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4-Chloro-3,5-dimethylphenol

4-Chloro-3,5-dimethylphenol Structure
4-Chloro-3,5-dimethylphenol structure
CAS No.
88-04-0
Chemical Name:
4-Chloro-3,5-dimethylphenol
Synonyms
PCMX;CHLOROXYLENOL;4-CHLORO-3,5-XYLENOL;Para-chloro-meta-xylenol;Dettol;nipacidemx;P-CHLORO-M-XYLENOL;Dimethyl-4-chlorophenol;PXMC;Camel
CBNumber:
CB2666624
Molecular Formula:
C8H9ClO
Molecular Weight:
156.61
MDL Number:
MFCD00002324
MOL File:
88-04-0.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-09-12 08:01:22
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4-Chloro-3,5-dimethylphenol Properties

Melting point 114-116 °C(lit.)
Boiling point 246 °C
Density 0.67 g/cm3
refractive index 1.5523 (estimate)
Flash point 132 °C
storage temp. 2-8°C
solubility methanol: soluble1g/10 mL, clear to faintly turbid, colorless to very faintly yellow
pka 9.76±0.23(Predicted)
form Crystalline Powder or Crystals
color White to light beige
PH 7 (0.2g/l, H2O)
Odor wh. cryst. or cryst. powd., char. phenolic odor
Water Solubility 0.3 g/L (20 ºC)
Merck 14,2176
BRN 1862539
Henry's Law Constant 1.9×101 mol/(m3Pa) at 25℃, HSDB (2015)
Stability Stable. Incompatible with strong oxidizing agents.
Cosmetics Ingredients Functions PRESERVATIVE
ANTIMICROBIAL
DEODORANT
Cosmetic Ingredient Review (CIR) 4-Chloro-3,5-dimethylphenol (88-04-0)
InChI 1S/C8H9ClO/c1-5-3-7(10)4-6(2)8(5)9/h3-4,10H,1-2H3
InChIKey OSDLLIBGSJNGJE-UHFFFAOYSA-N
SMILES Cc1cc(O)cc(C)c1Cl
LogP 3.270
CAS DataBase Reference 88-04-0(CAS DataBase Reference)
Indirect Additives used in Food Contact Substances CHLOROXYLENOL
FDA 21 CFR 175.105
EWG's Food Scores 3
FDA UNII 0F32U78V2Q
ATC code D08AE05
NIST Chemistry Reference Chloroxylenol(88-04-0)
EPA Substance Registry System 4-Chloro-3,5-dimethylphenol (88-04-0)
UNSPSC Code 41116107
NACRES NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H317-H319
Precautionary statements  P280-P301+P312+P330-P302+P352-P305+P351+P338
PPE dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Hazard Codes  Xn,Xi
Risk Statements  22-36/38-43
Safety Statements  24-37
RIDADR  UN 3077 9/PG 3
WGK Germany  1
RTECS  ZE6850000
Hazard Note  Irritant
TSCA  TSCA listed
HazardClass  9
PackingGroup  III
HS Code  29081000
Storage Class 11 - Combustible Solids
Hazard Classifications Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
Skin Sens. 1
Hazardous Substances Data 88-04-0(Hazardous Substances Data)
Toxicity LD50 orally in Rabbit: 3830 mg/kg
REACH Registrations Active
NFPA 704
0
2 0

4-Chloro-3,5-dimethylphenol price More Price(62)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich Y0002463 Chloroxylenol for system suitability CRS (European Pharmacopoeia (EP) Reference Standard) 88-04-0 55 mg $137 2026-04-30 Buy
Sigma-Aldrich Y0002462 Chloroxylenol CRS (European Pharmacopoeia (EP) Reference Standard) 88-04-0 160 mg $137 2026-04-30 Buy
Sigma-Aldrich BP080 Chloroxylenol British Pharmacopoeia (BP) Reference Standard 88-04-0 500MG $241 2026-04-30 Buy
Sigma-Aldrich 8.18734 4-Chloro-3,5-dimethylphenol for synthesis 88-04-0 250g $63 2026-04-30 Buy
Sigma-Aldrich 24380 4-Chloro-3,5-dimethylphenol purum, ≥98.0% (T) 88-04-0 1kg $206 2026-04-30 Buy
Product number Packaging Price Buy
Y0002463 55 mg $137 Buy
Y0002462 160 mg $137 Buy
BP080 500MG $241 Buy
8.18734 250g $63 Buy
24380 1kg $206 Buy

4-Chloro-3,5-dimethylphenol Chemical Properties, Uses, Production

Description

Chloroxylenol is a bactericide and antiseptic used mainly in public health situations. Available data is limited. It is moderately toxic to aquatic species. Mammalian toxicity is low and, whilst it may be an eye irritant, no data is available that suggests it may cause more serious health impacts.

