CYCLIC-PIFITHRIN-ALPHA
- CAS No.
- 60477-34-1
- Chemical Name:
- CYCLIC-PIFITHRIN-ALPHA
- Synonyms
- Pifithrin-2;Pifithrin-alpha (cyclic) . HBr;Pifithrin-β (QB-102 and Cyclic-Pifithrin-α);Pifithrin-α, Cyclic- - CAS 60477-34-1 - Calbiochem;Pifithrin-α, Cyclic- - CAS 60477-34-1 - Calbiochem;2-(p-Tolyl)-5,6,7,8-tetrahydrobenzo[d]imidazo[2,1-b]thiazole;5,6,7,8-Tetrahydro-2-(4-methylphenyl)-imidazo[2,1-b]benzothiazole;Imidazo[2,1-b]benzothiazole, 5,6,7,8-tetrahydro-2-(4-methylphenyl)-
- CBNumber:
- CB2504209
- Molecular Formula:
- C16H16N2S
- Molecular Weight:
- 268.38
- MDL Number:
- MFCD02108837
- MOL File:
- 60477-34-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 266.4-267.3 °C(lit.) |
|---|---|
| Density | 1.30±0.1 g/cm3(Predicted) |
| storage temp. | −20°C |
| solubility | DMSO: 20 mg/mL |
| form | White solid |
| pka | 6.75±0.20(Predicted) |
| color | white |
| FDA UNII | 45I8QO7K37 |
| UNSPSC Code | 12352200 |
CYCLIC-PIFITHRIN-ALPHA price More Price(22)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 045150 | Pifithrin-alpha (cyclic) hydrobromide (2-(4-Methylphenyl)imidazo-5,6,7,8-tetrahydrobenzothiazole . HBr) >98%(NMR) | 60477-34-1 | 5mg | $290 | 2026-06-03 | Buy |
| Usbiological | 045150 | Pifithrin-alpha (cyclic) hydrobromide (2-(4-Methylphenyl)imidazo-5,6,7,8-tetrahydrobenzothiazole . HBr) >98%(NMR) | 60477-34-1 | 10mg | $395 | 2026-06-03 | Buy |
| Usbiological | 045150 | Pifithrin-alpha (cyclic) hydrobromide (2-(4-Methylphenyl)imidazo-5,6,7,8-tetrahydrobenzothiazole . HBr) >98%(NMR) | 60477-34-1 | 50mg | $695 | 2026-06-03 | Buy |
| Biosynth | KCA47734 | Pifithrin-² | 60477-34-1 | 25mg | $982.75 | 2026-06-04 | Buy |
| Biosynth | KCA47734 | Pifithrin-² | 60477-34-1 | 50mg | $1367.5 | 2026-06-04 | Buy |
CYCLIC-PIFITHRIN-ALPHA Chemical Properties, Uses, Production
Uses
Pifithrin-β (PFT β) is a potent p53 inhibitor with an IC50 of 23 μM.
Definition
ChEBI: 2-(4-methylphenyl)-5,6,7,8-tetrahydroimidazo[2,1-b][1,3]benzothiazole is a member of imidazoles.
General Description
A cell-permeable and very stable analog of Pifithrin-α (Cat. No. 506132), with similar biological function, but with reduced cytotoxicity. A chemical inhibitor of p53. Reversibly inhibits p53-dependent transactivation of p53-responsive genes; also reversibly blocks p53-mediated apoptosis. Acts as a P-gp modulator by changing relative substrate specificity of the transporter. This compound has been reported to be a potent STAT6 transcriptional inhibitor.
Biochem/physiol Actions
Cell permeable: yes
References
[1] Christodoulou MS, et al. Synthesis and biological evaluation of imidazolo[2,1-b]benzothiazole derivatives, as potential p53 inhibitors. Bioorg Med Chem. 2011 Mar 1;19(5):1649-57. DOI:10.1016/j.bmc.2011.01.039
[2] Fernández-Cruz ML, et al. Biological and chemical studies on aryl hydrocarbon receptor induction by the p53 inhibitor pifithrin-α and its condensation product pifithrin-β. Life Sci. 2011 Apr 25;88(17-18):774-83. DOI:10.1016/j.lfs.2011.02.019
[3] Da Pozzo E, et al. p53 functional inhibitors behaving like pifithrin-β counteract the Alzheimer peptide non-β-amyloid component effects in human SH-SY5Y cells. ACS Chem Neurosci. 2014 May 21;5(5):390-9.
CYCLIC-PIFITHRIN-ALPHA Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2915 | 55 | |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 9920 | 65 |
| MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4853 | 58 |
| Shanghai Tauto Biotech Co., Ltd. | 021-51320588 | tauto@tautobiotech.com | China | 3984 | 66 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51389 | 80 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Shanghai QianYan Bio-technology Co., Ltd | 02781293128 | orders@biochemsafebuy.com | China | 9904 | 55 |
| Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 9780 | 55 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Musechem | +1-800-259-7612 | info@musechem.com | United States | 4648 | 60 |
