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Sitagliptin Impurity 12

Sitagliptin Impurity 12 structure

CAS No.: 1803026-54-1

Chemical Name:: Sitagliptin Impurity 12

Synonyms: Sitagliptin EP Impurity 12;(Z)-1-(3-(trifluoromethyl);(2Z)-1-[5,6-Dihydro-3-(trifluoromethyl)-1;(2Z)-1-[5,6-Dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-α]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)-2-buten-1-one;2-Buten-1-one, 1-[5,6-dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)-, (2Z)-;(Z)-1-(3-(Trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)but-2-en-1-one (Sitagliptin Impurity)

CBNumber:: CB24842022

Molecular Formula:: C16H12F6N4O

Molecular Weight:: 390.28

MDL Number:

MOL File:: 1803026-54-1.mol

Last updated:2023-05-15 10:44:01

Product description	Number	Pack Size	Price
(2Z)-1-[5,6-Dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)-2-buten-1-one	422231	10mg	$425
(2Z)-1-[5,6-Dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)-2-buten-1-one	422231	25mg	$722
(2Z)-1-[5,6-Dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-α]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)-2-buten-1-one	ID183167	50mg	$6490
(2Z)-1-[5,6-Dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-α]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)-2-buten-1-one	ID183167	100mg	$8567
(2Z)-1-[5,6-Dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-α]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)-2-buten-1-one	ID183167	250mg	$14927.5

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Sitagliptin Impurity 12 Properties

Boiling point	517.5±60.0 °C(Predicted)
Density	1.52±0.1 g/cm3(Predicted)
solubility	soluble in Chloroform, DCM, Methanol
pka	-0.06±0.20(Predicted)
form	Oil
color	Light Yellow

Sitagliptin Impurity 12 price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Usbiological	422231	(2Z)-1-[5,6-Dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)-2-buten-1-one	1803026-54-1	10mg	$425	2026-06-03	Buy
Usbiological	422231	(2Z)-1-[5,6-Dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)-2-buten-1-one	1803026-54-1	25mg	$722	2026-06-03	Buy
Biosynth	ID183167	(2Z)-1-[5,6-Dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-α]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)-2-buten-1-one	1803026-54-1	50mg	$6490	2026-06-04	Buy
Biosynth	ID183167	(2Z)-1-[5,6-Dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-α]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)-2-buten-1-one	1803026-54-1	100mg	$8567	2026-06-04	Buy
Biosynth	ID183167	(2Z)-1-[5,6-Dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-α]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)-2-buten-1-one	1803026-54-1	250mg	$14927.5	2026-06-04	Buy

Product number	Packaging	Price	Buy
422231	10mg	$425	Buy
422231	25mg	$722	Buy
ID183167	50mg	$6490	Buy
ID183167	100mg	$8567	Buy
ID183167	250mg	$14927.5	Buy

Sitagliptin Impurity 12 Chemical Properties,Uses,Production

Uses

(2Z)-1-[5,6-Dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)-2-buten-1-one is an intermediate in the synthesis of 3-Desamino-2,3-dehydro Sitagliptin (D281985),an impurity of Sitagliptin (S491000). Sitagliptin is a trizolopyrazine dipeptidyl peptidase IV inhibitor. Sitagliptin has recently been approved for the therapy of type II diabetes.

Sitagliptin Impurity 12 Preparation Products And Raw materials

Raw materials

Preparation Products

Sitagliptin Impurity 12 Suppliers

Global( 11)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
BOC Sciences	16314854226; +8616314854226	inquiry@bocsci.com	United States	19852	58
Henan Kehong Biological Technology Co. LTD	0371-86658258 18638736641	info@kehobio.com	China	2767	58
Molcoo Chemicals Inc.	18627923403	3001039764@qq.com	China	8359	58
Shanghai YuZn Pharm. Technology Co.,Ltd.	15921286451; 15921286451	2010681527@qq.com	China	4920	58
Shanghai Zerui Biotechnology Co., Ltd.	021-54580889 18321124657	1054713992@qq.com	China	10598	58
ShenZhen H&D Pharmaceutical Technology Co., LTD	18126517264	2850476883@qq.com	China	7948	58
Hubei Moco Chemical Co., Ltd.	18627753421; 18627756402	3001051413@qq.com	China	20013	58
Taizhou Chuanxu Pharmaceutical Technology Co., Ltd.	chuanxupharma@126.co	chuanxupharma@126.com	China	9982	58

Supplier	Advantage
BOC Sciences	58
Henan Kehong Biological Technology Co. LTD	58
Molcoo Chemicals Inc.	58
Shanghai YuZn Pharm. Technology Co.,Ltd.	58
Shanghai Zerui Biotechnology Co., Ltd.	58
ShenZhen H&D Pharmaceutical Technology Co., LTD	58
Hubei Moco Chemical Co., Ltd.	58
Taizhou Chuanxu Pharmaceutical Technology Co., Ltd.	58

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1of4

(Z)-1-(3-(trifluoromethyl) 2-Buten-1-one, 1-[5,6-dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)-, (2Z)- Sitagliptin EP Impurity 12 (2Z)-1-[5,6-Dihydro-3-(trifluoromethyl)-1 (Z)-1-(3-(Trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)but-2-en-1-one (Sitagliptin Impurity) (2Z)-1-[5,6-Dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-α]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)-2-buten-1-one 1803026-54-1