CORT 118335
- CAS No.
- 1400902-13-7
- Chemical Name:
- CORT 118335
- Synonyms
- C118335);CORT 118335;Miricorilant;CORT 118335 (Miricorilant;2,4(1H,3H)-Pyrimidinedione, 6-(trans-4-phenylcyclohexyl)-5-[[3-(trifluoromethyl)phenyl]methyl]-
- CBNumber:
- CB24667782
- Molecular Formula:
- C24H23F3N2O2
- Molecular Weight:
- 428.45
- MDL Number:
- MOL File:
- 1400902-13-7.mol
| Density | 1.271±0.06 g/cm3(Predicted) |
|---|---|
| pka | 9.56±0.10(Predicted) |
| FDA UNII | 311Y5GV21M |
CORT 118335 Chemical Properties,Uses,Production
Uses
Miricorilant (CORT 118335) is a dual selective glucocorticoid (GR) modulator/mineralocorticoid (MR) antagonist. Miricorilant can be used for the research of hypothalamic-pituitary-adrenal (HPA) axis related disorders[1].
in vivo
CORT 118335 (3-30 mg/kg) potently suppresses endocrine responses to two different stressors (restraint and FST) in male rats[1].
| Animal Model: | Male Sprague-Dawley rats (≈250 g)[1] |
| Dosage: | 3 mg/kg, 10 mg/kg, 30 mg/kg |
| Administration: | Subcutaneously (s.c.); five days. |
| Result: | 30 mg/kg had lower corticosterone responses relative to 10 mg/kg at 15 and 30 min time points. |
References
[1] Elizabeth T Nguyen, et al. A Mixed Glucocorticoid/Mineralocorticoid Receptor Modulator Dampens Endocrine and Hippocampal Stress Responsivity in Male Rats. Physiol Behav. 2017 Sep 1;178:82-92. DOI:10.1016/j.physbeh.2017.01.020
CORT 118335 Preparation Products And Raw materials
Raw materials
Preparation Products
CORT 118335 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32268 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49734 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38663 | 58 | |
| WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd. | 17702719238 17702719238 | sales@sun-shinechem.com | China | 1042 | 64 |
| Kaixin Chemical (Hong Kong) Limited | 010-88886666-01 13112345678 | loyson@tcypharm.com | China | 596 | 55 |
| Shanghai Dexuan Pharmaceutical Technology Co., Ltd | 1701086315 | dexuanpharma@126.com | China | 9475 | 58 |
| Nantong QuanYi Biotechnology Co., Ltd | 0513-66337626 18051384581 | sales@chemhifuture.com | China | 5527 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 19965 | 58 |
View Lastest Price from CORT 118335 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-05-12 | Miricorilant
1400902-13-7
|
US $293.00-987.00 / mg | 98.62% | 10g | TargetMol Chemicals Inc. |
-
- Miricorilant
1400902-13-7
- US $293.00-987.00 / mg
- 98.62%
- TargetMol Chemicals Inc.