | 3969243885@qq.com | China | 7734 | 55 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
View Latest Price from 5-(Chloromethyl)-8-quinolinol hydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-02 | 5-(CHLOROMETHYL)-8-QUINOLINOL HYDROCHLORIDE
4053-45-6
|
$2.00-8.00 | 1KG | 99% | Henan Fengda Chemical Co., Ltd | ||
 |
2026-08-07 | 5-(Chloromethyl)-8-quinolinol
4053-45-6
|
$20.00-35.00 | 1KG | 99% | 200000KG | Shaanxi Dideu Medichem Co. Ltd | |
 |
2020-01-10 | 5-(CHLOROMETHYL)-8-QUINOLINOL HYDROCHLORIDE
4053-45-6
|
$1.00 | 1KG | 99% | 200kg | Career Henan Chemical Co |
-
- 5-(CHLOROMETHYL)-8-QUINOLINOL HYDROCHLORIDE
4053-45-6
- $2.00-8.00
- 99%
- Henan Fengda Chemical Co., Ltd
-
- 5-(Chloromethyl)-8-quinolinol
4053-45-6
- $20.00-35.00
- 99%
- Shaanxi Dideu Medichem Co. Ltd
-
- 5-(CHLOROMETHYL)-8-QUINOLINOL HYDROCHLORIDE
4053-45-6
- $1.00
- 99%
- Career Henan Chemical Co
