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1H-Indole-5-carboxamide, 97%

1H-Indole-5-carboxamide, 97% Structure
1H-Indole-5-carboxamide, 97% structure
CAS No.
1670-87-7
Chemical Name:
1H-Indole-5-carboxamide, 97%
Synonyms
SD-169;SD169 ，S0388;5-CarbaMoylindole;SD-169, 10 mM in DMSO;1H-indole-5-carboxamide;5-(AMinocarbonyl)-1H-indole;1H-Indole-5-carboxamide(9CI);1H-Indole-5-carboxamide, 97%;1H-indole-5-carboxamide(SD-169);Indole-5-carboxamide (7CI, 8CI)
CBNumber:
CB0972248
Molecular Formula:
C9H8N2O
Molecular Weight:
160.17
MDL Number:
MFCD07779486
MOL File:
1670-87-7.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-09-12 18:48:31
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1H-Indole-5-carboxamide, 97% Properties

Melting point 159-163 °C
Boiling point 457.6±18.0 °C(Predicted)
Density 1.328±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,2-8°C
solubility DMSO (Slightly), Methanol (Slightly)
form Off-white solid
pka 16.25±0.30(Predicted)
color Off-White to Light Purple
Water Solubility water: 1mg/mL
DMSO: 10mg/mL
InChI 1S/C9H8N2O/c10-9(12)7-1-2-8-6(5-7)3-4-11-8/h1-5,11H,(H2,10,12)
InChIKey GQMYQEAXTITUAE-UHFFFAOYSA-N
SMILES [nH]1c2c(cc1)cc(cc2)C(=O)N
UNSPSC Code 51111800
NACRES NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P264-P270-P301+P312-P302+P352-P305+P351+P338
target organs Respiratory system
Hazard Codes  Xn
Risk Statements  22-36/37/38
Safety Statements  26
WGK Germany  WGK 3
Storage Class 11 - Combustible Solids
Hazard Classifications Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
NFPA 704
0
2 0

1H-Indole-5-carboxamide, 97% price More Price(67)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 506158 p38 MAP Kinase Inhibitor VII, SD-169 1670-87-7 10mg $238 2026-04-30 Buy
Cayman Chemical 14156 SD 169 ≥97% 1670-87-7 5mg $41 2026-04-30 Buy
Cayman Chemical 14156 SD 169 ≥97% 1670-87-7 10mg $69 2026-04-30 Buy
Cayman Chemical 14156 SD 169 ≥97% 1670-87-7 25mg $157 2026-04-30 Buy
Usbiological 238984 Indole-5-carboxamide 1670-87-7 250mg $206 2026-06-03 Buy
Product number Packaging Price Buy
506158 10mg $238 Buy
14156 5mg $41 Buy
14156 10mg $69 Buy
14156 25mg $157 Buy
238984 250mg $206 Buy

1H-Indole-5-carboxamide, 97% Chemical Properties,Uses,Production

Uses

SD 169 is a selective ATP competitive inhibitor of the MAP kinases p38α (IC50 = 3.2 nM) and p38β (IC50 = 122 nM). It has no inhibitory effect against a panel of other kinases, including p38γ MAP kinase, ERK2, JNK-1, and MAPKAPK-2, when tested in vitro at 50 μM. SD 169 is orally active, significantly reducing p38 MAP kinase expression in T cells of nonobese diabetic mice when delivered in chow at 600 mg/kg. In this model, SD 169 also reduced the incidence of diabetes, lowered blood glucose, and improved glucose homeostasis. SD 169 also enhances axonal regeneration after sciatic nerve crush injury in rats, when given by gavage (30 mg/kg) before and after nerve damage.

Uses

1H-Indole-5-carboxamide (SD-169) is a p38α MAPK-selective inhibitor. 1H-Indole-5-carboxamide (SD-169) prevents the development and progression of diabetes in nonobese diabetic (NOD) mice by inhibiting T cell infiltration and activation.

Definition

ChEBI: 1H-indole-5-carboxamide is an indolecarboxamide.

Biological Activity

Selective, orally active, ATP-competitive inhibitor of p38 α MAPK (IC 50 values are 3.2, 122 and > 50000 nM for p38 α , p38 β and p38 γ respectively). Demonstrates no activity against a range of other kinases including ERK2, JNK1 and MAPKAP2. Prevents development of diabetes and alleviates mild and moderate hyperglycaemic states in NOD mice.

