4-(3-Bromophenyl)morpholine
- CAS No.
- 197846-82-5
- Chemical Name:
- 4-(3-Bromophenyl)morpholine
- Synonyms
- 4-(3-Bromophenyl)morpholine;4-(3-bromophenyl)morpholino;N-(3-BroMophenyl)Morpholine;1-(3-bromophenyl)-morpholine;Morpholine,4-(3-broMophenyl)-;4-(3-Bromophenyl)morpholine96%;1-BROMO-3-(4-MORPHOLINO)BENZENE;4-(3-Bromophenyl)morpholine 96%;1-Bromo-3-(morpholin-4-yl)benzene
- CBNumber:
- CB2664877
- Molecular Formula:
- C10H12BrNO
- Molecular Weight:
- 242.11
- MDL Number:
- MFCD04112585
- MOL File:
- 197846-82-5.mol
- MSDS File:
- SDS
| Boiling point | 341.1±37.0 °C(Predicted) |
|---|---|
| Density | 1.433 |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| pka | 4.02±0.40(Predicted) |
| form | liquid |
| color | Clear, brown |
| InChI | 1S/C10H12BrNO/c11-9-2-1-3-10(8-9)12-4-6-13-7-5-12/h1-3,8H,4-7H2 |
| InChIKey | RQMIVKDXRGZOBQ-UHFFFAOYSA-N |
| SMILES | Brc1cccc(c1)N2CCOCC2 |
| UNSPSC Code | 12352200 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H332-H335 | |||||||||
| Precautionary statements | P261-P280-P305+P351+P338 | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 22 | |||||||||
| WGK Germany | WGK 3 | |||||||||
| Hazard Note | Irritant | |||||||||
| HS Code | 2934999090 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral | |||||||||
| NFPA 704 |
|
4-(3-Bromophenyl)morpholine price More Price(44)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | CDS003639 | 1-bromo-3-(4-morpholino)benzene AldrichCPR | 250 mg | $77.9 | 2026-04-30 | Buy | |
| Apolloscientific | OR8531 | 4-(3-Bromophenyl)morpholine 96% | 197846-82-5 | 1g | $21 | 2026-06-04 | Buy |
| Apolloscientific | OR8531 | 4-(3-Bromophenyl)morpholine 96% | 197846-82-5 | 5g | $69 | 2026-06-04 | Buy |
| Apolloscientific | OR8531 | 4-(3-Bromophenyl)morpholine 96% | 197846-82-5 | 25g | $297 | 2026-06-04 | Buy |
| Activate Scientific | AS42667 | 4-(3-Bromophenyl)morpholine 96% | 197846-82-5 | 1g | $29 | 2026-06-04 | Buy |
4-(3-Bromophenyl)morpholine Chemical Properties, Uses, Production
Synthesis
110-91-8
108-36-1
197846-82-5
1,3-Dibromobenzene (50 g, 0.21 mol) and morpholine (15.89 mL, 0.19 mol) were used as raw materials, and both were added to the reaction flask with anhydrous toluene (200 mL) via a syringe under argon protection. After thorough mixing, R-BINAP (1.32 g, 0.0021 mol), palladium(0) dibenzylideneacetone (0.640 g, 0.006 mol) and DBU (25.8 mL, 0.17 mol) were added sequentially. The reaction mixture was stirred at 60 °C, followed by the addition of sodium tert-butoxide (30.55 g, 0.32 mol) and the reaction temperature was raised to 100 °C and continued overnight. Upon completion of the reaction, the suspension was diluted with ethyl acetate, filtered through diatomaceous earth and the organic phase was washed sequentially with water and brine. The organic phase was dried over anhydrous magnesium sulfate and concentrated under reduced pressure to remove the solvent. The crude product was purified by silica gel column chromatography with the eluent ethyl acetate:hexane (1:1) to afford the target compound 4-(3-bromophenyl)morpholine as a yellow oil (36.5 g, 71% yield). Mass spectrometry (ES+) showed the molecular ion peak m/z 242 ([M+H]+).
References
[1] Patent: WO2011/144578, 2011, A1. Location in patent: Page/Page column 28
[2] Journal of Medicinal Chemistry, 2015, vol. 58, # 14, p. 5522 - 5537
[3] Tetrahedron, 2008, vol. 64, # 13, p. 2938 - 2950
[4] Patent: WO2011/144577, 2011, A1. Location in patent: Page/Page column 25-26
4-(3-Bromophenyl)morpholine Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Shijiazhuang Sdyano Fine Chemical Co., Ltd. | 0311-89250318 13582355795 | master@sjzsdyn.com | China | 2776 | 65 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16305 | 64 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| China DongFan Chemical Co.,LTD | 86-0571-85151182 | China | 5681 | 66 | |
| Shandong Xiya Chemical Co., Ltd | 13355009207 13355009207 | 3007715519@qq.com | China | 18722 | 57 |
| Shanghai Ennopharm Co., Ltd. | +86 (21) 6435-5022 | China | 4263 | 65 |
View Latest Price from 4-(3-Bromophenyl)morpholine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-12-25 | 4-(3-BROMOPHENYL)MORPHOLINE
197846-82-5
|
$1.00 | 1KG | 99% | 200kg | Career Henan Chemical Co |
-
- 4-(3-BROMOPHENYL)MORPHOLINE
197846-82-5
- $1.00
- 99%
- Career Henan Chemical Co
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