1-(4-Chlorophenyl)-3-(4-methoxyphenyl)prop-2-en-1-one
- CAS No.
- 6552-63-2
- Chemical Name:
- 1-(4-Chlorophenyl)-3-(4-methoxyphenyl)prop-2-en-1-one
- Synonyms
- 4'-CHLORO-4-METHOXYCHALCONE;4'- chloro- 4- methoxy chalcone;1-(4-Chlorophenyl)-3-(4-methoxyphenyl)prop-2-en-1-one;2-Propen-1-one, 1-(4-chlorophenyl)-3-(4-methoxyphenyl)-
- CBNumber:
- CB2694043
- Molecular Formula:
- C16H13ClO2
- Molecular Weight:
- 272.73
- MDL Number:
- MFCD00018708
- MOL File:
- 6552-63-2.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
1-(4-Chlorophenyl)-3-(4-methoxyphenyl)prop-2-en-1-one price More Price(29)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | S547662 | 4'-CHLORO-4-METHOXYCHALCONE AldrichCPR | 6552-63-2 | 1 unit | $32.7 | 2026-04-30 | Buy |
| Sigma-Aldrich | S547662 | 4'-CHLORO-4-METHOXYCHALCONE Aldrich | 6552-63-2 | 250mg | $29.8 | 2024-03-01 | Buy |
| Biosynth | FC67418 | 4'-Chloro-4-methoxychalcone | 6552-63-2 | 10g | $150 | 2026-06-04 | Buy |
| Biosynth | FC67418 | 4'-Chloro-4-methoxychalcone | 6552-63-2 | 5g | $150 | 2026-06-04 | Buy |
| Biosynth | FC67418 | 4'-Chloro-4-methoxychalcone | 6552-63-2 | 25g | $272.5 | 2026-06-04 | Buy |
1-(4-Chlorophenyl)-3-(4-methoxyphenyl)prop-2-en-1-one Chemical Properties, Uses, Production
Synthesis
99-91-2
123-11-5
6552-63-2
The general procedure for the synthesis of 1-(4-chlorophenyl)-3-(4-methoxyphenyl)-2-propen-1-one from p-chloroacetophenone and p-methoxybenzaldehyde was as follows: a fresh sodium methanol/methanol solution was prepared by slicing sodium metal (0.01 g, 0.4 mmol) into thin slices and adding it slowly to anhydrous methanol (15 mL) in an ice bath until no more gas was produced. Subsequently, 4-methoxybenzaldehyde (1.36 g, 10.0 mmol) was added to the freshly prepared and cooled sodium methanol/methanol solution (15 mL), followed by the slow dropwise addition of 10.0 mmol of p-chloroacetophenone. The reaction mixture was stirred at room temperature for 2-8 hours (the reaction time was extended to 36-54 hours for substrates containing naphthalene groups or other large site-blocking groups). The reaction progress was monitored by thin layer chromatography (TLC). Upon completion of the reaction, water (20 mL) and ethyl acetate (75 mL in three additions of 25 mL each) were added to the mixture. The organic phase was separated and the aqueous phase was extracted three times with ethyl acetate. The organic phases were combined, washed three times with saturated brine and dried over anhydrous sodium sulfate. The crude product was purified by silica gel column chromatography using mixed solvent of ethyl acetate/hexane as eluent to give the pure α,β-unsaturated carbonyl compound (1-(4-chlorophenyl)-3-(4-methoxyphenyl)-2-propen-1-one).
References
[1] Bulletin of the Korean Chemical Society, 2016, vol. 37, # 2, p. 200 - 206
[2] Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1994, vol. 33, # 5, p. 455 - 459
[3] Synthetic Communications, 2010, vol. 40, # 19, p. 2887 - 2896
[4] Medicinal Chemistry Research, 2012, vol. 21, # 6, p. 922 - 931
[5] Natural Product Research, 2015, vol. 29, # 19, p. 1804 - 1810
1-(4-Chlorophenyl)-3-(4-methoxyphenyl)prop-2-en-1-one Preparation Products And Raw materials
Raw materials
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Preparation Products
1-(4-Chlorophenyl)-3-(4-methoxyphenyl)prop-2-en-1-one Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
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| T&W GROUP | 021-61551611 13296011611 | contact@trustwe.com | China | 9884 | 58 |
| Shanghai T&W Pharmaceutical Co., Ltd. | +86 21 61551611 | China | 9874 | 58 | |
| Shanghai Huikai Chemical Technology Co., Ltd. | 021-61995394 18916691159 | chemicalsea@163.com | China | 1970 | 58 |
| Shanghai HuanChuan Industry Co.,Ltd. | 021-61478794 | sales@hcshhai.com | China | 9781 | 50 |
| Credit Asia Chemical Co., Ltd. | +86 (21) 61124340 | China | 9739 | 58 | |
| Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 9778 | 55 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| SHANGHAI FDC-CHEMICAL CO.,LTD | 021-61469567 13774476675 | sales@fdc-chemical.com | China | 9999 | 58 |
| Rhawn Reagent | 400-400-1332688 18019345275 | huyue@rhawn.cn | China | 14942 | 58 |
| sgtlifesciences pvt ltd | +91-8790379245 | dj@sgtlifesciences.com | China | 12351 | 58 |
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