2-(4,5-Dihydro-1H-imidazol-2-yl)pyridine
- CAS No.
- 7471-05-8
- Chemical Name:
- 2-(4,5-Dihydro-1H-imidazol-2-yl)pyridine
- Synonyms
- 4,5-Dihydro-2-(pyridin-2-yl)-1H-imidazole;NSC 403538;2-(4,5-Dihydro-2-imidazolyl)pyridine;2-(4,5-Dihydro-1H-imidazol-2-yl)pyridine;Pyridine, 2-(4,5-dihydro-1H-imidazol-2-yl)-;2-(4,5-DIHYDRO-1H-IMIDAZOL-2-YL)PYRIDINE ISO 9001：2015 REACH
- CBNumber:
- CB41013355
- Molecular Formula:
- C8H9N3
- Molecular Weight:
- 147.18
- MDL Number:
- MOL File:
- Mol file
- MSDS File:
- SDS
| Melting point | 104-105℃ |
|---|---|
| Boiling point | 172-173℃ (6 Torr) |
| Density | 1.24±0.1 g/cm3 (20 ºC 760 Torr) |
| Flash point | 121.8±25.1℃ |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 8.92±0.40(Predicted) |
| color | Pale Yellow to Light Beige |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H319 |
| Precautionary statements | P305+P351+P338 |
2-(4,5-Dihydro-1H-imidazol-2-yl)pyridine price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | TRC-D177851-500MG | 2-(4,5-Dihydro-1h-imidazol-2-yl)pyridine | 7471-05-8 | 500mg | $320 | 2026-06-03 | Buy |
| TRC | TRC-D177851-250MG | 2-(4,5-Dihydro-1h-imidazol-2-yl)pyridine | 7471-05-8 | 250mg | $193 | 2026-06-03 | Buy |
| TRC | TRC-D177851-100MG | 2-(4,5-Dihydro-1h-imidazol-2-yl)pyridine | 7471-05-8 | 100mg | $97 | 2026-06-03 | Buy |
| Matrix Scientific | 299158 | 2-(4,5-Dihydro-1H-imidazol-2-yl)pyridine | 7471-05-8 | 100.00mg | $63 | 2026-05-19 | Buy |
| Matrix Scientific | 299158 | 2-(4,5-Dihydro-1H-imidazol-2-yl)pyridine | 7471-05-8 | 250.00mg | $78 | 2026-05-19 | Buy |
2-(4,5-Dihydro-1H-imidazol-2-yl)pyridine Chemical Properties, Uses, Production
Uses
2-(4,5-Dihydro-1H-imidazol-2-yl)pyridine is used in preparation of γ-lactam and δ-lactam by C-H amination.
Synthesis
100-70-9
107-15-3
7471-05-8
Typical reactions were carried out under microwave radiation conditions. A mixture of 2-cyanopyridine (10 mmol), ethylenediamine (40 mmol) and Cu(II)-(IAA)2 (2.0 mmol) was placed in a microwave reactor and irradiated with pulses at a power of 1000 W for 5-20 min. The reaction process was monitored by thin layer chromatography (TLC) with an eluent ratio of ethyl acetate/methanol (3:1). Upon completion of the reaction, the mixture was cooled to room temperature and diluted by addition of dichloromethane (CH2Cl2), followed by filtration to remove the catalyst. The solvent was removed by rotary evaporation to give almost pure 2-(4,5-dihydro-1H-imidazol-2-yl)pyridine. For further purification, the standard method for the synthesis of imidazolines under reflux conditions can be used. The structure of the product was confirmed by melting point (mp), nuclear magnetic resonance hydrogen spectroscopy (1H NMR), mass spectrometry (MS) and infrared spectroscopy (IR) data.
References
[1] Journal of the Serbian Chemical Society, 2012, vol. 77, # 9, p. 1181 - 1189,9
[2] Canadian Journal of Chemistry, 2010, vol. 88, # 2, p. 135 - 141
[3] Monatshefte fur Chemie, 2007, vol. 138, # 6, p. 579 - 583
[4] Tetrahedron Letters, 2011, vol. 52, # 14, p. 1578 - 1582
[5] Tetrahedron Letters, 2006, vol. 47, # 13, p. 2129 - 2132
2-(4,5-Dihydro-1H-imidazol-2-yl)pyridine Preparation Products And Raw materials
2-(4,5-Dihydro-1H-imidazol-2-yl)pyridine Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Synyoo New Materials Co., Ltd. | 0757-82582588 | sales@synyoo.com | China | 75 | 55 |
| Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. | 025-66028182 17714375163 | yftan@aikonchem.com | China | 16674 | 50 |
| Struchem Co., Ltd. | 0512-63009836 18994340901 | helen@struchem.com | China | 3970 | 60 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Hangzhou Molcore Biopharmatech Co.,Ltd | 400-711-5280 86-571-81025280 | sales@molcore.com | China | 9957 | 58 |
| 9ding chemical ( Shanghai) Limited | 021-021-52271985 17721149837 | sales@9dingchem.com | China | 19780 | 60 |
| Suzhou Nuoouman Biological Technology Co., Ltd. | 15026866316 | 180642609@qq.com | China | 4966 | 58 |
| Zhengzhou Ruke Biological Co., Ltd. | 15981811963 | 1410472904@qq.com | China | 5824 | 58 |
| Henan Alfachem Co.,Ltd. | 0371-55051623 18137891487 | 3983243027@qq.com | China | 9971 | 58 |
| Yujinpharma(Tianjin) Technology Co.,Ltd. | 13370351217 kungfu1217@1 | kungfu1217@163.com | China | 7994 | 58 |
View Latest Price from 2-(4,5-Dihydro-1H-imidazol-2-yl)pyridine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-20 | 2-(4,5-DIHYDRO-1H-IMIDAZOL-2-YL)PYRIDINE
7471-05-8
|
$1.10 | 1g | 99.00% | 100 Tons Min | Dideu Industries Group Limited |
-
- 2-(4,5-DIHYDRO-1H-IMIDAZOL-2-YL)PYRIDINE
7471-05-8
- $1.10
- 99.00%
- Dideu Industries Group Limited
