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Cytidine 5’-monophosphate

Cytidine 5’-monophosphate Structure
Cytidine 5’-monophosphate structure
CAS No.
63-37-6
Chemical Name:
Cytidine 5’-monophosphate
Synonyms
CMP;CYTIDYLIC ACID;5'-CMP;5'-CYTIDYLIC ACID;5'-CYTIDINE MONOPHOSPHATE;CYTIDINE-5'-MONOPHOSPHORIC ACID;((2R,3S,4R,5R)-5-(4-aMino-2-oxopyriMidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)Methyl dihydrogen phosphate;C-5-P;C-5'-P;CMP.H2
CBNumber:
CB2700845
Molecular Formula:
C9H14N3O8P
Molecular Weight:
323.2
MDL Number:
MFCD00006544
MOL File:
63-37-6.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-09-23 17:18:35
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Cytidine 5’-monophosphate Properties

Melting point ~222 °C (dec.)
Boiling point 678.1±65.0 °C(Predicted)
Density 2.15±0.1 g/cm3(Predicted)
refractive index 9.8 ° (C=1, 0.5mol/L Na2HPO4)
storage temp. 2-8°C
solubility Water (Slightly, Heated)
form crystalline
pka pK2:4.39(0);pK3:6.62(+1) (25°C)
color White
biological source synthetic
Water Solubility soluble
BRN 46982
InChI InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/t4-,6-,7-,8-/m1/s1
InChIKey IERHLVCPSMICTF-JDNPWWSISA-N
SMILES P(OC[C@H]1O[C@@H](N2C=CC(N)=NC2=O)[C@H](O)[C@@H]1O)(O)(O)=O
CAS DataBase Reference 63-37-6(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII F469818O25
EPA Substance Registry System 5'-Cytidylic acid (63-37-6)
UNSPSC Code 41116107
NACRES NA.51

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P305+P351+P338
PPE Eyeshields, Gloves, type N95 (US)
Hazard Codes  Xn,Xi
Risk Statements  20/21/22-36/37/38
Safety Statements  24/25-37/39-36-26
WGK Germany  3
RTECS  HA3980000
F  10-21
TSCA  TSCA listed
HS Code  29349990
Storage Class 11 - Combustible Solids
Toxicity LD50 intraperitoneal in mouse: > 1gm/kg
REACH Registrations Active
NFPA 704
0
1 0

Cytidine 5’-monophosphate price More Price(72)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich C1131 Cytidine 5′-monophosphate Sigma Grade, ≥99% (HPLC), synthetic, powder 63-37-6 1g $129 2026-04-30 Buy
Sigma-Aldrich 1162126 5′-Cytidylic acid United States Pharmacopeia (USP) Reference Standard 63-37-6 500mg $396 2026-04-30 Buy
TCI Chemical C1675 Cytidine 5'-Monophosphate >98.0%(HPLC) 63-37-6 1g $49 2026-04-30 Buy
TCI Chemical C1675 Cytidine 5'-Monophosphate >98.0%(HPLC) 63-37-6 5g $164 2026-04-30 Buy
Cayman Chemical 35116 Cytidine 5''-monophosphate ≥95% 63-37-6 1g $49 2026-04-30 Buy
Product number Packaging Price Buy
C1131 1g $129 Buy
1162126 500mg $396 Buy
C1675 1g $49 Buy
C1675 5g $164 Buy
35116 1g $49 Buy

Cytidine 5’-monophosphate Chemical Properties, Uses, Production

Description

Cytidine 5'-monophosphate, also known as 5'-CMP, is a nucleotide that is used as a monomer in RNA. 5'-CMP is a key intermediate in the preparation of several nucleotide derivatives and is widely used in food and pharmaceutical industries.

Chemical Properties

white crystalline powder

Uses

Cytidine 5′-monophosphate has been used in Raman spectroscopy studies.

Uses

Cytidine 5'-monophosphate (5'-CMP) is a key intermediate in the production of nucleotide derivatives and has been widely used in the food, agriculture and pharmaceutical industries.

