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INDEX NAME NOT YET ASSIGNED

INDEX NAME NOT YET ASSIGNED Structure
INDEX NAME NOT YET ASSIGNED structure
CAS No.
2413035-41-1
Chemical Name:
INDEX NAME NOT YET ASSIGNED
Synonyms
SJF 0628;(2S,4R)-1-((S)-2-(2-(4-(4-(3-(2,6-Difluoro-3-(propylsulfonamido)benzoyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)phenyl)piperazin-1-yl)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide;(2S，4R)-1-[(2S)-2-{2-[4-(4-{3-[2,6-difluoro-3-(propane-1-sulfonamido)Benzoyl]-1Hpyrrolo[2,3-b]pyridin-5-yl}phenyl)piperazin-1-yl]acetamido}-3,3-dimethylbutanoyl]-4-hydroxy-N-{[4-(4-methyl-1,3-thiazole-5-yl)pyrrolidin-2-carboxylic acid amide
CBNumber:
CB28201069
Molecular Formula:
C51H57F2N9O7S2
Molecular Weight:
1010.19
MDL Number:
MOL File:
2413035-41-1.mol
Last updated:2025-04-18 09:51:56
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INDEX NAME NOT YET ASSIGNED Properties

Density 1.368±0.06 g/cm3(Predicted)
solubility DMSO:101.02(Max Conc. mg/mL);100.0(Max Conc. mM)
form Solid
pka 6.29±0.10(Predicted)
color Off-white to light yellow

INDEX NAME NOT YET ASSIGNED Chemical Properties,Uses,Production

Uses

SJF-0628 (compound 512) is a PROTAC RAF degrader. SJF-0628 induces targeted degradation of BRAF mutants (DC50: 5.4 nM, 4.64 nM, 15.5 nM, 2.11 nM, 63.9 nM for BRAF V600E, V600K, G464V, G469A, K601E respectively). SJF-0628 has anti-tumor activity. SJF-0628 can be used for research of disorders that result from aggregation or accumulation of RAF, or the constitutive activation of RAF[1].

storage

Store at -20°C

References

[1] Andrew P. Crew, et al. Compounds and methods for the targeted degradation of rapidly accelerated fibrosarcoma polypeptides. Patent. US 20200129627 A1.
[2] Chapdelaine AG, et al. The Targeted Degradation of BRAF V600E Reveals the Mechanisms of Resistance to BRAF-Targeted Treatments in Colorectal Cancer Cells. Cancers (Basel). 2023 Dec 12;15(24):5805. DOI:10.3390/cancers15245805

INDEX NAME NOT YET ASSIGNED Preparation Products And Raw materials

Raw materials

Preparation Products

INDEX NAME NOT YET ASSIGNED Suppliers

Global( 3)Suppliers
Supplier Tel Email Country ProdList Advantage
Nanjing Chemlin Chemical Co., Ltd 025-83697070 info@chemlin.com.cn China 19274 64
R&D Systems, Inc 18003437475 18003437475 rdname@qq.com China 6960 58
Cayman Chemical Company 800-364-9897 sales@caymanchem.com China 6838 58
Supplier Advantage
Nanjing Chemlin Chemical Co., Ltd 64
R&D Systems, Inc 58
Cayman Chemical Company 58
(2S，4R)-1-[(2S)-2-{2-[4-(4-{3-[2,6-difluoro-3-(propane-1-sulfonamido)Benzoyl]-1Hpyrrolo[2,3-b]pyridin-5-yl}phenyl)piperazin-1-yl]acetamido}-3,3-dimethylbutanoyl]-4-hydroxy-N-{[4-(4-methyl-1,3-thiazole-5-yl)pyrrolidin-2-carboxylic acid amide (2S,4R)-1-((S)-2-(2-(4-(4-(3-(2,6-Difluoro-3-(propylsulfonamido)benzoyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)phenyl)piperazin-1-yl)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide SJF 0628 2413035-41-1 C51H57F2N9O7S2