ChemicalBook >> CAS DataBase List >>Benzo[c][1,3]benzodioxolo[5,6-h][1,6]naphthyridin-13(12H)-one, 12-[2-(dimethylamino)ethyl]-2,3-dimethoxy-

Benzo[c][1,3]benzodioxolo[5,6-h][1,6]naphthyridin-13(12H)-one, 12-[2-(dimethylamino)ethyl]-2,3-dimethoxy-

Benzo[c][1,3]benzodioxolo[5,6-h][1,6]naphthyridin-13(12H)-one, 12-[2-(dimethylamino)ethyl]-2,3-dimethoxy- structure

CAS No.: 500214-53-9

Chemical Name:: Benzo[c][1,3]benzodioxolo[5,6-h][1,6]naphthyridin-13(12H)-one, 12-[2-(dimethylamino)ethyl]-2,3-dimethoxy-

Synonyms: Topoval;ARC-111;Topovale;Benzo[c][1,3]benzodioxolo[5,6-h][1,6]naphthyridin-13(12H)-one, 12-[2-(dimethylamino)ethyl]-2,3-dimethoxy-

CBNumber:: CB28383602

Molecular Formula:: C23H23N3O5

Molecular Weight:: 421.45

MDL Number:: MFCD08056235

MOL File:: 500214-53-9.mol

MSDS File:: SDS

Last updated:2025-09-22 14:50:28

Request For Quotation

Benzo[c][1,3]benzodioxolo[5,6-h][1,6]naphthyridin-13(12H)-one, 12-[2-(dimethylamino)ethyl]-2,3-dimethoxy- Properties

Melting point	229-232 °C
Boiling point	648.8±55.0 °C(Predicted)
Density	1.325±0.06 g/cm3(Predicted)
pka	8.86±0.28(Predicted)
FDA UNII	7GL8K930U6

Benzo[c][1,3]benzodioxolo[5,6-h][1,6]naphthyridin-13(12H)-one, 12-[2-(dimethylamino)ethyl]-2,3-dimethoxy- Chemical Properties,Uses,Production

Uses

Topovale (ARC 111) is a topoisomerase I inhbitor. Topovale is an antitumor agent, and shows low nM cytotoxicity against a panel of cancer cells. Topovale induces reversible topoisomerase I (TOP1) cleavage complexes in tumor cells[1].

IC 50

Topoisomerase I

References

[1] Li TK, et al. Characterization of ARC-111 as a novel topoisomerase I-targeting anticancer drug. Cancer Res. 2003 Dec 1;63(23):8400-7. PMID:14679002

Benzo[c][1,3]benzodioxolo[5,6-h][1,6]naphthyridin-13(12H)-one, 12-[2-(dimethylamino)ethyl]-2,3-dimethoxy- Preparation Products And Raw materials

Raw materials

Preparation Products

Benzo[c][1,3]benzodioxolo[5,6-h][1,6]naphthyridin-13(12H)-one, 12-[2-(dimethylamino)ethyl]-2,3-dimethoxy- Suppliers

Global( 17)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
TargetMol Chemicals Inc.	+1-781-999-5354; +17819995354	marketing@targetmol.com	United States	32432	58
TargetMol Chemicals Inc.	+1-781-999-5354;	support@targetmol.com	United States	39031	58
Shanghai YuanYe Biotechnology Co., Ltd.	021-61312847; 18021002903	3008007409@qq.com	China	71826	60
Shanghai Chaolan Chemical Technology Center	021-QQ：65489617 15618227136	Sales@ATKchemical.com	China	9848	58
Shochem(Shanghai)Co.,Ltd	+86-021-51783479 +86-13816874662	info@shochem.com	China	307	58
TargetMol Chemicals Inc.	4008200310	marketing@tsbiochem.com	China	24989	58
Shanghai Yifei Biotechnology Co. , Ltd.	021-65675885 18964387627	customer_service@efebio.com	China	11973	58
Yantai Shengkailun Chemical Technology Co., Ltd.	13356901049	mark@sklnchem.cn	China	9818	58
Jiangsu Aikon Biopharmaceutical R&D Co.,Ltd	025-58851090 17714375163	2881759498@qq.com	China	13011	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
TargetMol Chemicals Inc.	58
TargetMol Chemicals Inc.	58
Shanghai YuanYe Biotechnology Co., Ltd.	60
Shanghai Chaolan Chemical Technology Center	58
Shochem(Shanghai)Co.,Ltd	58
TargetMol Chemicals Inc.	58
Shanghai Yifei Biotechnology Co. , Ltd.	58
Yantai Shengkailun Chemical Technology Co., Ltd.	58
Jiangsu Aikon Biopharmaceutical R&D Co.,Ltd	58

View Lastest Price from Benzo[c][1,3]benzodioxolo[5,6-h][1,6]naphthyridin-13(12H)-one, 12-[2-(dimethylamino)ethyl]-2,3-dimethoxy- manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2025-09-22	Topovale 500214-53-9	US $88.00-255.00 / mg		99.94%	10g	TargetMol Chemicals Inc.

Topovale
500214-53-9
US $88.00-255.00 / mg
99.94%
TargetMol Chemicals Inc.

Benzo[c][1,3]benzodioxolo[5,6-h][1,6]naphthyridin-13(12H)-one, 12-[2-(dimethylamino)ethyl]-2,3-dimethoxy- ARC-111 Topoval Topovale 500214-53-9