ALK-4290
- CAS No.
- 1251528-23-0
- Chemical Name:
- ALK-4290
- Synonyms
- ALK-4290;BI-144807;AKST-4290;4-Pyridinecarboxamide, 2-[[[(2R)-1-[1-[(4-chloro-3-methylphenyl)methyl]-4-piperidinyl]-5-oxo-2-pyrrolidinyl]carbonyl]amino]-N,N,6-trimethyl-;2-[[[(2R)-1-[1-[(4-Chloro-3-methylphenyl)methyl]-4-piperidinyl]-5-oxo-2-pyrrolidinyl]carbonyl]amino]-N,N,6-trimethyl-4-pyridinecarboxamide (ACI)
- CBNumber:
- CB24918271
- Molecular Formula:
- C27H34ClN5O3
- Molecular Weight:
- 512.04
- MDL Number:
- MFCD34470690
- MOL File:
- 1251528-23-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 743.8±60.0 °C(Predicted) |
|---|---|
| Density | 1.288±0.06 g/cm3(Predicted) |
| pka | 11.94±0.20(Predicted) |
| form | Solid |
| color | White to off-white |
| FDA UNII | R0T9LLR4TN |
ALK-4290 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0133685 | ALK4290 99.79% | 1251528-23-0 | 5mg | $704 | 2026-06-04 | Buy |
| ChemScene | CS-0133685 | ALK4290 99.79% | 1251528-23-0 | 10mg | $1062 | 2026-06-04 | Buy |
| ChemScene | CS-0133685 | ALK4290 99.79% | 1251528-23-0 | 25mg | $2221 | 2026-06-04 | Buy |
| ChemScene | CS-0133685 | ALK4290 99.79% | 1251528-23-0 | 50mg | $3575 | 2026-06-04 | Buy |
| ChemScene | CS-0133685 | ALK4290 99.79% | 1251528-23-0 | 100mg | $5741 | 2026-06-04 | Buy |
ALK-4290 Chemical Properties, Uses, Production
Uses
ALK4290 (AKST4290) is a potent and orally active CCR3 inhibitor extracted from patent US20130261153A1, compound Example 2, with a Ki of 3.2 nM for hCCR3[1]. ALK4290 can be used for the research of neovascular age-related macular degeneration and Parkinsonism[2][3].
IC 50
CCR3: 3.2 nM (Ki)
References
[1] NIVENS MC, et, al. Use of ccr3-inhibitors. US20130261153A1.
[2] Samanta A, te, al. Emerging Therapies in Neovascular Age-Related Macular Degeneration in 2020. Asia Pac J Ophthalmol (Phila). May-Jun 2020; 9(3):250-259. DOI:10.1097/APO.0000000000000291
[3] Clinical Development of AKST4290 as a Novel Parkinson’s Therapeutic
ALK-4290 Preparation Products And Raw materials
Raw materials
Preparation Products
ALK-4290 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Kaixin Chemical (Hong Kong) Limited | 010-88886666-01 13112345678 | loyson@qq.com | China | 589 | 55 |
| BOC Sciences | 16314854226; +8616314854226 | inquiry@bocsci.com | United States | 19852 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11963 | 58 |
| Shanghai?Medlife?Pharm-Tech?Co.,?Ltd | 4000862158 18117107507 | vip@med-life.cn | China | 4999 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29874 | 58 |
| Qingdao Haizhi Weiyuan Biotechnology Co., Ltd. | 18317699790 18317699790 | l202008112023@163.com | China | 7733 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 38999 | 58 |
