Ozagrel
- CAS No.
- 82571-53-7
- Chemical Name:
- Ozagrel
- Synonyms
- Ozagre;Xanbon;OKY-046;OZAGREL;Cataclot;Ozagrel API;Ozagrel, ≥98%;Mr Zardari gray;Ozagrel(OKY-046);OzagrelSodium99%
- CBNumber:
- CB2734655
- Molecular Formula:
- C13H12N2O2
- Molecular Weight:
- 228.25
- MDL Number:
- MFCD00868231
- MOL File:
- 82571-53-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 223-224° |
|---|---|
| Boiling point | 468.0±25.0 °C(Predicted) |
| Density | 1.17±0.1 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | DMSO : 50 mg/mL (219.06 mM; Need ultrasonic) |
| form | Powder |
| pka | 4.43±0.10(Predicted) |
| color | White to off-white |
| CAS DataBase Reference | 82571-53-7(CAS DataBase Reference) |
| FDA UNII | L256JB984D |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P264-P270-P301+P312-P330-P501 | |||||||||
| NFPA 704 |
|
Ozagrel price More Price(51)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | O0610 | Ozagrel | 82571-53-7 | 1G | $71 | 2026-04-30 | Buy |
| TCI Chemical | O0610 | Ozagrel | 82571-53-7 | 5G | $214 | 2026-04-30 | Buy |
| Cayman Chemical | 70515 | Ozagrel ≥98% | 82571-53-7 | 5mg | $38 | 2026-04-30 | Buy |
| Cayman Chemical | 70515 | Ozagrel ≥98% | 82571-53-7 | 10mg | $71 | 2026-04-30 | Buy |
| Cayman Chemical | 70515 | Ozagrel ≥98% | 82571-53-7 | 50mg | $291 | 2026-04-30 | Buy |
Ozagrel Chemical Properties, Uses, Production
Platelet aggregation inhibitor
Ozagrel and clopidogrel, cilostazol, aspirin enteric-coated tablets are commonly used in China at present as platelet aggregation inhibitor, Ozagrel is an anti-thrombosis drug which belongs to a thromboxane alkyl cyclooxygenase (TXA2) inhibitors, originally it was successfully developed by Japan Ono pharmaceutical Co., Ltd. and Kissei pharmaceutical Co., Ltd. ,it was approved for marketing in Japan in 1988. At present, domestic manufacturers include the Liaoning dandong, medical and pharmaceutical industry, Shandong Elohim Pharmaceutical Co., Changchun fine distinctions Pharmaceutical, Dalian Metro big pharmaceutical companies, pharmaceutical Shenyang Jishi, Hainan bikai Pharmaceutical, Changchun Haobang Pharmaceutical and Shandong HuaLu pharmaceutical. Modern medicine has proved that platelets play an important role in the process of atherosclerosis and thrombosis, the effective regulation of platelet can play a multiplier effect on blood vessel lumen stenosis, emboli and diseases caused by occlusion of blood circulatory system . At present, the platelet aggregation inhibitor drugs used clinically are mainly cyclooxygenase (TXA2) inhibitors, phosphodiesterase (PDE) inhibitors, adenosine diphosphate (ADP) receptor antagonists, platelet fibrinogen antagonists drugs.
Ozagrel sodium salt has a strong antithrombotic effect, which is the world's first listing inhibitor of the potent thromboxane synthase feature ,it has the inhibiting effect on the platelet aggregation induced by different inducers (such as collagen, arachidonic acid, epinephrine, ADP, 5-HT, etc.) ,it can inhibit TXA2 synthase, while it can promot the generation of PGI2, it has effect on anti-platelet aggregation and relieving the vasospasm, it can inhibit the cerebral thrombosis and cerebral vasospasm. It is Mainly applied to the improvement of subarachnoid hemorrhage after cerebral vasospasm and cerebral ischemic symptoms. It can reduce cerebral infarction fibrin, and factor I,it can reduce blood viscosity and inhibit platelet aggregation.in the cerebral embolism model tests caused by the injection of arachidonic acid , after taking the product ,the occurrence of cerebral thrombosis is suppressed , animal mortality is decreased, while not only the cerebral movement disorders of acute phase is improved , but also the circulatory disorders of the acute phase of cerebral ischemia are improved,and the energy metabolism of cerebral ischemia is improved. Common agents are ozagrel injection, each 20mg.it is diluted by physiological saline or glucose injection then intravenous infusion, every day 80mg. when it is combined with other anti-platelet drugs, the dose of this product should be reduced. There may be bleeding tendency; occasional allergy, liver dysfunction, blood pressure drops, the outdoor contraction, headache, injection site pain, abdominal distension and other adverse reactions. Hemorrhage patients (intracerebral hemorrhage, intraventricular hemorrhage, gastrointestinal bleeding, subcutaneous bleeding, etc.), pregnant women or potentially pregnant women and children should use with caution. And it has a synergistic effect with drugs having inhibition of platelet function ,when they are used together, there must be appropriate reduction. Avoid mixing injection with calcium solution (Green solution, etc.) in order to avoid opacification.
