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| | Canakinumab Basic information |
| Product Name: | Canakinumab | | Synonyms: | Canakinumab;Anti-Human IL-1B(Canakinumab);Research Grade Canakinumab(DHB95601);ACZ 885;ACZ885;ACZ-885;Ilaris;Canakinumab (Anti-IL-1b) | | CAS: | 914613-48-2 | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![Canakinumab Structure]() |
| | Canakinumab Chemical Properties |
| storage temp. | Store at -20°C | | form | Liquid | | color | Colorless to light yellow |
| | Canakinumab Usage And Synthesis |
| Uses | Canakinumab (ACZ885) is a recombinant human anti-IL-1β monoclonal antibody. Canakinumab shows IC50 values of 43.6 and 40.8 pM for human and marmoset IL-1β, respectively. The mode of action of canakinumab is based on the neutralization of IL-1β signaling, resulting in suppression of inflammation related to disorders of autoimmune origin[1][2]. | | References | [1] Dhimolea E. Canakinumab. MAbs. Epub 2010 Jan 15. DOI:10.4161/mabs.2.1.10328
[2] Rondeau JM, et al. The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1β. MAbs. 2015;7(6):1151-60. DOI:10.1080/19420862.2015.1081323 |
| | Canakinumab Preparation Products And Raw materials |
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