Ixekizumab
- CAS No.
- 1143503-69-8
- Chemical Name:
- Ixekizumab
- Synonyms
- LY2439821;Ixekizumab;Ixekizumab (anti-CTLA-8);Research Grade Ixekizumab;Research Grade Ixekizumab(DHH28801)
- CBNumber:
- CB24845997
- Molecular Formula:
- N/A
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- Mol file
- MSDS File:
- SDS
| storage temp. | Store at 4°C, do not freeze |
|---|---|
| form | Liquid |
| color | Colorless to light yellow |
| FDA UNII | BTY153760O |
| ATC code | L04AC13 |
Ixekizumab price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0031038 | Ixekizumab 99.00% | 1143503-69-8 | 1mg | $141 | 2026-06-04 | Buy |
| ChemScene | CS-0031038 | Ixekizumab 99.00% | 1143503-69-8 | 5mg | $498 | 2026-06-04 | Buy |
| ChemScene | CS-0031038 | Ixekizumab 99.00% | 1143503-69-8 | 10mg | $823 | 2026-06-04 | Buy |
| ChemScene | CS-0031038 | Ixekizumab 99.00% | 1143503-69-8 | 25mg | $1733 | 2026-06-04 | Buy |
| ChemScene | CS-0031038 | Ixekizumab 99.00% | 1143503-69-8 | 50mg | $2773 | 2026-06-04 | Buy |
Ixekizumab Chemical Properties,Uses,Production
Description
Ixekizumab (Taltz) is a biologic medication used to treat psoriatic arthritis, plaque psoriasis, ankylosing spondylitis, and non-radiographic axial spondyloarthritis. Biologic medications are proteins designed by humans that affect the immune system. Ixekizumab blocks the inflammatory protein IL-17A. This improves joint pain and swelling from arthritis and rash in psoriatic conditions.
Uses
Ixekizumab (LY2439821) is a humanized IgG4 monoclonal antibody that selectively binds and neutralizes interleukin IL-17A (KD<3 pM). Ixekizumab directly blocks IL-17A binding to IL-17RA (IL-17A receptor) but does not bind to other IL-17 family members. Ixekizumab is used for the research of moderate-to-severe plaque psoriasis[1][2].
Indications
Ixekizumab is FDA-indicated for the adult treatment of moderate to severe plaque psoriasis, active psoriatic arthritis, active ankylosing spondylitis, and active non-radiographic axial spondyloarthritis with objective signs of inflammation.
Side effects
Ixekizumab can lower the ability of your immune system to fight infections. If you develop symptoms of an infection while using this medication, you should stop it and contact your rheumatology provider. All patients should be tested for tuberculosis and hepatitis before starting on ixekizumab. The most common side effects are infections, injection site reactions, upper respiratory infections, and lowering of white blood cells called neutropenia. Rare cases of inflammatory bowel disease (Crohn’s disease or ulcerative colitis) have been seen. Ixekizumab has not been studied in pregnancy or breastfeeding.
in vivo
Ixekizumab (0.001-1 mg/kg; i.v.) is able to decrease human IL-17A-induced keratinocyte chemoattractant (KC) secretion in the plasma of the C57BL/6 mice in a dose-dependent manner[1].
In male cynomolgus monkeys, following IV administration of 1 mg/kg, Ixekizumab is eliminated with a mean half-life of 6.5 days. After SC administration of 1 mg/kg, Ixekizumab reaches an average maximal plasma concentration of 11.1 μg/mL ~72 hours postdose. The mean elimination half-life following the SC injection was 10.3 days[1].
| Animal Model: | C57BL/6 mice (n=5 per group, 8-12-week old, subcutaneous injection of human IL-17A)[1] |
| Dosage: | 1 mg/kg, 0.1 mg/kg, 0.01 mg/kg, or 0.001 mg/kg (corresponding to 20 μg, 2 μg, 0.2 μg, and 0.02 μg per mouse, respectively) |
| Administration: | I.v.; 1 hour prior to a subcutaneous (SC) injection of human IL-17A |
| Result: | Decrease human IL-17A-induced KC secretion in the plasma of the C57BL/6 mice in a dose-dependent manner. |
IC 50
IL-17
References
[1] G. AVALLONE. Real-life comparison between secukinumab and ixekizumab in the treatment of pustular and erythrodermic psoriasis[J]. Journal of the European Academy of Dermatology and Venereology, 2022, 36 7: e574-e576. DOI:10.1111/jdv.18069.
[2] A. PALLER. Long-term Efficacy and Safety of Up to 108 Weeks of Ixekizumab in Pediatric Patients With Moderate to Severe Plaque Psoriasis[J]. JAMA dermatology, 2022, 158 1: 533-541. DOI:10.1001/jamadermatol.2022.0655.
[3] https://rheumatology.org/patients/ixekizumab-taltz
[4] https://www.ncbi.nlm.nih.gov/books/NBK431088/
Ixekizumab Preparation Products And Raw materials
Raw materials
Preparation Products
Ixekizumab Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Wuhan Sunrise Technology Development Co., Ltd. | 27-027-83314682 13554138826 | whsrtech@vip.163.com | China | 140 | 62 |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 9920 | 65 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| ShangHai Biochempartner Co.,Ltd | 177-54423994 17754423994 | 2853530910@QQ.com | China | 8000 | 62 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Guangzhou Hongyuan Chemical Co.,Ltd | 15817493340 | 981810490@qq.com | China | 1577 | 58 |
| Wuhan Chemstan Biotechnology Co., Ltd. | 027-65317797 15926423062 | 422450190@qq.com | China | 10305 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 | psaitong@jm-bio.com | China | 27626 | 58 |
| Hubei Kele Fine Chemical Co., Ltd | 027-59101668 19945030958 | 2223443625@qq.com | China | 7996 | 58 |
View Lastest Price from Ixekizumab manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-27 | Ixekizumab
1143503-69-8
|
$106.00-378.00 | 98.86% (SEC-HPLC) | 10g | TargetMol Chemicals Inc. |
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- Ixekizumab
1143503-69-8
- $106.00-378.00
- 98.86% (SEC-HPLC)
- TargetMol Chemicals Inc.
