3-Nitro-4-chloro-4'-fluorobenzophenone
- CAS No.
- 31431-16-0
- Chemical Name:
- 3-Nitro-4-chloro-4'-fluorobenzophenone
- Synonyms
- (4-CHLORO-3-NITROPHENYL)(4-FLUOROPHENYL)METHANONE;Flubendazole Impurity 3;Benzophenone-4 Benzophenone-5;3-Nitro-4-Amino-4'-Fluorobenzophenone;3-Nitro-4-chloro-4'-fluorobenzophenone;4-CHLORO-3-NITRO-4'-FLUOROBENZOPHENONE;The condensate of ON-02 and hydrazine hydrate;4-Chloro-3-nitrophenyl(4-fluorophenyl) ketone;Methanone,(4-chloro-3-nitrophenyl) (4-fluorophenyl)-
- CBNumber:
- CB2457534
- Molecular Formula:
- C13H7ClFNO3
- Molecular Weight:
- 279.65
- MDL Number:
- MFCD03840494
- MOL File:
- 31431-16-0.mol
- MSDS File:
- SDS
| Boiling point | 419.2±45.0 °C(Predicted) |
|---|---|
| Density | 1.430±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| form | solid |
| color | Yellow |
| CAS DataBase Reference | 31431-16-0(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H319-H335-H302+H312+H332-H315 |
| Precautionary statements | P280-P305+P351+P338-P362+P364 |
| Hazard Codes | Xi |
| HS Code | 2914790090 |
3-Nitro-4-chloro-4'-fluorobenzophenone price More Price(60)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | PC1491 | 4-Chloro-4'-fluoro-3-nitrobenzophenone 97% | 31431-16-0 | 5g | $90 | 2026-06-04 | Buy |
| AK Scientific | L685 | 4-Chloro-3-nitro-4'-fluorobenzophenone 98% | 31431-16-0 | 1g | $25 | 2026-06-04 | Buy |
| AK Scientific | L685 | 4-Chloro-3-nitro-4'-fluorobenzophenone 98% | 31431-16-0 | 5g | $78 | 2026-06-04 | Buy |
| AK Scientific | L685 | 4-Chloro-3-nitro-4'-fluorobenzophenone 98% | 31431-16-0 | 10g | $133 | 2026-06-04 | Buy |
| AK Scientific | L685 | 4-Chloro-3-nitro-4'-fluorobenzophenone 98% | 31431-16-0 | 25g | $254 | 2026-06-04 | Buy |
3-Nitro-4-chloro-4'-fluorobenzophenone Chemical Properties, Uses, Production
Uses
(4-Chloro-3-nitrophenyl)(4-fluorophenyl)methanone (cas# 31431-16-0) is a useful chemical in the manufacturing process for flubendazole, an anthelmintic that is used in dogs and cats to treat parasites and worms.
Synthesis
462-06-6
38818-50-7
31431-16-0
To the reaction flask was added 1800 g of fluorobenzene and 2250 g of aluminum trichloride, and pre-cooled 3-nitro-4-chlorobenzoyl chloride solution was slowly added dropwise to the reaction flask, controlling the reaction temperature to be at 25-30 °C. After the dropwise addition was completed, the reaction was continued at this temperature for 2 hours. Upon completion of the reaction, the reaction mixture was slowly added dropwise to 10 kg of dilute hydrochloric acid at a concentration of 3.0%, ensuring that the temperature did not exceed 65 °C during this process. After stirring for 0.5 hours, the mixture was allowed to stand to allow the mixture to stratify, separating and retaining the lower organic phase. The organic phase was washed with 600 g of a 10% concentration aqueous sodium carbonate solution. Subsequently, the solvent o-dichlorobenzene was removed by distillation under reduced pressure, 5400 g of methanol was added to the residue and the mixture was heated to reflux. After stirring for 0.5 h, the mixture was cooled to promote crystallization. After filtration and drying, 2387 g of 4-chloro-3-nitro-4'-fluorodiphenyl ketone was obtained with a purity of 98.7% and an overall yield of 95.7%.
References
[1] Patent: CN107698516, 2018, A. Location in patent: Paragraph 0036
3-Nitro-4-chloro-4'-fluorobenzophenone Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| XiaoGan ShenYuan ChemPharm co,ltd | 15527621225; 15527621225 | 1791901229@qq.com | China | 6740 | 52 |
| Shanghai Fuhe Chemistry Technology Co., Ltd. | 0086-21-67651709 | cfx759@hotmail.com | China | 409 | 57 |
| Candia Thamtech Company Limited | 0371-86615086 18203638366 0371-86159066 13526786601 | China | 2011 | 60 | |
| Bellen Chemistry Co., Ltd. | 010-60400365-8001 15910885229 | service@bellenchem.com | China | 4514 | 60 |
| Henan CoreyChem Co., Ltd | 0371-86658258 | info@coreychem.com | China | 10442 | 58 |
| NanJing Xienuo bio Co.,Ltd. | 025-84112752 13805181430 | 154301870@qq.com | China | 999 | 55 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29626 | 60 |
View Latest Price from 3-Nitro-4-chloro-4'-fluorobenzophenone manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-07-21 | 3-NITRO-4-CHLORO-4'-FLUOROBENZOPHENONE
31431-16-0
|
$1.00 | 1Kg | 98% | 20T | Shaanxi Dideu Medichem Co. Ltd | |
 |
2019-07-06 | 3-NITRO-4-CHLORO-4'-FLUOROBENZOPHENONE
31431-16-0
|
$1.00 | 1KG | 98% | 100KG | Career Henan Chemical Co |
-
- 3-NITRO-4-CHLORO-4'-FLUOROBENZOPHENONE
31431-16-0
- $1.00
- 98%
- Shaanxi Dideu Medichem Co. Ltd
-
- 3-NITRO-4-CHLORO-4'-FLUOROBENZOPHENONE
31431-16-0
- $1.00
- 98%
- Career Henan Chemical Co