Chemical Properties

4-Chloro-3,5-dimethylphenol is white or cream crystalline powder with a characteristic odour

Chemical Properties

White or cream-colored crystals or crystalline powder with a characteristic phenolic odor. Volatile in steam.

Originator

Septiderm ,Fougera ,US,1960

Uses

antibacterial, topical and urinary antiseptic

Uses

4-Chloro-3,5-dimethylphenol is an antiseptic and germicide. Chloroxylenol is used for mildew prevention. Chloroxylenol is also an antibacterial; antiseptic (topical and urinary).

Uses

Antiseptic and germicide; for mildew prevention. Claimed to be about 60 times as potent as phenol.

Definition

ChEBI: 4-chloro-3,5-dimethylphenol is a member of the class of phenols that is 3,5-xylenol which is substituted at position 4 by chlorine. It is bactericidal against most Gram-positive bacteria but less effective against Staphylococci and Gram-negative bacteria, and often inactive against Pseudomonas species. It is ineffective against bacterial spores. It has a role as an antiseptic drug, a disinfectant and a molluscicide. It is a member of phenols and a member of monochlorobenzenes. It is functionally related to a 3,5-xylenol.

Production Methods

Chloroxylenol is prepared by treating 3,5-dimethylphenol with chlorine or sulfuryl chloride (SO2Cl2).

Manufacturing Process

546 g of intermediate xylenol fraction having a crystallizing point of 45°C mixed with an equal weight of m-5-xylenol are placed in a suitable vessel, equipped with stirring gear, and 273 g of sulfuryl chloride are added slowly. The temperature rises in the course of the reaction to about 40°C. When all the sulfuryl chloride is added the reaction mixture is heated to 80°C and theacid gases removed as far as possible by air-blowing or any other suitable means. On cooling a quantity of the required chlor-xylenol separates out and is removed from the mother liquor. Further quantities of the material required can be isolated by vacuum distillation of the mother liquors and further crystallization. In all, 200 to 208 g of material substantially 2-chlor-m-5- xylenol can be obtained having a melting point of 112°C to 115°C. The material can be purified if desired by crystallization from a solvent such as a hydrocarbon.

Therapeutic Function

Topical antiseptic; Disinfectant

General Description

The degradation of 4-chloro-3,5-dimethylphenol (PCMX) by Fenton-like process using nanoparticulate zero-valent iron (nZVI) and hydrogen peroxide (H2O2) was studied.

Agricultural Uses

Microbiocide: 4-Chloro-3,5-dimethylphenol was first registered in the U.S. for use as a fungicide and is now applied as an antimicrobial for control of bacteria, algae and fungi in adhesives, emulsions, paints and wash tanks. It is registered for use in household and domestic dwellings, laundry equipment, bathrooms, diaper pails and in industrial water and aqueous systems. Not listed for use in EU countries. Registered for use in the U.S. There are 64 global suppliers.

Pharmaceutical Applications

4-Chloro-3,5-dimethylphenol is a common constituent of many proprietary disinfectants used for skin and wound disinfection.
As a pharmaceutical excipient, 4-Chloro-3,5-dimethylphenol is commonly used in low concentrations as an antimicrobial preservative in topical formulations such as creams and ointments. 4-Chloro-3,5-dimethylphenol is also used in a number of cosmetic formulations.
Therapeutically, 4-Chloro-3,5-dimethylphenol has been investigated as a treatment for acne vulgaris, for treating infected root canals, and as an antifungal agent when impregnated into medical devices. 4-Chloro-3,5-dimethylphenol is included in drug products approved for topical antifungal, topical acne and topical dandruff/seborrheic dermatitis/psoriasis treatments.

