1-Boc-1,7-diaminoheptane
- CAS No.
- 99733-18-3
- Chemical Name:
- 1-Boc-1,7-diaminoheptane
- Synonyms
- TERT-BUTYL 7-AMINOHEPTYLCARBAMATE;Boc-DAHpt;Boc-NH-(CH2)7-NH2;N-Boc-1,7-Diaminoheptane;1-Boc-1,7-diaminoheptane;N1-BOC-1,7-DIAMINOHEPTANE;N1-Boc-1,7-heptanediamine;tert-Butyl 2,8-diaminooctanoate;1,7-Diaminoheptane, N1-BOC protected;Heptane-1,7-diamine, N-Boc protected
- CBNumber:
- CB2672265
- Molecular Formula:
- C12H26N2O2
- Molecular Weight:
- 230.35
- MDL Number:
- MFCD02094498
- MOL File:
- 99733-18-3.mol
- MSDS File:
- SDS
| Melting point | 39-41 °C |
|---|---|
| Boiling point | 340.9±25.0 °C(Predicted) |
| Density | 0.949±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C(protect from light) |
| pka | 12.94±0.46(Predicted) |
| form | liquid |
| color | Colourless |
| InChI | 1S/C12H26N2O2/c1-12(2,3)16-11(15)14-10-8-6-4-5-7-9-13/h4-10,13H2,1-3H3,(H,14,15) |
| InChIKey | DTJYPERGUPPXRU-UHFFFAOYSA-N |
| SMILES | O=C(OC(C)(C)C)NCCCCCCCN |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H319-H335-H302+H312+H332-H315 |
| Precautionary statements | P261-P271-P280 |
| Hazard Codes | Xi |
| Hazard Note | Irritant |
| HS Code | 2921599090 |
1-Boc-1,7-diaminoheptane price More Price(45)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | OR1101 | Heptane-1,7-diamine, N-BOC protected 97% | 99733-18-3 | 100mg | $41 | 2026-06-04 | Buy |
| Apolloscientific | OR1101 | Heptane-1,7-diamine, N-BOC protected 97% | 99733-18-3 | 250mg | $73 | 2026-06-04 | Buy |
| Apolloscientific | OR1101 | Heptane-1,7-diamine, N-BOC protected 97% | 99733-18-3 | 1g | $209 | 2026-06-04 | Buy |
| Matrix Scientific | 306406 | tert-Butyl (7-aminoheptyl)carbamate | 99733-18-3 | 250.00mg | $62 | 2026-05-19 | Buy |
| Matrix Scientific | 306406 | tert-Butyl (7-aminoheptyl)carbamate | 99733-18-3 | 1.00g | $176 | 2026-05-19 | Buy |
1-Boc-1,7-diaminoheptane Chemical Properties, Uses, Production
Description
tert-Butyl (7-aminoheptyl)carbamate is an alkane chain with terminal amine and Boc-protected amino groups. The compound can be used as a PROTAC linker in the synthesis of PROTACs and other conjugation applications. Amine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The Boc group can be deprotected under mild acidic conditions to form the free amine.
Uses
tert-Butyl (7-aminoheptyl)carbamate (tert-Butyl 2,8-diaminooctanoate) is a PROTAC linker. tert-Butyl (7-aminoheptyl)carbamate can be used to synthesis CPD-10 (HY-168660)[1].
Synthesis
646-19-5
24424-99-5
99733-18-3
General procedure: preparation of mono-Boc-protected 1,7-diaminoheptane. Di-tert-butyl dicarbonate (Boc2O, 0.500 g, 2.291 mmol) was dissolved in chloroform (CHCl3, 10 mL) and the solution was added slowly and dropwise to a solution of 1,7-diaminoheptane (11.45 mmol) in chloroform (50 mL). The reaction mixture was stirred at room temperature for 24 hours. Subsequently, the reaction solution was concentrated and purified by fast column chromatography (silica gel, SiO2) using a gradient elution (0-10% MeOH) with chloroform/methanol (MeOH) containing 1% triethylamine (Et3N) to afford mono-Boc-protected 1,7-diaminoheptane ((tert-butyl (7-aminoheptyl)carbamate) as a colorless semi-solid (0.473 g, 90% yield ).1H NMR (CDCl3) δ: 4.52 (broad single peak, 1H), 3.12 (quadruple peak, J = 6.2 Hz, 2H), 2.70 (triple peak, J = 6.8 Hz, 2H), 1.43-1.23 (multiple peaks, 19H).
References
[1] Jing Liu, et al. Compounds and methods of treating cancers. French, WO2024183798A1.
1-Boc-1,7-diaminoheptane Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Beijing InnoChem Science & Technology Co., Ltd. | 15652467323 | sales@inno-chem.com.cn | China | 8390 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Shanghai Targsense Scientific Co., Ltd. | 18916626092 | targsense@qq.com | China | 110 | 65 |
| T&W GROUP | 021-61551611 13296011611 | contact@trustwe.com | China | 9884 | 58 |
| 9ding chemical ( Shanghai) Limited | 4009209199 | sales@9dingchem.com | China | 18201 | 56 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| BePharm Ltd | 400-685-9117 | market@bepharm.com | China | 15081 | 60 |
| MQ (shanghai) Pharmaceuticals Co., Ltd. | 13761635123 | sales@linyuepharm.com | China | 5731 | 55 |
| Amatek Scientific Co. Ltd. | 0512-56316828 400-867-5858;400-867-5858 | info@amateksci.com | China | 28760 | 58 |
| Jiaxing Deyi Chemical Co., Ltd. | 86-0573-85866609 18367600069 | 945717149@qq.com | China | 9506 | 58 |
View Latest Price from 1-Boc-1,7-diaminoheptane manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-08-30 | 1-BOC-1,7-DIAMINOHEPTANE
99733-18-3
|
$1.00 | 1KG | 95%-99% | 100KG | Career Henan Chemical Co |
-
- 1-BOC-1,7-DIAMINOHEPTANE
99733-18-3
- $1.00
- 95%-99%
- Career Henan Chemical Co
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