Nylidrin
- CAS No.
- 447-41-6
- Chemical Name:
- Nylidrin
- Synonyms
- buphenine;Buphenin;Nylidrin;Nylidrine;DILATAL(NYLIDRIN;Nylidrin USP/EP/BP;4-(1-Hydroxy-2-((4-phenylbutan-2-yl)amino)propyl)phenol;1-(4-hydroxyphenyl)-2-(1-methyl-3-phenylpropylamino)propan-1-ol;4-Hydroxy-α-[1-(1-methyl-3-phenylpropylamino)ethyl]benzyl alcohol;1-(4-Hydroxyphenyl)-2-[(1-methyl-3-phenylpropyl)amino]-1-propanol
- CBNumber:
- CB2875325
- Molecular Formula:
- C19H25NO2
- Molecular Weight:
- 299.4073
- MDL Number:
- MFCD00599550
- MOL File:
- 447-41-6.mol
- MSDS File:
- SDS
| Melting point | 111-112° |
|---|---|
| Boiling point | 476.0±40.0 °C(Predicted) |
| Density | 1.101±0.06 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2) (1:7): 0.12 mg/ml |
| form | A crystalline solid |
| pka | 9.96±0.26(Predicted) |
| FDA UNII | 695DKH33EI |
| ATC code | C04AA02,G02CA02 |
SAFETY
Risk and Safety Statements
| Hazardous Substances Data | 447-41-6(Hazardous Substances Data) |
|---|
Nylidrin price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 33232 | Nylidrin ≥85% | 447-41-6 | 5mg | $36 | 2026-04-30 | Buy |
| Cayman Chemical | 33232 | Nylidrin ≥85% | 447-41-6 | 10mg | $63 | 2026-04-30 | Buy |
| Cayman Chemical | 33232 | Nylidrin ≥85% | 447-41-6 | 25mg | $128 | 2026-04-30 | Buy |
| Cayman Chemical | 33232 | Nylidrin ≥85% | 447-41-6 | 50mg | $219 | 2026-04-30 | Buy |
| ChemScene | CS-0085441 | Nylidrin | 447-41-6 | 5mg | $32 | 2026-06-04 | Buy |
Nylidrin Chemical Properties, Uses, Production
Originator
Arlidin,U.S.V. ,US,1955
Uses
Buphenin (Nylidrin), is shown to be an effective inhibitor of IgE-mediated release of histamine from human basophils, and thus can be used as antiallergic agent. It is also one of the FDA approved drug as Inhibitors of the Human Sodium Taurocholate Cotransporting Polypeptide (NTCP).
Definition
ChEBI: 4-[1-hydroxy-2-(4-phenylbutan-2-ylamino)propyl]phenol is an alkylbenzene.
Manufacturing Process
8 grams of the hydrobromide of 1-(p-benzoxyphenyl)-2-(α-methyl-γ-phenylpropylamino)-propanone-(1) were obtained by heating equivalent quantities of p-benzoxy-α-bromopropiophenone and 1-phenyl-3-amino-butane for an hour on the water bath in the absence of solvents. The product was purified by twice boiling with five times the quantity of acetic acid and filtration at 80°C, then shaken in contact with hydrogen with 0.8 gram of Raney nickel in 70 cc of pure methanol containing 0.96 gram (corresponding to 1 mol) of KOH. After 4 hours 2 mols of hydrogen had been taken up and the solution was filtered from the catalyst, evaporated in vacuo, and the residue triturated first with water to remove potassium bromide and then with methanol to remove potassium bromide. 3.7 grams (72% of the theoretical yield) of the compound specified, melting at 110° to 112°C, were obtained, as described in US Patent 2,661,373.
Therapeutic Function
Vasodilator
Nylidrin Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai TaoSu Biochemical Technology Co., Ltd. | 021-33632979 | info@tsbiochem.com | China | 8039 | 58 |
| ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 18149758185 | sales-cpd@caerulumpharma.com | China | 3493 | 58 |
| ChemeGen | 18818260767 | 2625930290@qq.com | China | 6966 | 58 |
| Shaanxi DIDU pharmaceutical and Chemical Co., Ltd | 029-029-029-81148696 18161915376 | 1027@dideu.com | China | 9989 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11963 | 58 |
| SHANGHAI KEAN TECHNOLOGY CO., LTD. | +8613817748580 | cooperation@kean-chem.com | China | 40048 | 58 |
| Jilin Chinese Academy of Sciences-yanshen Technology | 18143011203 | info@chemextension.com | China | 42052 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +86-18621343501 | product@acmec-e.com | China | 33301 | 58 |
| Shaanxi Didu New Materials Co. Ltd | +86-86-17392712779 +86-13289823923 | 1090@dideu.com | China | 8651 | 58 |
