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1H-INDOLE-5-CARBOXAMIDE, 97%

1H-INDOLE-5-CARBOXAMIDE, 97% structure

CAS No.: 1670-87-7

Chemical Name:: 1H-INDOLE-5-CARBOXAMIDE, 97%

Synonyms: SD-169;SD169 ，S0388;5-CarbaMoylindole;SD-169, 10 mM in DMSO;1H-indole-5-carboxamide;5-(AMinocarbonyl)-1H-indole;1H-Indole-5-carboxamide(9CI);1H-INDOLE-5-CARBOXAMIDE, 97%;1H-indole-5-carboxamide(SD-169);Indole-5-carboxamide (7CI, 8CI)

CBNumber:: CB0972248

Molecular Formula:: C9H8N2O

Molecular Weight:: 160.17

MDL Number:: MFCD07779486

MOL File:: 1670-87-7.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-04-22 18:57:36

Product description	Number	Pack Size	Price
p38 MAP Kinase Inhibitor VII, SD-169	506158	10mg	$238
SD 169 ≥97%	14156	5mg	$41
SD 169 ≥97%	14156	10mg	$69
SD 169 ≥97%	14156	25mg	$157
SD 169 ≥97%	14156	5mg	$37
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1H-INDOLE-5-CARBOXAMIDE, 97% Properties

Melting point	159-163 °C
Boiling point	457.6±18.0 °C(Predicted)
Density	1.328±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,2-8°C
solubility	DMSO (Slightly), Methanol (Slightly)
pka	16.25±0.30(Predicted)
form	Off-white solid
color	Off-White to Light Purple
Water Solubility	water: 1mg/mL DMSO: 10mg/mL
InChI	1S/C9H8N2O/c10-9(12)7-1-2-8-6(5-7)3-4-11-8/h1-5,11H,(H2,10,12)
InChIKey	GQMYQEAXTITUAE-UHFFFAOYSA-N
SMILES	[nH]1c2c(cc1)cc(cc2)C(=O)N
UNSPSC Code	51111800
NACRES	NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H315-H319-H335

Precautionary statements

P261-P264-P270-P301+P312-P302+P352-P305+P351+P338

target organs

Respiratory system

Hazard Codes

Risk Statements

22-36/37/38

Safety Statements

WGK Germany

WGK 3

Storage Class

11 - Combustible Solids

Hazard Classifications

Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

NFPA 704

	0
2		0

1H-INDOLE-5-CARBOXAMIDE, 97% price More Price(45)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	506158	p38 MAP Kinase Inhibitor VII, SD-169	1670-87-7	10mg	$238	2026-04-30	Buy
Cayman Chemical	14156	SD 169 ≥97%	1670-87-7	5mg	$41	2026-04-30	Buy
Cayman Chemical	14156	SD 169 ≥97%	1670-87-7	10mg	$69	2026-04-30	Buy
Cayman Chemical	14156	SD 169 ≥97%	1670-87-7	25mg	$157	2026-04-30	Buy
Cayman Chemical	14156	SD 169 ≥97%	1670-87-7	5mg	$37	2024-03-01	Buy

Product number	Packaging	Price	Buy
506158	10mg	$238	Buy
14156	5mg	$41	Buy
14156	10mg	$69	Buy
14156	25mg	$157	Buy
14156	5mg	$37	Buy

1H-INDOLE-5-CARBOXAMIDE, 97% Chemical Properties,Uses,Production

Uses

SD 169 is a selective ATP competitive inhibitor of the MAP kinases p38α (IC50 = 3.2 nM) and p38β (IC50 = 122 nM). It has no inhibitory effect against a panel of other kinases, including p38γ MAP kinase, ERK2, JNK-1, and MAPKAPK-2, when tested in vitro at 50 μM. SD 169 is orally active, significantly reducing p38 MAP kinase expression in T cells of nonobese diabetic mice when delivered in chow at 600 mg/kg. In this model, SD 169 also reduced the incidence of diabetes, lowered blood glucose, and improved glucose homeostasis. SD 169 also enhances axonal regeneration after sciatic nerve crush injury in rats, when given by gavage (30 mg/kg) before and after nerve damage.

Uses

1H-Indole-5-carboxamide (SD-169) is a p38α MAPK-selective inhibitor. 1H-Indole-5-carboxamide (SD-169) prevents the development and progression of diabetes in nonobese diabetic (NOD) mice by inhibiting T cell infiltration and activation.