The above information is edited by the Chemicalbook of Tian Ye.
Chemical Properties
Obtain prismatic crystals From ethanol-diethyl ether , melting point 223~224 ℃.
Hydrochloric acid Ozagrel (Ozagrel Hydrochloride): C13H12N2O2 HCl. [78712-43-3]. crystallization From ethanol-ethyl ether , melting point 214~217 ℃.
Ozadrel Sodium: C13 H11N2NaO2. White crystal or crystalline powder, odorless, Pickle bitter. Soluble in water, soluble in methanol, insoluble in ethanol, acetone or ether. Acute toxicity LD50 male and female mice, male and female rats (mg/kg): 1940,1580,1150,1300 intravenous injection; 3800.3600.5900,5700 oral; 2450,2100,2300,2250 subcutaneous injection.
Uses
Strong thromboxane synthetase inhibitors. By inhibiting thromboxane synthase,it reduces the body thromboxane A, (TXA2), and promotes prostacyclin (PGl2) generation to be against aggregation of platelets, and cerebrovascular spasm, and it almost has no effect on cyclooxygenase and other arachidonic metabolizing enzymes.it is Clinically used for improving cerebral vasospasm after cobweb inferior vena hemorrhage surgery and symptoms of cerebral ischemia associated with cerebral vasospasm, and dyskinesia associated with cerebral thrombosis acute phase.
production method
Use dehydrated methyl benzaldehyde as materials,after condensation with acetic anhydride aldol ,form 3-tolyl acrylate, become into a 3--tolyl acrylate ethyl after esterification , use benzoyl peroxide as an initiator, with N-bromosuccinimide (NBS) ,make the methyl on the ring become into bromomethyl, and after the hydrolysis reaction with imidazole, ozagrel sodium is obtained , melting point 308 ℃ (decomposition).
Description
Ozagrel sodium is the first thromboxane (TX2) synthetase inhibitor to be developed as an antithrombotic agent. In patients with angina pectoris, ozagrel sodium reportedly decreases the frequency of anginal attacks and increases exercise tolerance. Other indications for ozagrel sodium currently under study include bronchial asthma and pulmonary thromboembolism.
Originator
Ono (Japan)
Uses
Ozagrel is a potent and selective thromboxane A2 inhibitor. Used in the prevention of ischemic stroke injury and maintains a strong effect in vascular contraction and vascular endothelial cell dysfunction.
Definition
ChEBI: Ozagrel is a member of cinnamic acids.
brand name
Xanbon; Cataclot
References
[1] Patent: CN106380448, 2017, A. Location in patent: Paragraph 0046; 0047; 0048; 0049; 0050; 0051; 0052; 0053
Ozagrel Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Chembest Research Laboratories Limited | 021-20908456 | sales@BioChemBest.com | China | 5996 | 61 |
| ShangHai DEMO Chemical Co.,Ltd | 400-021-7337 2355568890 | sales@demochem.com | China | 2569 | 57 |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| Wuhan Wei Shunda Technology Development Co., Ltd. | 86-027-88774375 | mwmwhot@163.com | China | 233 | 65 |
| LGM Pharma | 1-(800)-881-8210 | inquiries@lgmpharma.com | United States | 2110 | 70 |
| Shanghai Longsheng chemical Co.,Ltd. | 58099637 13585536065 | sales@shlschem.com | China | 9880 | 59 |
| XiaoGan ShenYuan ChemPharm co,ltd | 15527621225; 15527621225 | 1791901229@qq.com | China | 6741 | 52 |
| Shanghai Ennopharm Co., Ltd. | +86 (21) 6435-5022 | China | 4263 | 65 | |
| Jinan Chenghui Shuangda biological Co., LTD | 053158897070 15550412551 | market@jnchsd.com | China | 224 | 62 |
View Latest Price from Ozagrel manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-17 | Ozagrel
82571-53-7
|
1KG | 99%min; CP | 100kg | WUHAN FORTUNA CHEMICAL CO., LTD | ||
 |
2026-08-20 | Ozagrel USP/EP/BP
82571-53-7
|
$1.10 | 1g | 99.9% | 100 Tons min | Dideu Industries Group Limited | |
 |
2026-07-14 | Ozagrel
82571-53-7
|
$39.00-108.00 | 97.90% | 10g | TargetMol Chemicals Inc. |
-
- Ozagrel
82571-53-7
- $0.00
- 99%min; CP
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- Ozagrel USP/EP/BP
82571-53-7
- $1.10
- 99.9%
- Dideu Industries Group Limited
-
- Ozagrel
82571-53-7
- $39.00-108.00
- 97.90%
- TargetMol Chemicals Inc.
