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2-(2-Methylpropyl)pyridine

2-(2-Methylpropyl)pyridine structure

CAS No.: 6304-24-1

Chemical Name:: 2-(2-Methylpropyl)pyridine

Synonyms: FEMA 3370;Pyridine, 2-(2-methylpropyl)-;FEMA NUMBER 3370;2-ISOBUTYLPYRIDINE;2-(2-METHYLPROPYL) PYRIDINE

CBNumber:: CB2454285

Molecular Formula:: C9H13N

Molecular Weight:: 135.21

MDL Number:: MFCD02262142

MOL File:: 6304-24-1.mol

MSDS File:: SDS

Last updated:2026-05-28 00:29:21

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2-(2-Methylpropyl)pyridine Properties

Boiling point	180-185 °C
Density	0.899
FLAVIS Number	14.058 \| 2-Isobutylpyridine
FEMA	3370 \| 2-(2-METHYLPROPYL)PYRIDINE
storage temp.	Inert atmosphere,Room Temperature
pka	5.83±0.19(Predicted)
Odor	at 0.10 % in dipropylene glycol. strong aromatic bell pepper
Odor Type	aromatic
JECFA Number	1311
LogP	2.60
Substances Added to Food (formerly EAFUS)	2-(2-METHYLPROPYL)PYRIDINE
CAS DataBase Reference	6304-24-1(CAS DataBase Reference)
FDA UNII	GS3K23H1Q8

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Danger

Hazard statements

H315-H319-H335

Precautionary statements

P261-P280a-P304+P340-P305+P351+P338-P405-P501a

Hazard Codes

Risk Statements

36/37/38-22

Safety Statements

26-36/37/39

NFPA 704

	2
2		0

2-(2-Methylpropyl)pyridine price More Price(12)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Matrix Scientific	205033	2-Isobutylpyridine	6304-24-1	25.00g	$375	2026-05-18	Buy
aablocks	AA003HEG	2-(2-methylpropyl)pyridine 95%	6304-24-1	1g	$52	2026-05-28	Buy
aablocks	AA003HEG	2-(2-methylpropyl)pyridine 95%	6304-24-1	5g	$146	2026-05-28	Buy
aablocks	AA003HEG	2-(2-methylpropyl)pyridine 95%	6304-24-1	25g	$518	2026-05-28	Buy
Crysdot	CD11084107	2-Isobutylpyridine 95+%	6304-24-1	25g	$398	2026-05-26	Buy

Product number	Packaging	Price	Buy
205033	25.00g	$375	Buy
AA003HEG	1g	$52	Buy
AA003HEG	5g	$146	Buy
AA003HEG	25g	$518	Buy
CD11084107	25g	$398	Buy

2-(2-Methylpropyl)pyridine Chemical Properties, Uses, Production

Description

May be prepared from 2-pycolyllithium and isopropyl bromide; from 2-methyl pyridine and isopropyl bromide in liquid ammonia in the presence of potassium metal and ferric nitrate.

Preparation

From β-picoline with NaNH2 and alkyl chloride or bromide.

Definition

ChEBI: 2-(2-Methylpropyl)pyridine is a member of pyridines.

