BU 224 hydrochloride
- CAS No.
- 205437-64-5
- Chemical Name:
- BU 224 hydrochloride
- Synonyms
- BU224 HCl/205437-64-5;BU 224 hydrochloride, 10 mM in DMSO;2-(4,5-Dihydro-1H-imidazol-2-yl)quinoline hydrochloride;2-(4,5-Dihydro-1H-imidazol-2-yl)quinoline hydrochloride , BU224;BU 224 hydrochloride, Imidazoline I2 binding site allosteric modulator;BU 224,Tumor Necrosis Factor Receptor,inhibit,Inhibitor,BU224,Imidazoline,BU-224,TNF Receptor,Alzheimer's disease,TNFR,Apoptosis,BU 224 hydrochloride,anti-apoptotic,ACTH,antidepressant,neuroprotective,Imidazoline Receptor,5-HT,anti-inflammatory
- CBNumber:
- CB24718596
- Molecular Formula:
- C12H12ClN3
- Molecular Weight:
- 233.7
- MDL Number:
- MFCD00467639
- MOL File:
- 205437-64-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
BU 224 hydrochloride price More Price(40)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 42451 | BU 224 (hydrochloride) ≥95% | 205437-64-5 | 5mg | $54 | 2026-04-30 | Buy |
| Cayman Chemical | 42451 | BU 224 (hydrochloride) ≥95% | 205437-64-5 | 10mg | $103 | 2026-04-30 | Buy |
| Cayman Chemical | 42451 | BU 224 (hydrochloride) ≥95% | 205437-64-5 | 25mg | $244 | 2026-04-30 | Buy |
| Cayman Chemical | 42451 | BU 224 (hydrochloride) ≥95% | 205437-64-5 | 50mg | $432 | 2026-04-30 | Buy |
| Usbiological | 254830 | BU 224 Hydrochloride | 205437-64-5 | 10mg | $448 | 2026-06-03 | Buy |
BU 224 hydrochloride Chemical Properties, Uses, Production
Description
BU-224 is a Putative I2 antagonist; and a high affinity ligand for the imidazoline I2 binding site (Ki = 2.1 nM). BU224 reverses cognitive deficits, reduces microgliosis and enhances synaptic connectivity in a mouse model of Alzheimer's disease.
Uses
BU224 hydrochloride is a selective and high affinity imidazoline I2 receptor ligand, with a Ki of 2.1 nM. BU224 hydrochloride is sometimes used as an I2 receptor antagonist. BU224 hydrochloride exerts neuroprotective effects, with anti-inflammatory and anti-apoptotic properties. BU224 hydrochloride improves memory in 5XFAD mice, enlarging dendritic spines and reducing Aβ-induced changes in NMDARs. BU224 hydrochloride can be used for Alzheimer's disease research[1][2][3].
in vivo
BU224 hydrochloride (5 mg/kg, IP, twice a day for 10 days) improves behavioural performance and memory function in 5XFAD mice[1].
BU224 hydrochloride (5 mg/kg, IP, twice a day for 10 days) reduces levels of the microglial marker Iba1 and pro-inflammatory cytokines IL-1β and TNF-α and increased the expression of astrocytic marker GFAP in 5XFAD mice[1].
BU224 hydrochloride (10 mg/kg, IP, once) reduces immobility of rats in the FST (forced swim test), indicative of antidepressant-like activity[2].
| Animal Model: | 5XFAD mice and and WT littermates (6-month-old)[1] |
| Dosage: | 0 mg/kg, 5 mg/kg |
| Administration: | IP, twice a day for 10 days |
| Result: | Significantly increased immobility (54% increased freezing), and reversed memory deficits secondary to the deposition of Aβ in the brain. |
storage
Desiccate at RT
References
[1] Mirzaei N, et al. Imidazoline ligand BU224 reverses cognitive deficits, reduces microgliosis and enhances synaptic connectivity in a mouse model of Alzheimer's disease. Br J Pharmacol. 2021 Feb;178(3):654-671. DOI:10.1111/bph.15312
[2] Finn DP, et al. Behavioral, neuroendocrine and neurochemical effects of the imidazoline I2 receptor selective ligand BU224 in naive rats and rats exposed to the stress of the forced swim test. Psychopharmacology (Berl). 2003 May;167(2):195-202. DOI:10.1007/s00213-003-1392-3
[3] Qiu Y, et al. Discriminative stimulus effects of the imidazoline I2 receptor ligands BU224 and phenyzoline in rats. Eur J Pharmacol. 2015 Feb 15;749:133-41. DOI:10.1016/j.ejphar.2015.01.013
BU 224 hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
BU 224 hydrochloride Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Shanghai Chaolan Chemical Technology Center | QQ：65489617 13301690235 | Sales@ATKchemical.com | China | 9699 | 58 |
| BOC Sciences | 16314854226; +8616314854226 | inquiry@bocsci.com | United States | 19852 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Changzhou Chenhong Biotechnology Co., Ltd. | +86-0519-85788828 +86-13775037613 | sales@chemrenpharm.com | China | 4058 | 58 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8137 | 58 |
| Zhengzhou convergence chemical co., LTD | 037155153829 18003835034 | 3897192574@qq.com | China | 9982 | 58 |
| Bide Pharmatech Ltd. | 400-1647117 13681763483 | product02@bidepharm.com | China | 59929 | 58 |
| InvivoChem | 13549236410 | sales@invivochem.cn | China | 6745 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
