Thevetiaflavone
- CAS No.
- 29376-68-9
- Chemical Name:
- Thevetiaflavone
- Synonyms
- Thevetiaflavone;5-O-METHYLAPIGENIN;Apigenin 5-methylether;Apigenin 5-O-monomethyl ether;4',7-Dihydroxy-5-methoxyflavone;Flavone,4',7-dihydroxy-5-methoxy- (8CI);Apigenin-5-methyl ether,5-0-Methylapigenin;7-Hydroxy-2-(4-hydroxyphenyl)-5-methoxy-4H-chromen-4-one;4H-1-Benzopyran-4-one,7-hydroxy-2-(4-hydroxyphenyl)-5-methoxy-;ethylprop-2-enoate,2-methylprop-2-enoicacid,propane-1,2-diol,styrene
- CBNumber:
- CB2748959
- Molecular Formula:
- C16H12O5
- Molecular Weight:
- 284.26
- MDL Number:
- MFCD02683421
- MOL File:
- Mol file
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
Thevetiaflavone price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 583008 | Thevetiaflavone ≥98% | 29376-68-9 | 5mg | $792 | 2026-06-03 | Buy |
| Biosynth | FT139054 | Thevetiaflavone | 29376-68-9 | 1mg | $392.65 | 2026-06-04 | Buy |
| Biosynth | FT139054 | Thevetiaflavone | 29376-68-9 | 2mg | $691.06 | 2026-06-04 | Buy |
| Biosynth | FT139054 | Thevetiaflavone | 29376-68-9 | 5mg | $1492.05 | 2026-06-04 | Buy |
| Biosynth | FT139054 | Thevetiaflavone | 29376-68-9 | 10mg | $2827 | 2026-06-04 | Buy |
Thevetiaflavone Chemical Properties, Uses, Production
Uses
Thevetiaflavone inhibited the secretion of β-glucuronidase from neutrophils in rabbits, ED50 was 20μM. And it inhibited sarcoplasmic reticulum Ca2+-ATPase, when the concentration was 100μM, the inhibition rate was 69 %.
Preparation
The method for obtaining a refined extract from capers, comprising the following steps: a) making the concentrated capers crude extract go up to macroporous adsorption resin chromatography, and eluting with water and ethanol solution; b) eluting with ethanol solution , that is, the refined extract of capers.
Biological Activity
Thevetiaflavone can up-regulate the expression of Bcl-2 and down-regulate the expression of Bax and caspase-3.
in vivo
Thevetiaflavone, a natural flavonoid obtained from Wikstroemia indica, could improve cell viability and suppresses the leakage of lactate dehydrogenase from the cytoplasm. Further investigation of the mechanisms demonstrated that it decreases overproduction of ROS and ameliorates ROSmediated mitochondrial dysfunction , including collapse of mitochondrial membrane potential and mitochondrial permeability transition pore opening. It reduces the intracellular Ca 2+ level, which is closely associated with mitochondrial function and interplays with ROS. Furthermore, Thevetiaflavone inhibits apoptosis in PC12 cells through upregulating the expression of Bcl2 and downregulating that of Bax and caspase3 in addition to increasing the activity of caspase3. These results further indicate the protective effects of the vetiaflavone in vivo and its application in the clinic.
IC 50
Bcl-2; Bax; Caspase-3
Thevetiaflavone Preparation Products And Raw materials
Raw materials
Preparation Products
Thevetiaflavone Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BioBioPha Co., Ltd. | 0871-65217109 | y.liu@mail.biobiopha.com | China | 5641 | 65 |
| Shanghai Winherb Medical Technology Co., Ltd. | 17301719108 13341702378 | winherb@126.com | China | 1245 | 58 |
| Wuxi Zhongkun Biochemical Technology Co., Ltd. | 0510-85629785 18013409632; | sales@reading-chemicals.com | China | 15165 | 58 |
| Wuhan ChemFaces Biochemical Co., Ltd. | 18607101326 15172504745 | aileen@chemfaces.com | China | 6904 | 55 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8435 | 60 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Chengdu Push Bio-Technology Co., Ltd. | 028-85370565-229 18080489829 | 18080489829@163.com | China | 8379 | 60 |
| Nanjing Digger Medical Technology Co. Ltd. | 025-025-51191215 18013836722 | 2399235533@qq.com | China | 4932 | 58 |
| Fan De(Beijing) Biotechnology Co., Ltd. | 15911056312 | liming@bio-fount.com | China | 9718 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
