Purine riboside-5'-O-triphosphate sodium salt
- CAS No.
- 23197-96-8
- Chemical Name:
- Purine riboside-5'-O-triphosphate sodium salt
- Synonyms
- PuTP;PUTP SODIUM SALT;Purine riboside triphosphate;Purine riboside-5'-triphosphate;Purine riboside-5'-O-triphosphate sodium salt;purineriboside-5’-o-triphosphate(putp),sodiumsalt;1-purin-9-yl-O5-(tetrahydroxy-[1]triphosphoryl)-β-D-1-deoxy-ribofuranose
- CBNumber:
- CB2770826
- Molecular Formula:
- C10H11N4Na4O13P3
- Molecular Weight:
- 580.09
- MDL Number:
- MFCD04118066
- MOL File:
- 23197-96-8.mol
- MSDS File:
- SDS
Purine riboside-5'-O-triphosphate sodium salt Chemical Properties, Uses, Production
Uses
Purine riboside-5'-O-triphosphate, an active metabolite of Nebularine (HY-103694), acts as an inhibitor of DNA primase ATP and GTP polymerization activities, with IC50 values of 35 μM and 28 μM for the human enzyme, respectively. Purine riboside-5'-O-triphosphate also inhibits calmodulin-dependent protein kinase II (CaMKII) with a Ki value of 590 μM[1][2][3].
References
[1] Kozlowska M, et al. ATP depletion, purine riboside triphosphate accumulation and rat thymocyte death induced by purine riboside. Toxicol Lett. 1999;104(3):171-181. DOI:10.1016/s0378-4274(98)00369-5
[2] Moore CL, et al. Human DNA primase uses Watson-Crick hydrogen bonds to distinguish between correct and incorrect nucleoside triphosphates. Biochemistry. 2004;43(38):12367-12374. DOI:10.1021/bi0490791
[3] Kwiatkowski AP, et al. Mapping of the adenosine 5'-triphosphate binding site of type II calmodulin-dependent protein kinase. Biochemistry. 1987;26(24):7636-7640. DOI:10.1021/bi00398a016
Purine riboside-5'-O-triphosphate sodium salt Preparation Products And Raw materials
Raw materials
Preparation Products
Purine riboside-5'-O-triphosphate sodium salt Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| NewCan Biotech Limited | +86-571-86912261 19975279805 | sales@newcanbio.com | China | 9984 | 58 |
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| Shanghai meikai technology co., ltd | 021-68689288 15300790979 | info@mkbio.com.cn | China | 9988 | 58 |
| Supplier | Advantage |
|---|---|
| NewCan Biotech Limited | 58 |
| BOC Sciences | 58 |
| Changsha Morning Shine Co., Ltd. | 58 |
| Shanghai meikai technology co., ltd | 58 |




