Canakinumab
- CAS No.
- 914613-48-2
- Chemical Name:
- Canakinumab
- Synonyms
- ACZ885;Ilaris;ACZ-885;ACZ 885;Canakinumab;ACZ 885|||Ilaris;Canakinumab (Anti-IL-1b);Research Grade Canakinumab;Anti-Human IL-1B(Canakinumab);Research Grade Canakinumab(DHB95601)
- CBNumber:
- CB24845962
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- Mol file
- MSDS File:
- SDS
| storage temp. | Store at -20°C |
|---|---|
| form | Liquid |
| color | Colorless to light yellow |
| FDA UNII | 37CQ2C7X93 |
| NCI Drug Dictionary | canakinumab |
| ATC code | L04AC08 |
Canakinumab price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | BC176794 | Canakinumab - in PBS buffer approx. 15mg/ml | 914613-48-2 | 1mg | $998.25 | 2026-06-04 | Buy |
| ChemScene | CS-0031090 | Canakinumab 98.84% | 914613-48-2 | 1mg | $238 | 2026-06-04 | Buy |
| ChemScene | CS-0031090 | Canakinumab 98.84% | 914613-48-2 | 5mg | $758 | 2026-06-04 | Buy |
| Biorbyt Ltd | orb1983526 | Canakinumab Antibody 98.8%(SDS-PAGE);98.3%(SEC-HPLC) | 914613-48-2 | 1mg | $220 | 2026-05-06 | Buy |
| Biorbyt Ltd | orb1983526 | Canakinumab Antibody 98.8%(SDS-PAGE);98.3%(SEC-HPLC) | 914613-48-2 | 5mg | $620 | 2026-05-06 | Buy |
Canakinumab Chemical Properties,Uses,Production
Uses
Canakinumab (ACZ885) is a recombinant human anti-IL-1β monoclonal antibody. Canakinumab shows IC50 values of 43.6 and 40.8 pM for human and marmoset IL-1β, respectively. The mode of action of canakinumab is based on the neutralization of IL-1β signaling, resulting in suppression of inflammation related to disorders of autoimmune origin[1][2].
References
[1] Dhimolea E. Canakinumab. MAbs. Epub 2010 Jan 15. DOI:10.4161/mabs.2.1.10328
[2] Rondeau JM, et al. The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1β. MAbs. 2015;7(6):1151-60. DOI:10.1080/19420862.2015.1081323
Canakinumab Preparation Products And Raw materials
Raw materials
Preparation Products
Canakinumab Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Wuhan Maixi Biotechnology Co., Ltd | 18007167883 18007167883 | Service@mabnus.com | China | 921 | 58 |
| Chembest Research Laboratories Limited | 021-20908456 | sales@BioChemBest.com | China | 5996 | 61 |
| Wuhan Sunrise Technology Development Co., Ltd. | 27-027-83314682 13554138826 | whsrtech@vip.163.com | China | 140 | 62 |
| Dalian Meilun Biotech Co., Ltd. | 0411-62910999 13889544652 | sales@meilune.com | China | 4765 | 58 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| ShangHai Biochempartner Co.,Ltd | 177-54423994 17754423994 | 2853530910@QQ.com | China | 8000 | 62 |
| BOC Sciences | 16314854226; +8616314854226 | inquiry@bocsci.com | United States | 19852 | 58 |
| Guangzhou Hongyuan Chemical Co.,Ltd | 15817493340 | 981810490@qq.com | China | 1577 | 58 |
| Wuhan Chemstan Biotechnology Co., Ltd. | 027-65317797 15926423062 | 422450190@qq.com | China | 10305 | 58 |