Synthesis

100-71-0

823-96-1

622-39-9

6304-24-1

The methylation reaction was carried out by General Method 2 using 2-ethylpyridine and trimethylcyclotriboroxane as raw materials. Upon completion of the reaction, the products were purified by column chromatography to give two products: 21 (2-propylpyridine) as a colorless oil (19.1 mg, 79% yield) and 13a (2-isobutylpyridine) as a colorless oil (3.0 mg, 11% yield). The NMR data for 21 (2-propylpyridine) are as follows: 1H NMR (400 MHz, CDCl3) δ 8.53 (d, J = 4.8 Hz, 1H), 7.58 (td, J = 7.6, 1.6 Hz, 1H), 7.14 (d, J = 8.0 Hz, 1H), 7.11-7.08 (m, 1H), 2.77 (t, J = 7.6 Hz, 2H), 1.81-1.71 (m, 2H), 0.97 (t, J = 7.2 Hz, 3H). 13C NMR (100 MHz, CDCl3) δ 162.35, 149.26, 136.25, 122.83, 120.94, 40.49, 23.19, 13.94; HRMS (EI): calculated value C8H11N (M+) 121.0891, measured value 121.0893. The NMR data of 13a (2-isobutylpyridine) are as follows: 1H NMR (400 MHz, CDCl3) δ 8.53 (d, J = 4.4 Hz, 1H), 7.58 (td, J = 7.6, 1.6 Hz, 1H), 7.12-7.08 (m, 2H), 2.65 (d, J = 7.6 Hz, 2H), 2.15-2.05 (m, 1H), 0.93 (d, J = 6.8 Hz, 6H); 13C NMR (100 MHz). 13C NMR (100 MHz, CDCl3) δ 161.89, 149.50, 136.34, 123.81, 121.19, 47.93, 29.57, 22.74; HRMS (EI): calculated value C9H13N (M+) 135.1048, measured value 135.1046. Reaction conditions: in a 40 mL reaction tube, the substrate (0.2 mmol, 1 eq.), Pd(OAc)2 (4.5 mg, 0.02 mmol, 10 mol%), methyl cycloboroxane (55.7 μL, 0.4 mmol, 2 eq.), Cu(OAc)2 (72.8 mg, 0.4 mmol, 2 eq.) and benzoquinone (43.2 mg, 0.4 mmol, 2 eq.) were mixed together. 0.4 mmol, 2 eq.) were dissolved in 1 mL of acetic acid and reacted under oxygen atmosphere. The reaction tube was sealed with a PTFE-lined cap and the reaction mixture was stirred at 100 °C for 24 hours. After completion of the reaction, it was neutralized to pH=8-9 with 4N NaOH aqueous solution and then treated with 10 mL of saturated Na2S aqueous solution. The mixture was filtered through a diatomaceous earth pad and the diatomaceous earth was washed with 20 mL of dichloromethane. The filtrate was washed twice with saturated brine and the organic layer was dried with Na2SO4 and concentrated in vacuum. The residue was purified by silica gel column chromatography (eluent: hexane:ether=10:1) to give the methylated product.

References

[1] Journal of the American Chemical Society, 2006, vol. 128, # 39, p. 12634 - 12635
[2] Patent: WO2008/24953, 2008, A2. Location in patent: Page/Page column 6; 62; 67-68

2-(2-Methylpropyl)pyridine synthesis

Synthesis of 2-(2-Methylpropyl)pyridine from Pyridine

2-(2-Methylpropyl)pyridine Preparation Products And Raw materials

Raw materials

Pyridine, 2-chloro-6-(2-methylpropyl)- 6-Isobutylpyridin-2-ol 6-Isopropyl-2-oxo-1,2-dihydro-pyridine-3-carboxylic acid 2-n-Propylpyridine Isobutylmagnesium chloride

Trimethylboroxine 2-Iodopropane 2-Ethylpyridine 2-Chloropyridine 2-Picoline

2-Bromopropane Pyridine propene

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Preparation Products

2-(2-Methylpropyl)pyridine Suppliers

Global Suppliers ( 64)

Supplier	Tel	Email	Country	ProdList	Advantage
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
Alfa Aesar	400-6106006	saleschina@alfa-asia.com	China	30103	84
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
JinYan Chemicals(ShangHai) Co.,Ltd.	13817811078	sales@jingyan-chemical.com	China	9963	60
Shanghai Hanhong Scientific Co.,Ltd.	021-54306202 13764082696	info@hanhongsci.com	China	42917	64
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.	025-66113011 13913916777	cfzhang@aikonchem.com	China	19902	55
Shanghai Macklin Biochemical Co.,Ltd.	15221275939 15221275939	shenlinxing@macklin.cn	China	15775	55
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131885	58
Alfa Chemistry	+1-5166625404;	Info@alfa-chemistry.com	United States	20000	58
Dayang Chem (Hangzhou) Co.,Ltd.	+86-0571-88938639 17705817739	info@dycnchem.com	China	52451	58

Supplier	Advantage
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
Alfa Aesar	84
Energy Chemical	61
JinYan Chemicals(ShangHai) Co.,Ltd.	60
Shanghai Hanhong Scientific Co.,Ltd.	64
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.	55
Shanghai Macklin Biochemical Co.,Ltd.	55
Amadis Chemical Company Limited	58
Alfa Chemistry	58
Dayang Chem (Hangzhou) Co.,Ltd.	58

View Latest Price from 2-(2-Methylpropyl)pyridine manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2020-02-04	2-Isobutylpyridine 6304-24-1	$1.00	1KG	Min98% HPLC		Career Henan Chemical Co

2-Isobutylpyridine
6304-24-1
$1.00
Min98% HPLC
Career Henan Chemical Co

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FEMA NUMBER 3370 2-ISOBUTYLPYRIDINE 2-(2-METHYLPROPYL) PYRIDINE FEMA 3370 Pyridine, 2-(2-methylpropyl)- 6304-24-1 Organics