TVB-3166
- CAS No.
- 1533438-83-3
- Chemical Name:
- TVB-3166
- Synonyms
- TVB-3166;TVB-3166 ，S3576;TVB-3166,TVB3166;TVB-3166 >=98% (HPLC);TVB-3166, 10 mM in DMSO;TVB 3166,inhibit,TVB3166,Apoptosis,TVB-3166,Inhibitor,Fatty Acid Synthase (FASN);4-(1-(5-(4,5-Dimethyl-1H-pyrazol-3-yl)-2,4-dimethylbenzoyl)azetidin-3-yl)benzonitrile;Benzonitrile, 4-[1-[5-(4,5-dimethyl-1H-pyrazol-3-yl)-2,4-dimethylbenzoyl]-3-azetidinyl]-
- CBNumber:
- CB24670650
- Molecular Formula:
- C24H24N4O
- Molecular Weight:
- 384.47
- MDL Number:
- MOL File:
- 1533438-83-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 641.5±55.0 °C(Predicted) |
|---|---|
| Density | 1.26±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO:5.0(Max Conc. mg/mL);13.0(Max Conc. mM) |
| form | powder |
| pka | 14.66±0.50(Predicted) |
| color | white to beige |
| InChI | 1S/C24H24N4O/c1-14-9-15(2)22(10-21(14)23-16(3)17(4)26-27-23)24(29)28-12-20(13-28)19-7-5-18(11-25)6-8-19/h5-10,20H,12-13H2,1-4H3,(H,26,27) |
| InChIKey | ICDQFUFDAFKCAX-UHFFFAOYSA-N |
| SMILES | CC1=C(C2=C(C)C(C)=NN2)C=C(C(N3CC(C4=CC=C(C#N)C=C4)C3)=O)C(C)=C1 |
| UNSPSC Code | 41106300 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
| WGK Germany | WGK 3 |
| Storage Class | 11 - Combustible Solids |
TVB-3166 price More Price(38)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML1694 | TVB-3166 ≥98% (HPLC) | 1533438-83-3 | 5MG | $148 | 2026-04-30 | Buy |
| Sigma-Aldrich | SML1694 | TVB-3166 ≥98% (HPLC) | 1533438-83-3 | 25MG | $599 | 2026-04-30 | Buy |
| Cayman Chemical | 33533 | TVB-3166 ≥98% | 1533438-83-3 | 1mg | $38 | 2026-04-30 | Buy |
| Cayman Chemical | 33533 | TVB-3166 ≥98% | 1533438-83-3 | 5mg | $129 | 2026-04-30 | Buy |
| Cayman Chemical | 33533 | TVB-3166 ≥98% | 1533438-83-3 | 10mg | $183 | 2026-04-30 | Buy |
TVB-3166 Chemical Properties, Uses, Production
Uses
TVB-3166 is an orally-available, reversible, and selective fatty acid synthase (FASN) inhibitor with IC50s of 42 nM and 81 nM for biochemical FASN and cellular palmitate synthesis, respectively. TVB-3166 induces apoptosis, and inhibits in-vivo xenograft tumor growth[1].
Biochem/physiol Actions
TVB-3166 is a cell-permeable pyrrazole derivative that inhibits cellular palmitate synthesis (IC50 <100 nM) by fatty acid synthase (FASN) keto-reductase activity in a potent and reversible manner (IC50 = 42 nM), effectively inhibiting palmitate-dependent survival of various cancer cells in cultures and xenografted tumor growth in mice vivo (60-100 mg/kg/d p.o.), while exhibiting little or no anti-proliferation activity toward non-palmitate-dependent growth of cancer and non-cancer cultures. FASN inhibition by TVB-3166 treatment is also effective against the replications respiratory viruses both in cultures (Effc. conc. 200 nM against RSV and PIV3 in A549, HEp2, and HeLa cultures) and in mice (50 mg/kg/12 h, p.o.; RSV) in vivo without significant adverse effects to the host cells or mice.
in vivo
TVB-3166 (Oral gavage; 30-100 mg/kg/day) inhibits xenograft tumor growth[1].
TVB-3166 (Oral gavage; 30-100 mg/kg/day) has the concentration is approximately 3-fold higher in plasma than tumor. The 100 and 30 mg/kg groups had plasma and tumor concentrations of 7 and 2.9 μM, respectively[1].
| Animal Model: | Female BALB-c-nude mice[1] |
| Dosage: | 30, 60, or 100 mg/kg |
| Administration: | Oral gavage; once daily |
| Result: | Inhibited xenograft tumor growth. |
| Animal Model: | Female BALB-c-nude mice[1] |
| Dosage: | 30, 60, or 100 mg/kg (Pharmacokinetic Study) |
| Administration: | Oral gavage; once daily |
| Result: | The concentration was approximately 3-fold higher in plasma than tumor. The 100 and 30 mg/kg groups had plasma and tumor concentrations of 7 and 2.9 μM, respectively. |
References
[1] Ventura R, et al. Inhibition of de novo Palmitate Synthesis by Fatty Acid Synthase Induces Apoptosis in Tumor Cells by Remodeling Cell Membranes, Inhibiting Signaling Pathways, and Reprogramming Gene Expression. EBioMedicine. 2015 Jul 2;2(8):808-24. DOI:10.1016/j.ebiom.2015.06.020
TVB-3166 Preparation Products And Raw materials
Raw materials
Preparation Products
TVB-3166 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Guangzhou Isun Pharmaceutical Co., Ltd | 020-39119399 18927568969 | isunpharm@qq.com | China | 4773 | 55 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Shanghai XingMo Biotechnology Co., Ltd. | +86 13524779951; 13524779951 | 2075692521@qq.com | China | 294 | 55 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51389 | 80 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4866 | 55 | |
| Shanghaizehan biopharma technology co., Ltd. | 021-61350663 13052117465 | sales@zehanbiopharma.com | China | 989 | 55 |
| Shanghai Beckham Medical Technology Co., Ltd | 13816613772 | huahero21@sina.com | China | 2994 | 55 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Shanghai Rechem science Co., Ltd. | 021-31433387 15618786686 | sales@rechemscience.com | China | 2959 | 58 |
| Shanghai Chaolan Chemical Technology Center | QQ：65489617 13301690235 | Sales@ATKchemical.com | China | 9729 | 58 |
