ChemicalBook >> CAS DataBase List >>4-Cyano-3-methylisoquinoline

4-Cyano-3-methylisoquinoline

4-Cyano-3-methylisoquinoline structure

CAS No.: 161468-32-2

Chemical Name:: 4-Cyano-3-methylisoquinoline

Synonyms: 4-Cyano-3-methylisoquinoline;4-Isoquinolinecarbonitrile, 3-methyl-

CBNumber:: CB2676157

Molecular Formula:: C11H8N2

Molecular Weight:: 168.19

MDL Number:: MFCD02179199

MOL File:: Mol file

MSDS File:: SDS

Last updated:2026-09-12 18:51:23

Request For Quotation

4-Cyano-3-methylisoquinoline Properties

Boiling point	330.9±22.0 °C(Predicted)
Density	1.17±0.1 g/cm3(Predicted)
storage temp.	2-8°C
solubility	Soluble in DMSO (50mg/ml)
form	solid
pka	2.26±0.31(Predicted)
color	white
InChI	1S/C11H8N2/c1-8-11(6-12)10-5-3-2-4-9(10)7-13-8/h2-5,7H,1H3
InChIKey	SZWLGBJCLZDZBY-UHFFFAOYSA-N
SMILES	n1cc2c(c(c1C)C#N)cccc2
UNSPSC Code	12352200
NACRES	NA.77

SAFETY

Risk and Safety Statements

WGK Germany	WGK 1
Storage Class	11 - Combustible Solids

4-Cyano-3-methylisoquinoline price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
aablocks	AA00AB6E	3-methyl-4-Isoquinolinecarbonitrile >95%	161468-32-2	1mg	$739	2026-05-28	Buy
AccelPharmtech	D4708	3-methyl-4-Isoquinolinecarbonitrile 97.00%	161468-32-2	1G	$2280	2026-05-21	Buy
AccelPharmtech	D4708	3-methyl-4-Isoquinolinecarbonitrile 97.00%	161468-32-2	5G	$3900	2026-05-21	Buy
AccelPharmtech	D4708	3-methyl-4-Isoquinolinecarbonitrile 97.00%	161468-32-2	25G	$7320	2026-05-21	Buy
American Custom Chemicals Corporation	PRK0000427	4-CYANO-3-METHYLISOQUINOLINE 95.00%	161468-32-2	5MG	$504.06	2021-12-16	Buy

Product number	Packaging	Price	Buy
AA00AB6E	1mg	$739	Buy
D4708	1G	$2280	Buy
D4708	5G	$3900	Buy
D4708	25G	$7320	Buy
PRK0000427	5MG	$504.06	Buy

4-Cyano-3-methylisoquinoline Chemical Properties, Uses, Production

Uses

4-Cyano-3-methylisoquinoline is an inhibitor for protein kinase A (PKA) with an IC50 of micromolar level. 4-Cyano-3-methylisoquinoline reverses morphine tolerance in mouse model[1].

Definition

ChEBI: 3-methyl-4-isoquinolinecarbonitrile is a member of isoquinolines.

Biological Activity

Cell permeable: yes', 'Primary Target
PKA', 'Product competes with ATP.', 'Reversible: yes', 'Target IC50: 30 nM against protein kinase A

storage

+4°C

References

[1] Smith FL, et al., The expression of a high level of morphine antinociceptive tolerance in mice involves both PKC and PKA. Brain Res. 2003 Sep 19;985(1):78-88. DOI:10.1016/s0006-8993(03)03170-6

4-Cyano-3-methylisoquinoline Preparation Products And Raw materials

Raw materials

Preparation Products

4-Cyano-3-methylisoquinoline Suppliers

Global Suppliers ( 17)

Supplier	Tel	Email	Country	ProdList	Advantage
VDM Biochemicals	0330-2528181	sales@vdmbio.com	United States	510	64
Henan Weitesi Chemical Technology Co. LTD	0371-55135753 18003832934	3842570495@qq.com	China	9993	58
Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd	043180534350 19917294565	et@chemextension.com	China	4445	58
TargetMol	400-821-0310 15002144251	xuexiang.shao@tsbiochem.com	China	29128	58
Shandong fusion Chemical Technology Co., Ltd.	13146841504	lifeng.cheng@strongerscience.com	China	5299	58
DAYANG CHEM (HANGZHOU) CO.,LTD	+86-88938639 +86-17705817739	info@dycnchem.com	China	53636	58
Jilin Chinese Academy of Sciences-yanshen Technology	18143011203	info@chemextension.com	China	42052	58

Supplier	Advantage
VDM Biochemicals	64
Henan Weitesi Chemical Technology Co. LTD	58
Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd	58
TargetMol	58
Shandong fusion Chemical Technology Co., Ltd.	58
DAYANG CHEM (HANGZHOU) CO.,LTD	58
Jilin Chinese Academy of Sciences-yanshen Technology	58

161468-32-2 (4-Cyano-3-methylisoquinoline) Related Search:

7-Bromo-4-methylisoquinoline 6-Chloro-3-methylisoquinoline 5-methylisoquinoline 3-Chloro-4-methylisoquinoline 7-bromo-6-methylisoquinoline

6-Bromo-3-methylisoquinoline 4-Amino-1-methylisoquinoline 5-Bromo-4-methylisoquinoline 6-fluoro-8-methylisoquinoline 1-Chloro-5-methylisoquinoline

1-Methylisoquinoline 5-bromo-8-methylisoquinoline 5-amino-6-methylisoquinoline 6-AMino-4-Methylisoquinoline 8-bromo-3-methylisoquinoline

3-Chloro-7-Methylisoquinoline 1,3-dimethylisoquinoline 7-fluoro-3-methylisoquinoline

1of4

4-Isoquinolinecarbonitrile, 3-methyl- 4-Cyano-3-methylisoquinoline 161468-32-2 A potent, cell-permeable, reversible, and specific inhibitor of protein kinase A.