Hydroxyzine dihydrochloride
- CAS No.
- 2192-20-3
- Chemical Name:
- Hydroxyzine dihydrochloride
- Synonyms
- orgatrax;Hydroxyzine 2HCl;QYS;Quies;Disron;Durrax;Quiess;alamon;neurolax;(S)-Hydroxyzine
- CBNumber:
- CB2777401
- Molecular Formula:
- C21H29Cl3N2O2
- Molecular Weight:
- 447.83
- MDL Number:
- MFCD00058200
- MOL File:
- 2192-20-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 190-192°C |
|---|---|
| Flash point | 9℃ |
| storage temp. | 2-8°C |
| solubility | H2O: soluble |
| form | powder |
| color | White to Off-White |
| Water Solubility |
H2O: soluble alcohol: soluble chloroform: soluble |
| InChI | 1S/C21H27ClN2O2.2ClH/c22-20-8-6-19(7-9-20)21(18-4-2-1-3-5-18)24-12-10-23(11-13-24)14-16-26-17-15-25;;/h1-9,21,25H,10-17H2;2*1H |
| InChIKey | ANOMHKZSQFYSBR-UHFFFAOYSA-N |
| SMILES | Cl[H].Cl[H].OCCOCCN1CCN(CC1)C(c2ccccc2)c3ccc(Cl)cc3 |
| CAS DataBase Reference | 2192-20-3(CAS DataBase Reference) |
| FDA UNII | 76755771U3 |
| EPA Substance Registry System | Ethanol, 2-[2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]-, dihydrochloride (2192-20-3) |
| UNSPSC Code | 41116107 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H336-H361d |
| Precautionary statements | P202-P261-P264-P270-P301+P312-P308+P313 |
| target organs | Central nervous system |
| PPE | dust mask type N95 (US), Eyeshields, Gloves |
| Hazard Codes | Xn |
| Risk Statements | 22-36/37/38 |
| Safety Statements | 26 |
| WGK Germany | 3 |
| RTECS | KK2280000 |
| TSCA | TSCA listed |
| HS Code | 29335990 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Acute Tox. 4 Oral Repr. 2 STOT SE 3 |
| Toxicity | LD50 in rats (mg/kg): 126 i.p.; 950 orally (Goldenthal) |
| REACH Registrations | Active |
Hydroxyzine dihydrochloride price More Price(51)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | H1435000 | Hydroxyzine hydrochloride European Pharmacopoeia (EP) Reference Standard | 2192-20-3 | 600 mg | $167 | 2026-04-30 | Buy |
| Sigma-Aldrich | H-124 | Hydroxyzine dihydrochloride solution 1.0?mg/mL in methanol (as free base), ampule of 1?mL, certified reference material, Cerilliant? | 2192-20-3 | 1mL | $136 | 2026-04-30 | Buy |
| Sigma-Aldrich | BP841 | Hydroxyzine hydrochloride British Pharmacopoeia (BP) Reference Standard | 2192-20-3 | 100 mg | $251 | 2026-04-30 | Buy |
| Sigma-Aldrich | 1333003 | Hydroxyzine hydrochloride United States Pharmacopeia (USP) Reference Standard | 2192-20-3 | 500mg | $455 | 2026-04-30 | Buy |
| TCI Chemical | H1832 | Hydroxyzine Dihydrochloride | 2192-20-3 | 1G | $26 | 2026-04-30 | Buy |
Hydroxyzine dihydrochloride Chemical Properties,Uses,Production
Chemical Properties
White Solid
Originator
Atarax,UCB,France,1956
Uses
H1 receptor antagonist. Anxiolytic. Antihistaminic.
Uses
Antihistaminic;H1 antogonist
Uses
Anti histamines
Uses
Hydroxyzine dihydrochloride has been used in the study of comparative anxiolytic activity of various drugs in experimental models of rats.
Manufacturing Process
A mixture of 0.1 mol of N-mono-1-p-chlorobenzohydrylpiperazine and 0.1 mol
of 1-chloro-2-(2-hydroxy-ethoxy)-ethane is heated for 3 hours to 150°C. The
mass is then taken up in 100 ml of benzene and 100 ml of a 10% aqueous
solution of NaOH; decanting takes place, and the benzene solution is washed
with water and the solvent is evaporated. Vacuum distilling of the residue
yields 1-p-chlorobenzohydryl-4-[2-(2-hydroxy-ethoxy)-ethyl]-piperazine, BP
220°C/0.5 mm Hg.
The corresponding dihydrochloride is prepared by dissolving this base in about
twice its weight of alcohol, by treating it with excess of gaseous HCl and by
precipitating it with ether. The solvent is decanted and the residue, dissolved
in a minimum of alcohol, crystallizes on the addition of ether, MP 193°C.
brand name
Amplimexon (Amplimed).
Therapeutic Function
Tranquilizer
General Description
Hydroxyzine dihydrochloride is an antihistaminic drug and a member of the diphenylmethanes family. It exerts its action by blocking the action of histamine, a substance in the body that causes allergic symptoms.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Biochem/physiol Actions
Hydroxyzine dihydrochloride (HDH) is used to regulate anxiety. It is also used to treat bronchial asthma and to relax patients before surgery.
Hydroxyzine dihydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
| LGM Pharma | 1-(800)-881-8210 | inquiries@lgmpharma.com | United States | 2110 | 70 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| Sinopharm Chemical Reagent Co,Ltd. | 86-21-63210123 | sj_scrc@sinopharm.com | China | 9791 | 79 |
| Maya High Purity Chemicals | +86 (573) 82222445 (0)18006601000 452520369 | sales@maya-r.com | China | 11693 | 57 |
| ZhengZhou HuaWen Chemical Co.Ltd | 0370-2785118 17550508557 | 675141927@qq.com | China | 3201 | 55 |
| Spectrum Chemical Manufacturing Corp. | 021-021-021-67601398-809-809-809 15221380277 | marketing_china@spectrumchemical.com | China | 9643 | 60 |
| Wuhan Fortuna Chemical Co., Ltd | 027-59207852 13308628970 | buy@fortunachem.com | China | 2698 | 58 |
View Lastest Price from Hydroxyzine dihydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-20 | Hydroxyzine dihydrochloride USP/EP/BP
2192-20-3
|
$1.10 | 1g | 99.9% | 100 Tons min | Dideu Industries Group Limited | |
 |
2026-08-12 | Hydroxyzine dihydrochloride
2192-20-3
|
$1910.00 | 20KG | 99% | 10T | Baoji Guokang Healthchem Co., Ltd. | |
 |
2026-06-30 | Hydroxyzine dihydrochloride
2192-20-3
|
1kg | 99% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd |
-
- Hydroxyzine dihydrochloride USP/EP/BP
2192-20-3
- $1.10
- 99.9%
- Dideu Industries Group Limited
-
- Hydroxyzine dihydrochloride
2192-20-3
- $1910.00
- 99%
- Baoji Guokang Healthchem Co., Ltd.
-
- Hydroxyzine dihydrochloride
2192-20-3
- $0.00
- 99%
- Shaanxi Dideu New Materials Co. Ltd
