| Company Name: |
Nanjing Chemlin Chemical Co., Ltd
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| Tel: |
025-83697070 |
| Email: |
info@chemlin.com.cn |
| Products Intro: |
Product Name:(2S，4R)-1-[(2S)-2-{2-[4-(4-{3-[2,6-Difluoro-3-(propane-1-sulfonamido)benzoyl]-1hpyrrolo[2,3-b]pyridin-5-yl}phenyl)piperazin-1-yl]acetamido}-3,3-dimethylbutanoyl]-4-hydroxy-N-{[4-(4-methyl-1,3-thiazole-5-yl)pyrrolidin-2-carboxylic acid amide
CAS:2413035-41-1
Purity:98% Package:5KG; 1KG
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| Company Name: |
R&D Systems, Inc
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| Tel: |
18003437475 18003437475 |
| Email: |
rdname@qq.com |
| Products Intro: |
Product Name:SJF 0628
CAS:2413035-41-1
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| Company Name: |
Cayman Chemical Company
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| Tel: |
800-364-9897 |
| Email: |
sales@caymanchem.com |
| Products Intro: |
Product Name:PROTAC RAF Degrader 1
CAS:2413035-41-1
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| | INDEX NAME NOT YET ASSIGNED Basic information |
| Product Name: | INDEX NAME NOT YET ASSIGNED | | Synonyms: | (2S，4R)-1-[(2S)-2-{2-[4-(4-{3-[2,6-difluoro-3-(propane-1-sulfonamido)Benzoyl]-1Hpyrrolo[2,3-b]pyridin-5-yl}phenyl)piperazin-1-yl]acetamido}-3,3-dimethylbutanoyl]-4-hydroxy-N-{[4-(4-methyl-1,3-thiazole-5-yl)pyrrolidin-2-carboxylic acid amide;(2S,4R)-1-((S)-2-(2-(4-(4-(3-(2,6-Difluoro-3-(propylsulfonamido)benzoyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)phenyl)piperazin-1-yl)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide;SJF 0628 | | CAS: | 2413035-41-1 | | MF: | C51H57F2N9O7S2 | | MW: | 1010.19 | | EINECS: | | | Product Categories: | | | Mol File: | 2413035-41-1.mol |  |
| | INDEX NAME NOT YET ASSIGNED Chemical Properties |
| density | 1.368±0.06 g/cm3(Predicted) | | solubility | DMSO:101.02(Max Conc. mg/mL);100.0(Max Conc. mM) | | form | Solid | | pka | 6.29±0.10(Predicted) | | color | Off-white to light yellow |
| | INDEX NAME NOT YET ASSIGNED Usage And Synthesis |
| Uses | SJF-0628 (compound 512) is a PROTAC RAF degrader. SJF-0628 induces targeted degradation of BRAF mutants (DC50: 5.4 nM, 4.64 nM, 15.5 nM, 2.11 nM, 63.9 nM for BRAF V600E, V600K, G464V, G469A, K601E respectively). SJF-0628 has anti-tumor activity. SJF-0628 can be used for research of disorders that result from aggregation or accumulation of RAF, or the constitutive activation of RAF[1]. | | storage | Store at -20°C | | References | [1] Andrew P. Crew, et al. Compounds and methods for the targeted degradation of rapidly accelerated fibrosarcoma polypeptides. Patent. US 20200129627 A1.
[2] Chapdelaine AG, et al. The Targeted Degradation of BRAF V600E Reveals the Mechanisms of Resistance to BRAF-Targeted Treatments in Colorectal Cancer Cells. Cancers (Basel). 2023 Dec 12;15(24):5805. DOI:10.3390/cancers15245805 |
| | INDEX NAME NOT YET ASSIGNED Preparation Products And Raw materials |
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