IC 50

p38α MAPK: 3.2 nM (IC50); p38β MAPK: 122 nM (IC50)

References

[1] medicherla s, protter a a, ma j y, et al. preventive and therapeutic potential of p38α-selective mitogen-activated protein kinase inhibitor in nonobese diabetic mice with type 1 diabetes[j]. journal of pharmacology and experimental therapeutics, 2006, 318(1): 99-107.
[2] myers r r, sekiguchi y, kikuchi s, et al. inhibition of p38 map kinase activity enhances axonal regeneration[j]. experimental neurology, 2003, 184(2): 606-614.

1H-Indole-5-carboxamide, 97% Preparation Products And Raw materials

Raw materials

Preparation Products

1H-Indole-5-carboxamide, 97% Suppliers

Global( 134)Suppliers
Supplier Tel Email Country ProdList Advantage
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
3B Pharmachem (Wuhan) International Co.,Ltd. 18930552037 3bsc@sina.com China 15813 69
Carbott PharmTech Inc. 0535-6385396 info@carbottpharm.com China 996 56
VDM Biochemicals 0330-2528181 sales@vdmbio.com United States 510 64
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
Chemsky（shanghai）International Co.,Ltd. 021-50135380 shchemsky@sina.com China 32273 50
Syntechem Co.,Ltd info@syntechem.com China 12973 57
BOC Sciences 1-631-485-4226; 16314854226 info@bocsci.com United States 9920 65
SYN|thesis med chem P/L +86-021-50720296 service@synkinase.com China 266 58
Bide Pharmatech Ltd. 400-164-7117 18317119277 product02@bidepharm.com China 40000 60
Supplier Advantage
J & K SCIENTIFIC LTD. 76
3B Pharmachem (Wuhan) International Co.,Ltd. 69
Carbott PharmTech Inc. 56
VDM Biochemicals 64
Shanghai Hanhong Scientific Co.,Ltd. 64
Chemsky（shanghai）International Co.,Ltd. 50
Syntechem Co.,Ltd 57
BOC Sciences 65
SYN|thesis med chem P/L 58
Bide Pharmatech Ltd. 60

View Lastest Price from 1H-Indole-5-carboxamide, 97% manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
SD-169 pictures 2026-08-08 SD-169
1670-87-7
 $29.00 99.78% 10g TargetMol Chemicals Inc.
1H-INDOLE-5-CARBOXAMIDE, 97% pictures 2021-07-02 1H-INDOLE-5-CARBOXAMIDE, 97%
1670-87-7
 $10.00-15.00 1KG 99%+ HPLC Zhuozhou Wenxi import and Export Co., Ltd
1H-INDOLE-5-CARBOXAMIDE pictures 2020-01-13 1H-INDOLE-5-CARBOXAMIDE
1670-87-7
 $1.00 1g 98% 100KG Career Henan Chemical Co
  • SD-169 pictures
  • SD-169
    1670-87-7
  • $29.00
  • 99.78%
  • TargetMol Chemicals Inc.

1H-Indole-5-carboxamide, 97% Spectrum

1H-INDOLE-5-CARBOXAMIDE, 97%(1670-87-7)1HNMR

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SD-169 1H-Indole-5-carboxamide(9CI) 5-(AMinocarbonyl)-1H-indole 5-CarbaMoylindole p38 MAP Kinase Inhibitor VII, SD-169 5-(Aminocarbonyl)-1H-indole, 5-Carbamoylindole, 5-Carboxamidoindole p38 MAP Kinase Inhibitor VII, SD-169 - CAS 1670-87-7 - Calbiochem Indole-5-carboxamide (7CI, 8CI) HSPs,p38α,kinases,SD-169,protein,inhibit,Inhibitor,p38 MAPK,MAPK,SD169,heat,diabete,mitogen-activated,proteins,shock 1H-indole-5-carboxamide(SD-169) SD 169, ATP-competitive p38alpha MAPK inhibitor SD-169, 10 mM in DMSO SD169 ，S0388 1H-indole-5-carboxamide 1H-Indole-5-carboxamide, 97% 1670-87-7 AMIDE Heterocyclic Compounds