Trade name

BAR-FUNGAL PLUS®[C]; BIO SLIME®[C]; DESSON®; DETTOL®; ECOTRU®; ESPADOL®; HUSEPT®; HUSEPT EXTRA®; NIPACIDE®; OTTASEPT®[C]; OTTASEPT® EXTRA[C]; PCMX; RBA 777®

Mechanism of action

Causes disruption of cell membrane potentials, blocking production of adenosine triphosphate

Clinical Use

p-Chloro-m-xylenol (PC-MX; Metasep) is a nonirritating antiseptic agent with broad-spectrum antibacterial and antifungal properties. It is marketed in a 2% concentration as a shampoo. It has also been used topically for the treatment of tinea (ringworm) infections such as athlete s foot (tinea pedis) and jock itch (tinea cruris).

Safety Profile

Poison by intraperitoneal route. Moderately toxic by ingestion. An experimental teratogen. An eye irritant. An antimicrobial agent. See also CHLOROPHENOLS and CHLORINATED HYDROCARBONS, AROMATIC. When heated to decomposition it emits toxic fumes of Cl-.

Safety

Chloroxylenol is generally regarded as a relatively nontoxic and nonirritant material when used as an excipient in topical products. However, chloroxylenol has been placed in Toxicity Category I for eye irritation effects. In addition, allergic skin reactions have been reported. Taken orally, chloroxylenol is mildly toxic and ingestion of a chloroxylenol-containing disinfectant product has been associated with reports of fatal or severe instances of selfpoisoning.
LD50 (mouse, IP): 0.115 g/kg
LD50 (rat, dermal): >2.0 g/kg
LD50 (rat, oral): 3.83 g/kg

storage

Chloroxylenol is stable at normal room temperature, but is volatile in steam. Contact with natural rubber should be avoided. Aqueous solutions of chloroxylenol are susceptible to microbial contamination and appropriate measures should be taken to prevent contamination during storage or dilution. Chloroxylenol should be stored in polyethylene, mild steel or stainless steel containers, which should be well-closed and kept in a cool, dry place. Chloroxylenol does not absorb at wavelengths >290 nm and has been reported to be stable to sunlight for up to 24 hours.

Purification Methods

Crystallise the phenol from *benzene or toluene. [Beilstein 6 IV 3152.]

Incompatibilities

4-Chloro-3,5-dimethylphenol has been reported to be incompatible with nonionic surfactants and methylcellulose.

Regulatory Status

Included in the FDA Inactive Ingredients Database (otic preparations; topical creams and emulsions). Included in nonparenteral medicines licensed in the UK. Approved in Europe as a preservative in cosmetics with a maximum authorized concentration of 0.5%.

References

[1] Journal of Organic Chemistry, 2017, vol. 82, # 14, p. 7529 - 7537
[2] Patent: US2350677, 1940,
[3] Fortsch. Ch., Phys., 1924, vol. 18, p. 38,51
[4] Journal of the Chemical Society [Section] C: Organic, 1970, p. 1982 - 1986

Pesticide Type

Fungicide; Veterinary substance

4-Chloro-3,5-dimethylphenol synthesis

108-68-9
88-04-0
Synthesis of 4-Chloro-3,5-dimethylphenol from 3,5-Dimethylphenol

4-Chloro-3,5-dimethylphenol Preparation Products And Raw materials

Raw materials

ZINC Xylenol Sulfuryl chloride CHLOROXYLENOL RELATED COMPOUND A (25 MG) (2- CHLORO-3,5-DIMETHYLPHENOL) 2,4-Dichloro-3,5-dimethylphenol
1,2-Dithiolane 3,5-Dimethylphenol Dichloromethane Ferric chloride Chloroform