Definition

ChEBI: Cytidine 5'-monophosphate is a pyrimidine ribonucleoside 5'-monophosphate having cytosine as the nucleobase. It has a role as a human metabolite, an Escherichia coli metabolite and a mouse metabolite. It is a pyrimidine ribonucleoside 5'-monophosphate and a cytidine 5'-phosphate. It is a conjugate acid of a cytidine 5'-monophosphate(2-).

Production Methods

As a key intermediate in preparing several nucleotide derivatives, cytidine 5′-monophosphate (5′-CMP) is widely applied in food and pharmaceutical industries. Enzymatic synthesis of 5′-CMP is catalyzed by cytidine kinase (CK, EC 2.7.1.213), a type of nucleoside kinase that belongs to the PfkB family. Li et al. constructed a highly efficient biosynthesis system for manufacturing 5′-CMP in vitro. CK was used for the biotransformation of cytidine to 5′-CMP, while polyphosphate kinase (PPK) was coupled for adenosine triphosphate regeneration. Both CK and PPK were selected from extremophiles, possessing great potential for biocatalytic synthesis. After optimization, 96 mM 5′-CMP was produced within 6 h, and the yield reached nearly 100%[1].

benefits

Cytidine 5’-monophosphate (CMP) is a nucleotide supplement with potential benefits such as improved muscle function, immune support, and enhanced neuronal growth. CMP is a component of RNA and phospholipids and sometimes pairs with uridine and other nutrients to produce synergistic effects, particularly in brain health. Studies have shown that adding CMP as a supplement to fish feed can contribute to their growth, health performance, and immune response.

Biochem/physiol Actions

Cytidine 5′-monophosphate (CMP) is used as a substrate of uridine monophosphate (UMP)/cytidine monophosphate (CMP) kinase (EC 2.7.4.4) to form CDP which upon phosphorylation to CTP supports DNA and RNA biosynthesis.

Side effects

Cytidine 5’-monophosphate (CMP) is a naturally occurring substance and is considered relatively safe, with no adverse health effects or respiratory irritation. No serious adverse reactions have been reported when CMP is used as a supplement; the most common side effects are gastrointestinal reactions, including nausea, vomiting, diarrhea, abdominal pain, and decreased appetite. Headaches may occur with long-term use.

References

[1] Zonglin Li. “Efficient One-Pot Synthesis of Cytidine 5′-Monophosphate Using an Extremophilic Enzyme Cascade System.” Journal of Agricultural and Food Chemistry 68 34 (2020): 9188–9194.

Cytidine 5’-monophosphate synthesis

3616-08-8
63-37-6
Synthesis of Cytidine 5’-monophosphate from CYTIDINE 3':5'-CYCLIC MONOPHOSPHATE

Cytidine 5’-monophosphate Preparation Products And Raw materials

Raw materials

Preparation Products

Polyinosinic acid-polycytidylic acid cytidine 5'-phosphate 2',3'-cyclic phosphate CYTIDINE 3'-MONOPHOSPHATE Citicoline sodium

Cytidine 5’-monophosphate Suppliers

Global Suppliers ( 732)
Supplier Tel Email Country ProdList Advantage
Jiangsu seed Chem Co., Ltd. 00-13862785 13862785735 1968341241@qq.com China 51 58
Anhui Chnbio Technology Co., Ltd. 18969017660 2424422732@qq.com China 103 58
Wuxi Jingyao Bio-Technology Co., Ltd. 88770633 13961738808 jingyaobiotech@126.com China 389 55
WeiTai BioPharmaceutical Co.,Ltd(Hangzhou?) 13282012786 13282132786 sales@weitai-pharmaceutical.com China 69 58
Zhengzhou convergence chemical co., LTD 037155153829 18003835034 3897192574@qq.com China 9985 58
Henan Forrest New Materials Technology Co., Ltd 18639096640 hnxxflst@163.com China 46 58
Yulin Runtianchang Chemical Co., Ltd 15890142075 15890142075 3555133855@qq.com China 9971 58
Xinxiang Yicheng Biotechnology Co.,LTD 0373-5799336 18937330588 xxycswsale@163.com China 71 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
Supplier Advantage
Jiangsu seed Chem Co., Ltd. 58
Anhui Chnbio Technology Co., Ltd. 58
Wuxi Jingyao Bio-Technology Co., Ltd. 55
WeiTai BioPharmaceutical Co.,Ltd(Hangzhou?) 58
Zhengzhou convergence chemical co., LTD 58
Henan Forrest New Materials Technology Co., Ltd 58
Yulin Runtianchang Chemical Co., Ltd 58
Xinxiang Yicheng Biotechnology Co.,LTD 58
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62

