COR 170
- CAS No.
- 1048039-15-1
- Chemical Name:
- COR 170
- Synonyms
- COR 170;N-(Adamant-1-yl)-4-oxo-1-pentyl-6-phenyl-1,4-dihydroquinoline-3-carboxamide;3-Quinolinecarboxamide, 1,4-dihydro-4-oxo-1-pentyl-6-phenyl-N-tricyclo[3.3.1.13,7]dec-1-yl-
- CBNumber:
- CB24725033
- Molecular Formula:
- C31H36N2O2
- Molecular Weight:
- 468.63
- MDL Number:
- MFCD27991277
- MOL File:
- 1048039-15-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
COR 170 price More Price(11)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 255028 | COR 170 Asreported | 1048039-15-1 | 10mg | $475 | 2026-06-03 | Buy |
| Usbiological | 255028 | COR 170 Asreported | 1048039-15-1 | 50mg | $1316 | 2026-06-03 | Buy |
| Biosynth | YRB03915 | COR 170 | 1048039-15-1 | 25mg | $750.25 | 2026-06-05 | Buy |
| Biosynth | YRB03915 | COR 170 | 1048039-15-1 | 50mg | $1200.5 | 2026-06-05 | Buy |
| Biosynth | YRB03915 | COR 170 | 1048039-15-1 | 100mg | $1671 | 2026-06-05 | Buy |
COR 170 Chemical Properties, Uses, Production
Description
Selective inverse agonist of CB2 receptors (Ki values are 3.8 and >10,000 nM for CB2 and CB1, respectively).
Uses
COR170 (11u) is a selective CB2 inverse-agonist which is a 4-quinolone-3-carboxylic acid derivative with a Ki value of 3.8 nM for CB2 receptor. COR170 can be used for the research of inflammation and neuroprotection[1][2][3].
in vivo
COR170 (11u) (1.5-6 mg/kg; i.p, once) reduces the late phase nociceptive behaviour induced by formalin[3].
| Animal Model: | Mice with formalin (1.25%, 30 μL) injections[3] |
| Dosage: | 1.5, 3 and 6 mg/kg |
| Administration: | Intraperitoneal injection; 1.5, 3 and 6 mg/kg for once |
| Result: | Reduced the late phase nociceptive behaviour induced by formalin with a 6 mg/kg dose and 10 min before formalin and abolished the analgesic effect from GW405833 which is a CB2 receptor partial agonist. |
storage
Store at RT
References
[1] Contartese A, et al. A novel CB2 agonist, COR167, potently protects rat brain cortical slices against OGD and reperfusion injury. Pharmacol Res. 2012 Dec;66(6):555-63. DOI:10.1016/j.phrs.2012.08.003
[2] Pasquini S, et al. Investigations on the 4-quinolone-3-carboxylic acid motif. 2. Synthesis and structure-activity relationship of potent and selective cannabinoid-2 receptor agonists endowed with analgesic activity in vivo. J Med Chem. 2008 Aug 28;51(16): DOI:10.1021/jm800552f
[3] Cascio MG, et al. In vitro and in vivo pharmacological characterization of two novel selective cannabinoid CB(2) receptor inverse agonists. Pharmacol Res. 2010 Apr;61(4):349-54. DOI:10.1016/j.phrs.2009.11.011
COR 170 Preparation Products And Raw materials
Raw materials
Preparation Products
COR 170 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | 16314854226; +8616314854226 | inquiry@bocsci.com | United States | 19852 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Nantong Hi-Future Biotechnology Co., Ltd | +86-0513; 18051384581 | sales@chemhifuture.com | China | 3075 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
| Shanghai Tachizaki Biomedical Research Center | 18014399201 | sales@chemlab-tachizaki.com | China | 2934 | 58 |
| TargetMol Chemicals Inc. | 13564774135 | marketing@targetmol.com | United States | 19950 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 50068 | 58 | |
| Wuhan Topule Biopharmaceutical Co., Ltd | +86-18327326525 | masar@topule.com | China | 8433 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +86-18051384581 | sales@chemhifuture.com | China | 3123 | 58 |
