4-Nitro-isatoic anhydride
- CAS No.
- 63480-10-4
- Chemical Name:
- 4-Nitro-isatoic anhydride
- Synonyms
- NSC 135175;4-Nitro-isatoic anhydride;4-Nitroisatoicanhydride97%;4-Nitroisatoic anhydride 97%;7-nitro-1H-3,1-benzoxazine-2,4-dion;7-nitro-1H-3,1-benzoxazine-2,4-dione;7-Nitro-2H-3,1-benzoxazine-2,4(1H)-dione;7-NITRO-1H-BENZO[D][1,3]OXAZINE-2,4-DIONE;2H-3,1-Benzoxazine-2,4(1H)-dione, 7-nitro-;7-nitro-2H-benzo[d][1,3]oxazine-2,4(1H)-dione
- CBNumber:
- CB2744890
- Molecular Formula:
- C8H4N2O5
- Molecular Weight:
- 208.13
- MDL Number:
- MFCD00798220
- MOL File:
- 63480-10-4.mol
- MSDS File:
- SDS
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
|---|---|
| form | wooly crystalline powder |
| color | Lemon |
| CAS DataBase Reference | 63480-10-4(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| HS Code | 2934999090 |
4-Nitro-isatoic anhydride price More Price(59)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| AstaTech | 69441 | 4-NITRO-ISATOIC ANHYDRIDE 98% | 63480-10-4 | 5G | $23 | 2026-04-30 | Buy |
| AstaTech | 69441 | 4-NITRO-ISATOIC ANHYDRIDE 98% | 63480-10-4 | 25G | $129 | 2026-04-30 | Buy |
| AstaTech | 69441 | 4-NITRO-ISATOIC ANHYDRIDE 98% | 63480-10-4 | 100G | $447 | 2026-04-30 | Buy |
| Apolloscientific | OR400019 | 4-Nitroisatoic anhydride 95% | 63480-10-4 | 1g | $21 | 2026-06-04 | Buy |
| Apolloscientific | OR400019 | 4-Nitroisatoic anhydride 95% | 63480-10-4 | 5g | $28 | 2026-06-04 | Buy |
4-Nitro-isatoic anhydride Chemical Properties, Uses, Production
Synthesis
32315-10-9
619-17-0
63480-10-4
The general procedure for the synthesis of 7-nitro-1H-benzo[d][1,3]oxazine-2,4-dione from tritiated gas and 2-amino-4-nitrobenzoic acid was as follows: to a 500 mL single-necked round-bottomed flask equipped with a soccer ball shaped PTFE stirring bar (16 mm × 37 mm) was added 2-amino-4-nitrobenzoic acid (10.0 g, 46.3 mmol, 1.0 eq. ), followed by tetrahydrofuran (230 mL, 0.2 M) and solid triphosgene (13.7 g, 46.3 mmol, 1.0 eq.) to form a suspension. The reaction flask was placed in a device equipped with a metal heating jacket with a 24/40 Liebig condenser attached to the neck of the flask. The suspension was stirred at 500 rpm and the temperature of the heating jacket was set to 70°C. After about 30 minutes, the suspension became homogeneous and subsequently precipitated a white solid. The non-homogeneous reaction mixture was allowed to stand for 12 hours and then cooled to room temperature (25°C). The reaction slurry was poured into a 600 mL beaker equipped with an overhead mechanical stirrer (PTFE 75 mm paddle) and 250 mL of deionized water was added. Under vigorous stirring, the mixture first became homogeneous and then precipitated as a pale white solid. The solids were collected by vacuum filtration through a Brinell funnel (7.6 cm diameter, lined with Whatman 1 filter paper, 70 mm) and purged with air for 5 min. The resulting solids were transferred to a 250 mL conical flask, 50 mL of methanol was added, and the slurry was stirred using a cylindrical rod for 10 min, after which the solids were again collected by vacuum filtration. The filter cake was dried under vacuum (0.1 mmHg, 25 °C) for 12 h. The final product was 7-nitro-1H-benzo[d][1,3]oxazine-2,4-dione as a white powder in 90% yield.
References
[1] Beilstein Journal of Organic Chemistry, 2018, vol. 14, p. 2529 - 2536
[2] European Journal of Medicinal Chemistry, 1994, vol. 29, # 12, p. 925 - 940
[3] Patent: EP1719771, 2006, A1. Location in patent: Page/Page column 51
[4] Journal of Agricultural and Food Chemistry, 2015, vol. 63, # 31, p. 6883 - 6889
4-Nitro-isatoic anhydride Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Shanghai Sinch Parmaceuticals Tech. Co. Ltd. | +86-21-54098501 | sales@sinch.com.cn | China | 11592 | 64 |
| China DongFan Chemical Co.,LTD | 86-0571-85151182 | China | 5681 | 66 | |
| Chengdu HappySyn Pharmaceutical Technology Co., Ltd. | 85114309 18982182443 | yangli@happysyn.com | China | 2297 | 55 |
| Shanghai Yolne Chemical Co., Ltd. | 021-62960152 | 934678158@qq.com | China | 9886 | 55 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Shanghai Balmxy Pharmaceutical Co., Ltd | 021-24206007 13764915196 | sales@balmxy.com | China | 6959 | 55 |
| Cool Pharm, Ltd | 021-60455363 18019463053 | sales@coolpharm.com | China | 8455 | 58 |
| Struchem Co., Ltd. | 0512-63009836 18994340901 | helen@struchem.com | China | 3970 | 60 |
View Latest Price from 4-Nitro-isatoic anhydride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-01-08 | 4-NITRO-ISATOIC ANHYDRIDE
63480-10-4
|
$1.00 | 1KG | 99.0% | 100kg | Career Henan Chemical Co |
-
- 4-NITRO-ISATOIC ANHYDRIDE
63480-10-4
- $1.00
- 99.0%
- Career Henan Chemical Co
