DODAP
- CAS No.
- 127512-29-2
- Chemical Name:
- DODAP
- Synonyms
- DODAP;18:1 DAP;DODAP (18:1);1,2-DIOLEOYL-3-DIMETHYLAMMONIUM-PROPANE;1,2-DIOLEOYLOXY-3-(DIMETHYLAMINO)PROPANE;3-(dimethylamino)propane-1,2-diyl dioleate;(Z)-3-(Dimethylamino)propane-1,2-diyl dioleate;1,2-dioleoyl-3-dimethylammonium-propane (DODAP);1,2-dioleoxy-3- (dimethylamino) propane (DODAP);1,2-dioleoyloxy-3- (dimethylamino) propane (DODAP)
- CBNumber:
- CB2703992
- Molecular Formula:
- C41H77NO4
- Molecular Weight:
- 648.05
- MDL Number:
- MFCD01321074
- MOL File:
- 127512-29-2.mol
- MSDS File:
- SDS
| Boiling point | 670.1±55.0 °C(Predicted) |
|---|---|
| Density | 0.916±0.06 g/cm3(Predicted) |
| storage temp. | -20°C Freezer, Under Inert Atmosphere |
| solubility | Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly) |
| form | Oil |
| pka | 8.02±0.28(Predicted) |
| color | Colourless to Light Yellow |
| Stability | Light Sensitive; Hydroscopic; Store at -15 to -25°C |
| InChIKey | NYDLOCKCVISJKK-WRBBJXAJSA-N |
| SMILES | C(OC(=O)CCCCCCC/C=C\CCCCCCCC)(CN(C)C)COC(=O)CCCCCCC/C=C\CCCCCCCC |
| UNSPSC Code | 12352211 |
| NACRES | NA.25 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS06,GHS08 |
|---|---|
| Signal word | Danger |
| Hazard statements | H302-H315-H319-H331-H336-H351-H361d-H372 |
| Precautionary statements | P202-P301+P312-P302+P352-P304+P340+P311-P305+P351+P338-P308+P313 |
DODAP price More Price(14)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | D6266 | 3-(Dimethylamino)propane-1,2-diyl Dioleate | 127512-29-2 | 50MG | $194 | 2025-07-31 | Buy |
| TCI Chemical | D6266 | 3-(Dimethylamino)propane-1,2-diyl Dioleate | 127512-29-2 | 200MG | $483 | 2025-07-31 | Buy |
| Cayman Chemical | 25726 | 1,2-Dioleoyl-3-dimethylammonium-propane ≥98% | 127512-29-2 | 5mg | $33 | 2024-03-01 | Buy |
| Cayman Chemical | 25726 | 1,2-Dioleoyl-3-dimethylammonium-propane ≥98% | 127512-29-2 | 10mg | $62 | 2024-03-01 | Buy |
| Cayman Chemical | 25726 | 1,2-Dioleoyl-3-dimethylammonium-propane ≥98% | 127512-29-2 | 50mg | $190 | 2024-03-01 | Buy |
DODAP Chemical Properties,Uses,Production
Description
DODAP (18:1) is an ionizable cationic lipid with lower cytotoxicity and high transfection efficiency. DODAP is neutral at physiological pH, but acquires a positive charge inside the endosome due to the protonation of free amines when pH is lower than its pKa (<7).
Chemical Properties
Light Yellow Oil
Uses
DODAP is a cationic lipid utilized as the lipid component in liposomes (pKa = 5.59 in TNS binding tests). DODAP is employed for encapsulating siRNA and delivering immunostimulated chemotherapeutic agents both in vitro and in vivo. DODAP holds great promise for research in vaccines and inflammation[1][2][3][4][5].
in vivo
In vitro potency of DODAP (100 μg/mL, i.v., i.m., 4h) strongly predicts in vivo potency for intramuscular administration but not for intravascular administration in female Balb/c mice[1].
| Animal Model: | female Balb/c mice[1] |
| Dosage: | 100 μg/mL |
| Administration: | Intravenous injection (i.v.), Intramuscular injection (i.m.),4 h |
| Result: | Treatment resulted that a less negatively charged DODAP was more efficient in vitro and in vivo intramuscular injection, while for Intravenous injection administration, a more negative DODAP that was passively targeted through Apo-E absorption was more efficient for hepatocyte targeting. |
References
[1] Carrasco MJ, et al. Ionization and structural properties of mRNA lipid nanoparticles influence expression in intramuscular and intravascular administration. Commun Biol. 2021 Aug 11;4(1):956. DOI:10.1038/s42003-021-02441-2
[2] Dabbas S, et al. Importance of the liposomal cationic lipid content and type in tumor vascular targeting: physicochemical characterization and in vitro studies using human primary and transformed endothelial cells. Endothelium. 2008;15(4):189-201. DOI:10.1080/10623320802228583
[3] Hamzah J, et al. Targeted liposomal delivery of TLR9 ligands activates spontaneous antitumor immunity in an autochthonous cancer model. J Immunol. 2009;183(2):1091-1098. DOI:10.4049/jimmunol.0900736
[4] Liu Q, et al. Biotinylated cyclen-contained cationic lipids as non-viral gene delivery vectors. Chem Biol Drug Des. 2013;82(4):376-383. DOI:10.1111/cbdd.12159
[5] Mendon?a LS, et al. Transferrin receptor-targeted liposomes encapsulating anti-BCR-ABL siRNA or asODN for chronic myeloid leukemia treatment. Bioconjug Chem. 2010 Jan;21(1):157-68. DOI:10.1021/bc9004365
DODAP Preparation Products And Raw materials
Raw materials
Preparation Products
DODAP Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19552 | 58 |
| XIAMEN SINOPEG BIOTECH CO., LTD. | +86-0592-7761068 +8617350879715 | changaiwei@sinopeg.com | China | 411 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615531151365 | mina@chuanghaibio.com | China | 18126 | 58 |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 8497 | 58 |
| Zhengzhou Alfa Chemical Co.,Ltd | +8618530059196 | sale04@alfachem.cn | China | 12177 | 58 |
| Baoji Guokang Bio-Technology Co., Ltd. | 0917-3909592 13892490616 | gksales1@gk-bio.com | China | 9235 | 58 |
| Nanjing Doge Biomedical Technology Co., Ltd | +86-25-58227606 +86-15305155328 | sales@dogechemical.com | China | 4128 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49734 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39031 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 | market18@leapchem.com | China | 43339 | 58 |
View Lastest Price from DODAP manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-09-16 | DODAP
127512-29-2
|
US $37.00-58.00 / mg | 98.70% | 10g | TargetMol Chemicals Inc. | ||
 |
2025-09-10 | DODAP
127512-29-2
|
US $0.00-0.00 / g | 1g | 98% | 1g/bottle , 10g/bottle, 100g/bottle | XIAMEN SINOPEG BIOTECH CO., LTD. | |
 |
2025-06-27 | DODAP
127512-29-2
|
US $0.00-0.00 / KG | 1KG | 99% | 500000kg | Hebei Chuanghai Biotechnology Co., Ltd |
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