Trichloromethanesulfonyl chloride
- CAS No.
- 2547-61-7
- Chemical Name:
- Trichloromethanesulfonyl chloride
- Synonyms
- Trichloromesyl chloride.;Trichlor-methansulfonylchlorid;trichloro-methanesulfonylchlorid;TRICHLOROMETHANESULFONYL CHLORIDE;trichloromethanesulphonyl chloride;Methanesulfonyl chloride, trichloro-;Trichloromethanesulfonyl Chloride >Trichloromethanesulfonyl chloride,pract.;TRICHLOROMETHANESULFONYL CHLORIDE, TECH.;trichloromethanesulfonyl chloride CCl4O2S
- CBNumber:
- CB2495941
- Molecular Formula:
- CCl4O2S
- Molecular Weight:
- 217.89
- MDL Number:
- MFCD00007452
- MOL File:
- 2547-61-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 137-140 °C(lit.) |
|---|---|
| Boiling point | 170°C |
| Density | 1.8252 (estimate) |
| solubility | soluble in Toluene |
| form | solid |
| color | White to Almost white |
| InChI | 1S/CCl4O2S/c2-1(3,4)8(5,6)7 |
| InChIKey | ZCPSWAFANXCCOT-UHFFFAOYSA-N |
| SMILES | ClC(Cl)(Cl)S(Cl)(=O)=O |
| CAS DataBase Reference | 2547-61-7(CAS DataBase Reference) |
| NIST Chemistry Reference | Methanesulfonyl chloride, trichloro-(2547-61-7) |
| EPA Substance Registry System | Methanesulfonyl chloride, trichloro- (2547-61-7) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS07 |
|---|---|
| Signal word | Danger |
| Hazard statements | H314-H335 |
| Precautionary statements | P260-P271-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338 |
| target organs | Respiratory system |
| PPE | Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges |
| Hazard Codes | C |
| Risk Statements | 34-36/37 |
| Safety Statements | 26-27-28-36/37/39-45 |
| RIDADR | UN 3261 8/PG 2 |
| WGK Germany | 3 |
| TSCA | TSCA listed |
| HS Code | 2904.10.5000 |
| HazardClass | 8 |
| PackingGroup | III |
| Storage Class | 8A - Combustible corrosive hazardous materials |
| Hazard Classifications | Eye Dam. 1 Skin Corr. 1B STOT SE 3 |
Trichloromethanesulfonyl chloride price More Price(16)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 235962 | Trichloromethanesulfonyl chloride 97% | 2547-61-7 | 5g | $120 | 2023-01-07 | Buy |
| TCI Chemical | T0611 | Trichloromethanesulfonyl Chloride >95.0%(T) | 2547-61-7 | 5g | $82 | 2026-04-30 | Buy |
| TCI Chemical | T0611 | Trichloromethanesulfonyl Chloride >95.0%(T) | 2547-61-7 | 25g | $262 | 2026-04-30 | Buy |
| Apolloscientific | OR72500 | Trichloromethanesulfonyl chloride >95% | 2547-61-7 | 250mg | $21 | 2026-06-04 | Buy |
| Apolloscientific | OR72500 | Trichloromethanesulfonyl chloride >95% | 2547-61-7 | 1g | $33 | 2026-06-04 | Buy |
Trichloromethanesulfonyl chloride Chemical Properties,Uses,Production
Application
Trichloromethanesulfonyl chloride can be used as a pharmaceutical synthesis intermediate. Perfluoroiodoalkanes and bromoalkanes undergo sulfinization-deiodination and debromination reactions with sodium dithionite under appropriate conditions, while perfluorochloroalkanes do not react under similar conditions. However, carbon tetrachloride and 1,1,1-trichloropolyfluoroalkanes can undergo sulfinization-dechlorination reactions with sodium dithionite. Trichlorobromomethane and trichloroiodomethane react under similar conditions to yield sulfinized debromination and deiodination products, respectively.
Uses
Trichloromethanesulfonyl chloride is an efficient free radical chlorinating agent. It reacts with pent-4-enylcobaloximes in inert solvent under tugsten lamp irradiation to yield 2-(β,β,β- trichloroethyl)sulfolanes. It also reacts with trimethylsilyl enol ethers of acetophenones in the presence of a ruthenium (II) phosphine complex to yield 1-aryl-3,3-dichloropropen-1-one and α-chloroacetophenones.
General Description
Trichloromethanesulfonyl chloride is an efficient free radical chlorinating agent. It reacts with pent-4-enylcobaloximes in inert solvent under tugsten lamp irradiation to yield 2-(β,β,β- trichloroethyl)sulfolanes. It also reacts with trimethylsilyl enol ethers of acetophenones in the presence of a ruthenium (II) phosphine complex to yield 1-aryl-3,3-dichloropropen-1-one and α-chloroacetophenones.
Synthesis
Step 1); reaction at 25C, under nitrogen atmosphere, 4.0g (26mmol) la, 4.6g (26mmol) sodium thiosulfate, 2.2g sodium bicarbonate, 18mL of water and 6mL of ethyl ether, stirred at 25C for 6h and then replenished with 2.3g of sodium thiosulfate, 1.1g of sodium bicarbonate, and continued to react for l0h, evaporated the solvent under reduced pressure, and extracted the leftover residual with 50mL of ethyl acetate. The solid was extracted three times with 50 mL of ethyl acetate, and the extract was de-esterified to give a white fluffy solid, which was crystallized by isopropanol to give 3.9 g of colorless crystals 2a in 73% yield. Step 2): 3.9g2a was dissolved in 15mL water, reacted with chlorine at 0 for lh, precipitated white solid, filtered, washed, dried, purified by sublimation method, obtained 3.9g of white solid trichloromethylsulfonyl chloride, yield 94%.
Trichloromethanesulfonyl chloride Preparation Products And Raw materials
Raw materials
Preparation Products
Trichloromethanesulfonyl chloride Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Hunan Hui Bai Shi Biotechnology Co., Ltd. | 0731-85526065 13308475853 | ivy@hnhbsj.com | China | 7236 | 62 |
| Chengdu Ai Keda Chemical Technology Co., Ltd. | 4008-755-333 18080918076 | 800078821@qq.com | China | 9706 | 55 |
| Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. | 025-66113011 13913916777 | cfzhang@aikonchem.com | China | 19902 | 55 |
| TOKYO CHEMICAL INDUSTRY CO., LTD. | 03-36680489 | Sales-JP@TCIchemicals.com | Japan | 28364 | 80 |
