Agnuside
- CAS No.
- 11027-63-7
- Chemical Name:
- Agnuside
- Synonyms
- Vitex Oil;Agnusid;Agnoside;AGNUSIDE;Oyster oil;AGNUSIDE(P);Buddlejoside A;chasteberry oil;Agnuside (25 mg);AGNUSIDE WITH HPLC
- CBNumber:
- CB2737818
- Molecular Formula:
- C22H26O11
- Molecular Weight:
- 466.44
- MDL Number:
- MFCD21333314
- MOL File:
- 11027-63-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 146℃ |
|---|---|
| Boiling point | 785.5±60.0 °C(Predicted) |
| Density | 1.59±0.1 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | DMSO, Methanol |
| pka | 8.14±0.15(Predicted) |
| form | Solid |
| color | Yellow |
| optical activity | [α]/D -98.0±5°, c = 0.1 in ethanol |
| BRN | 4925795 |
| Major Application |
metabolomics vitamins, nutraceuticals, and natural products |
| InChIKey | GLACGTLACKLUJX-QNAXTHAFSA-N |
| SMILES | [C@]12([H])C(COC(=O)C3=CC=C(O)C=C3)=C[C@H](O)[C@@]1([H])C=CO[C@@H]2O[C@H]1[C@H](O)[C@H]([C@H](O)[C@@H](CO)O1)O |&1:0,15,17,22,24,25,27,28,30,r| |
| LogP | -1.240 (est) |
| FDA UNII | JB24Q0OT9G |
| UNSPSC Code | 85151701 |
| NACRES | NA.25 |
Agnuside price More Price(57)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | PHL89155 | Agnuside phyproof? Reference Substance | 11027-63-7 | 10mg | $473 | 2026-04-30 | Buy |
| Sigma-Aldrich | 1012203 | Agnuside United States Pharmacopeia (USP) Reference Standard | 11027-63-7 | 25mg | $1330 | 2026-04-30 | Buy |
| Sigma-Aldrich | 12274 | Agnuside analytical standard | 11027-63-7 | 10mg | $511.8 | 2024-03-01 | Buy |
| Cayman Chemical | 24971 | Agnuside ≥98% | 11027-63-7 | 1mg | $54 | 2026-04-30 | Buy |
| Cayman Chemical | 24971 | Agnuside ≥98% | 11027-63-7 | 5mg | $172 | 2026-04-30 | Buy |
Agnuside Chemical Properties, Uses, Production
Chemical Properties
Yellow Oil
Uses
Agnuside is an known iridoid glycoside found in Vitex herbs or plants. Agnuside have been used in various applications including in the treatment of premenstrual syndrome and regulation of menopause s ymptoms. This is mainly due to the fact that Agnuside exhibits estrogen-like activities as it interacts with estrogen receptors (ER-alpha) and estrogen receptor-regulated pregesterone receptors. Recen t studies have also evaluated Agnuside for the probable mechanism of anti-arthritic activity, which suggested the possible development of Agnuside as a therapeutic agent in the treatment of arthritis by the modulation of the host immune response.
Definition
ChEBI: Agnuside is a benzoate ester resulting from the formal condensation of the carboxy group of 4-hydroxybenzoic acid with the primary hydroxy group of aucubin. It is an iridoid glycoside found in several Vitex plants including Vitex agnus-castus. It has a role as a plant metabolite, an anti-inflammatory agent, a pro-angiogenic agent and a cyclooxygenase 2 inhibitor. It is a terpene glycoside, an iridoid monoterpenoid, a benzoate ester, a member of phenols, a beta-D-glucoside, a cyclopentapyran and a monosaccharide derivative. It is functionally related to an aucubin.
benefits
Agnuside is one of the most significant active ingredients in chasteberry and is described chemically as an ester of p-hydroxybenzoic acid and aucubin. Agnuside’s greatest areas of benefit involve female reproductive cycles, which researchers believe is due to its effect on the pituitary gland. One study has also shown that extracts of chasteberry fruit bind to the opiate receptors in the brain, which would explain its use in relieving discomfort.
in vivo
Agnuside (6.25 mg/kg; Oral administration; Single dose) reduces the levels of allergic inflammatory mediators in a dose-dependent manner and can inhibit allergic inflammation in Balb/C mice[1]. Agnuside (6.25 mg/kg; Oral administration; Single dose) can inhibit autophagy in allergic asthma in Balb/C mice [1]. Agnuside (6.25 mg/kg; Oral administration; single dose) can reduce synovitis and fibrosis in knee osteoarthritis (KOA) in MIA-induced KOA mice[4].
| Animal Model: | Balb/C female mice model [1] |
| Dosage: | 30 mg/kg, 60 mg/kg |
| Administration: | Oral gavage (p.o.); Single dose; |
| Result: | Decreased the expression of LC3B and increased the expression of Beclin1/p62 (LC3B and Beclin1/p62 are autophagy markers). Decreased the levels of IgE and IL-4/ IL-10 in a dose-dependent manner.( IgE and IL-4/ IL-10 are allergic inflammatory mediators) |
| Animal Model: | KAO rat model[4] |
| Dosage: | 6.25 mg Monosodium iodoacetate (MIA): 1 mg |
| Administration: | Oral gavage (p.o.); Single dose |
| Result: | Alleviated the degree of local hypoxia in the synovial tissue of rats and significantly reduced the level of pro-fibrotic substances in the synovial tissue. Inhibited the accumulation of HIF-1α and activation of NLRP3 inflammasome. |
IC 50
EP
Agnuside Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Chengdu Biopurify Ltd. | 82633860 18982077548 | cwb1@biopurify.cn | China | 4630 | 58 |
| Hubei Danding Pharmaceutical Technology Co., Ltd | 17701422019 17701422019 | 181646821@qq.com | China | 2421 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| Shandong Xiya Chemical Co., Ltd | 13355009207 13355009207 | 3007715519@qq.com | China | 18722 | 57 |
| Sinopharm Chemical Reagent Co,Ltd. | 86-21-63210123 | sj_scrc@sinopharm.com | China | 9791 | 79 |
| Maya High Purity Chemicals | +86 (573) 82222445 (0)18006601000 452520369 | sales@maya-r.com | China | 11693 | 57 |
| BioBioPha Co., Ltd. | 0871-65217109 | y.liu@mail.biobiopha.com | China | 5641 | 65 |
| Chengdu Biopurify Phytochemicals Ltd. | +86-028-82633397 18982077548 | cwb1@biopurify.cn | China | 2376 | 60 |
| Chengdu Climax Biotech Co., Ltd. | 028-83311324 1278112614 | climaxbiotech@gmail.com | China | 925 | 58 |
Related articles
- Agnuside: Natural Iridoid Glycoside
- Agnuside is a traditional medicinal iridoid glycoside that alleviates knee osteoarthritis synovitis and fibrosis via targeted ....
- May 8,2026
View Latest Price from Agnuside manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-27 | Agnuside
11027-63-7
|
$39.00-148.00 | 99.08% | 10g | TargetMol Chemicals Inc. | ||
 |
2025-06-20 | Agnuside
11027-63-7
|
$25.00-100.00 | 1kgkg | 0.99 | 100 | Hebei Yanxi Chemical Co., Ltd. | |
 |
2025-03-10 | Agnuside
11027-63-7
|
$10.00-30.00 | 50KG | 99% | 500000kg | Hebei Chuanghai Biotechnology Co., Ltd |