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Preparation Products

4-Chloro-3,5-dimethylphenol Suppliers

Global Suppliers ( 705)
Supplier Tel Email Country ProdList Advantage
Powerful Chemical (Shanghai) Co., Ltd. 021-62211590 18917958225; pwfchem@163.com China 75 58
Jinan Wald Chemical Co., Ltd. 0531-88773586 13210588999 304264064@qq.com China 192 58
Panjin Jiahe Shengshi Pharmaceutical Technology Co., Ltd 13464671885 13032431717 sale@jhssw.com China 45 58
Shandong Suihua Biotechnology Co. Ltd 15689727968 freesky2121@163.com China 987 58
Henan Kaixin Biomedical Co., Ltd. 18135767668 18135767668 1101014211@qq.com China 832 58
Shandong Suihua Biotechnology Co., Ltd. 15169101773 15169101773 519904247@qq.com China 1077 58
Shanghai Boyle Chemical Co., Ltd. 021-50182298 021-50180596 sales@boylechem.com China 2202 55
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
3B Pharmachem (Wuhan) International Co.,Ltd. 18930552037 3bsc@sina.com China 15813 69
Supplier Advantage
Powerful Chemical (Shanghai) Co., Ltd. 58
Jinan Wald Chemical Co., Ltd. 58
Panjin Jiahe Shengshi Pharmaceutical Technology Co., Ltd 58
Shandong Suihua Biotechnology Co. Ltd 58
Henan Kaixin Biomedical Co., Ltd. 58
Shandong Suihua Biotechnology Co., Ltd. 58
Shanghai Boyle Chemical Co., Ltd. 55
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
3B Pharmachem (Wuhan) International Co.,Ltd. 69

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View Latest Price from 4-Chloro-3,5-dimethylphenol manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4-Chloro-3,5-dimethylphenol pictures 2026-09-18 4-Chloro-3,5-dimethylphenol
88-04-0
 1kg/bag ≥98% 50 T/Month Hebei Qujie Technology Co., Ltd.
4-Chloro-3,5-dimethylphenol/PCMX pictures 2026-09-18 4-Chloro-3,5-dimethylphenol/PCMX
88-04-0
 1kg 98.5%min 20 tons WUHAN FORTUNA CHEMICAL CO., LTD
4-Chloro-3,5-dimethylphenol pictures 2026-09-18 4-Chloro-3,5-dimethylphenol
88-04-0
 1KG 995 500mt Jinan Finer Chemical Co., Ltd

4-Chloro-3,5-dimethylphenol Spectrum

4-Chloro-3,5-dimethylphenol(88-04-0)MS4-Chloro-3,5-dimethylphenol(88-04-0)1HNMR4-Chloro-3,5-dimethylphenol(88-04-0)13CNMR4-Chloro-3,5-dimethylphenol(88-04-0)IR14-Chloro-3,5-dimethylphenol(88-04-0)IR24-Chloro-3,5-dimethylphenol(88-04-0)Raman

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Dettol, liquid antiseptic Dimethyl-4-chlorophenol Espadol Husept extra huseptextra Nipacide mx Nipacide PX nipacidemx Ottasept Ottasept extra ottaseptextra Parametaxylenol p-Chloro-3,5-xylenol p-chloro-m-xylenol-phenol Phenol, 4-chloro-3,5-dimethyl- Rba 777 rba777 Septiderm-hydrochloride Willenol V Xylenol, 4-chloro- P-CHLORO-M-XYLENOL 2-Chloro-m-xylenol 3,5-Xylenol, 4-chloro- 4-CHLORO-META-XYLENOL 4-CHLORO-3,5-XYLENOL 99+% 27) PARA CHLORO META XYLENOL 4-Chloro-3,5-diMethylphenol puruM, >=98.0% (T) Between the chlorine diMethyl phenol 4-Chloro-3.5-d 2,6-DiMethyl-4-hydroxy-1-chlorobenzene 4-Chloro-5,3-diMethylphenol 4 chloro 3,5 diMethylphenol p-Chloro-M-xylenol Chloro-3,5-diMethylp P-Chloro-M-Xylenol (PCMX), 4-Chloro-3,5-diMethylphenol Dett germicide 4-Chloro-3,5-dimethylphenol, 98+% 4-Chloro-3,5-dimethylphenol,99% 4-Chloro-3,5-dimethylphenol,4-Chloro-3,5-xylenol, 4-Chloro-sym-m-xylenol Chloroxylenol (125 mg) 4-Chloro-3,5-dimethy 4-Chloro-3,5-xylenol, 4-Chloro-sym-m-xylenol 4-Chloro-3,5-diMethylphenol, 99% 100GR Chloroxylenol/ PCMX/ 4-Chloro-3,5-dimethylphenol 1-[1-(benzenesulfonyl)-2-pyrrolyl]ethanone Ayrtol Benzytol Camel Chloro-3,5-dimethylphenol Chloro-3,5-xylenol Chloro-5-hydroxy-m-xylene Chloro-m-xylenol Chloroxylend Desson Dettol BENZYLTOL CHLORO-SYM-XYLENOL 3,5-DIMETHYL-4-CHLORO PHENOL 4-CHLORO-3,5-XYLENOL