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Cytidine 5’-monophosphate Spectrum

Cytidine 5’-monophosphate(63-37-6)1HNMRCytidine 5’-monophosphate(63-37-6)13CNMRCytidine 5’-monophosphate(63-37-6)IR1

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C-5'-P C-5-P CMP MONOHYDRATE CYTIDINE-5'-MONOPHOSPHATE MONOHYDRATE 5'-CYTIDINE MONOPHOSPHATE 5'-CYTIDYLIC ACID MONOHYDRATE Cytidine Monophosphate and salts Cytidine 5'-monophate CYTIDINE 5'-MONOPHOSPHATE FREE ACIDSIGMA GRADE FRO Cmp:Cytidine-5'-MonophosphateFreeAcid CYTIDINE 5'-MONOPHOSPHATE, FREE ACID (5'-CMP) [5-(4-amino-2-oxo-pyrimidin-1-yl)-3,4-dihydroxy-oxolan-2-yl]methoxyphosphonic acid 5''-CYTIDINE MONOPHOSPHORIC ACID(FREE ACID) Cytidylic acid、CMP Cytidine-5''-monophosphoric acid (and/or unspecified salts) 5'-cytidylate monophosphate Cytidine 3'-(dihydrogen phosphate) 5-CYTIDYLICACID(5-CMP) Cytidine 5’-Monophosphate(CMP) CYTIDINE-5-MONOPHOSPHORIC ACID extrapure 5μ-CMP, 5μ-Cytidylic acid, C-5μ-P Cytidine mono(dihydrogen phosphate) Cytodine monophosphate: (Cytidine 5-monophosphate free acid) Cytidine-5'-monophosphoric acid hydrate,99% ((2R,3S,4R,5R)-5-(4-Amino-2-oxopyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl di 5'-CMP 5'-Cytidylic acid C-5'-P CMP 4-Amino-1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-5-yldihydrogenphosphate Cytidine -5'- Monophosphate（CMP-H） 5'-CMP(Cytidine 5'-monophosphate free acid) Cytidine-5'monophosphate(CMP),FREE ACID CMP.H2 cytidylic acid ,5'-cMp cytidine-5Monophophate cmp(nucleotide) cytidine5’-(dihydrogenphosphate) cytidine5’-phosphate cytidine5’-phosphoricacid cytidinemonophosphate ((2R,3S,4R,5R)-5-(4-aMino-2-oxopyriMidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)Methyl dihydrogen phosphate CYTIDINE-5'-MONOPHOSPHATE(P) ((2R,3S,4R,5R)-5-(4-Amino-2-oxopyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihyd 5'-CMPH2 5'-Cytidylic Acid (500 mg) 5 ' - Cyticline Monophosphoric Acid (Free Acid ) 4-aMino-1-(O5-phosphono-pentofuranosyl)-1H-pyriMidin-2-one Cytidylic acid SynonyMs 5'-cytidylate Monophosphate Cytidine 5'-monophosphate (5'-CMP) Cytidine 5′-monophosphate, synthetic, 99% Cytidine 5'-Monophosphate > Cytidylic acid Solution, 100μg/mL -cytidylate monophosphate 5'-CYTIDYLATE MONOPHOSPHATE（CMP） Cytidylic acid USP/EP/BP CYTIDINE-5'-MONOPH0SPHATE 5'-Cytidine monophosphate free acid ((2R,3S,4R,5R)-5-(4-Amino-2-oxopyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrog Cytidine-5-Monophosphate (5-CMP) extrapure, 99% 5''-Cytidylic Acid (1162126)