Sonelokimab
- CAS No.
- 1414386-05-2
- Chemical Name:
- Sonelokimab
- Synonyms
- Sonelokimab;Research Grade Sonelokimab;Research Grade Sonelokimab(DHH28808)
- CBNumber:
- CB28081191
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- Mol file
- MSDS File:
- SDS
- TDS File:
- TDS
| form | Liquid |
|---|---|
| color | Colorless to light yellow |
| FDA UNII | LEN0OCZ4SH |
Sonelokimab price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0624046 | Sonelokimab 99.81% | 1414386-05-2 | 1mg | $704 | 2026-06-04 | Buy |
| ChemScene | CS-0624046 | Sonelokimab 99.81% | 1414386-05-2 | 5mg | $1842 | 2026-06-04 | Buy |
| ChemScene | CS-0624046 | Sonelokimab 99.81% | 1414386-05-2 | 10mg | $2925 | 2026-06-04 | Buy |
| aablocks | AA029Z53 | Sonelokimab >98% | 1414386-05-2 | 1mg | $758 | 2026-06-02 | Buy |
| aablocks | AA029Z53 | Sonelokimab >98% | 1414386-05-2 | 5mg | $1924 | 2026-06-02 | Buy |
Sonelokimab Chemical Properties, Uses, Production
Uses
Sonelokimab (ALX 0761) is a trivalent bispecific nanobody composed of camel derived humanized IL-17F antibodies, IL-17A/F antibodies, and serum albumin VHH antibodies. Sonelokimab can prolong the plasma half-life by binding to human serum albumin. Sonelokimab can be used for research on rheumatoid arthritis and psoriasis[1][2][3][4].
in vivo
Sonelokimab (2.8 and 10 mg/kg, s.c., weekly intervals for 8 consecutive weeks) reduces IL-15, IL-6, MMP-3 and TNF-α expression and demonstrates the potential preventive effect of arthritis in a collagen-induced arthritis model in cynomolgus monkey[4].
| Animal Model: | A collagen-induced arthritis model in cynomolgus monkey[4] |
| Dosage: | 2.8 and 10 mg/kg |
| Administration: | weekly intervals for 8 consecutive weeks |
| Result: | Significantly improved X-ray score B and the arthritis score in a collagen-induced arthritis model in cynomolgus monkey. |
IC 50
IL-17A; IL-17F
References
[1] Torres T, et al. A revolutionary therapeutic approach for psoriasis: bispecific biological agents. Expert Opin Investig Drugs. 2016 Jul;25(7):751-4. DOI:10.1080/13543784.2016.1187130
[2] Rossotti MA, et al. Immunogenicity and humanization of single-domain antibodies. FEBS J. 2022 Jul;289(14):4304-4327. DOI:10.1111/febs.15809
[3] Gao W, et al. Comparation of time-course, dose-effect, influencing factors and adverse events of biologics in the treatment of adults with moderate to severe plaque psoriasis. Front Immunol. 2023 May 25;14:1151977. DOI:10.3389/fimmu.2023.1151977
[4] Vanheusden K, et al. Pre-clinical proof-of-concept of ALX-0761, a Nanobody neutralizing both IL-17A and F in a cynomolgus monkey collagen induced arthritis model[C]//ARTHRITIS AND RHEUMATISM. 111 RIVER ST, HOBOKEN 07030-5774, NJ USA: Wiley-Blackwell, 2013, 65: S543-S543.
Sonelokimab Preparation Products And Raw materials
Raw materials
Preparation Products
Sonelokimab Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ShangHai Biochempartner Co.,Ltd | 177-54423994 17754423994 | 2853530910@QQ.com | China | 8000 | 62 |
| Wuhan Chemstan Biotechnology Co., Ltd. | 027-65317797 15926423062 | 422450190@qq.com | China | 10305 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 | psaitong@jm-bio.com | China | 27626 | 58 |
| Biolab Reagents | 027-65279366 18108604356 | products@biolabreagent.com | China | 9864 | 58 |
| Wuhan Jingkangen Biomedical Technology Co., Ltd | 13720134139 086-15871494362 13720134139 | orders@jknbiochem.com | China | 7283 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11963 | 58 |
| Atagenix Laboratories | 027-87008169 17762441161 | info@atagenix.com | China | 9997 | 58 |
| Wuhan Maixi Biotechnology Co., Ltd | 18007167883 18007167883 | Service@mabnus.com | China | 921 | 58 |
| TargetMol | 400-821-0310 15002144251 | xuexiang.shao@tsbiochem.com | China | 29128 | 58 |
| Shanghai Fengyong Biotechnology Co., Ltd. | 021-10000000 13000000000 | gzj@abmole.cn | China | 9323 | 58 |