Definition

ChEBI: 1H-indole-5-carboxamide is an indolecarboxamide.

Biological Activity

Selective, orally active, ATP-competitive inhibitor of p38 α MAPK (IC 50 values are 3.2, 122 and > 50000 nM for p38 α , p38 β and p38 γ respectively). Demonstrates no activity against a range of other kinases including ERK2, JNK1 and MAPKAP2. Prevents development of diabetes and alleviates mild and moderate hyperglycaemic states in NOD mice.

IC 50

p38α MAPK: 3.2 nM (IC₅₀); p38β MAPK: 122 nM (IC₅₀)

References

[1] medicherla s, protter a a, ma j y, et al. preventive and therapeutic potential of p38α-selective mitogen-activated protein kinase inhibitor in nonobese diabetic mice with type 1 diabetes[j]. journal of pharmacology and experimental therapeutics, 2006, 318(1): 99-107.
[2] myers r r, sekiguchi y, kikuchi s, et al. inhibition of p38 map kinase activity enhances axonal regeneration[j]. experimental neurology, 2003, 184(2): 606-614.

1H-INDOLE-5-CARBOXAMIDE, 97% Preparation Products And Raw materials

Raw materials

Preparation Products

1H-INDOLE-5-CARBOXAMIDE, 97% Suppliers

Global( 129)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Nanjing ChemLin Chemical Industry Co., Ltd.	025-83697070	product@chemlin.com.cn	CHINA	3009	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
Nanjing jinheyou Trading Co., Ltd.	15705188088	admin@jheyou.com	CHINA	1268	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29794	58
TargetMol Chemicals Inc.	+1-781-999-5354; +17819995354	marketing@targetmol.com	United States	32467	58
Hubei Ipure Biology Co., Ltd	+8613367258412	ada@ipurechemical.com	China	10236	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418671 +8618949823763	sales@tnjchem.com	China	34563	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6312	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6391	58

Supplier	Advantage
Nanjing ChemLin Chemical Industry Co., Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
Alchem Pharmtech,Inc.	58
Nanjing jinheyou Trading Co., Ltd.	58
career henan chemical co	58
TargetMol Chemicals Inc.	58
Hubei Ipure Biology Co., Ltd	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	58
InvivoChem	58

View Lastest Price from 1H-INDOLE-5-CARBOXAMIDE, 97% manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-04-22	SD-169 1670-87-7	US $51.00-75.00 / mg		99.78%	10g	TargetMol Chemicals Inc.
2021-07-02	1H-INDOLE-5-CARBOXAMIDE, 97% 1670-87-7	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd
2020-01-13	1H-INDOLE-5-CARBOXAMIDE 1670-87-7	US $1.00 / g	1g	98%	100KG	Career Henan Chemical Co

SD-169
1670-87-7
US $51.00-75.00 / mg
99.78%
TargetMol Chemicals Inc.

1H-INDOLE-5-CARBOXAMIDE, 97%
1670-87-7
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

1H-INDOLE-5-CARBOXAMIDE
1670-87-7
US $1.00 / g
98%
Career Henan Chemical Co

1H-INDOLE-5-CARBOXAMIDE, 97% Spectrum

1H-INDOLE-5-CARBOXAMIDE, 97%(1670-87-7)¹HNMR

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1H-INDOLE-5-CARBOXAMIDE, 97% SD-169 1H-Indole-5-carboxamide(9CI) 5-(AMinocarbonyl)-1H-indole 5-CarbaMoylindole p38 MAP Kinase Inhibitor VII, SD-169 5-(Aminocarbonyl)-1H-indole, 5-Carbamoylindole, 5-Carboxamidoindole p38 MAP Kinase Inhibitor VII, SD-169 - CAS 1670-87-7 - Calbiochem Indole-5-carboxamide (7CI, 8CI) HSPs,p38α,kinases,SD-169,protein,inhibit,Inhibitor,p38 MAPK,MAPK,SD169,heat,diabete,mitogen-activated,proteins,shock 1H-indole-5-carboxamide(SD-169) SD 169, ATP-competitive p38alpha MAPK inhibitor SD-169, 10 mM in DMSO SD169 ，S0388 1H-indole-5-carboxamide 1670-87-7 AMIDE Heterocyclic Compounds